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Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing

Journal of pharmaceutical sciences, 2020-12, Vol.109 (12), p.3574-3578

2020

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Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics

Therapeutic drug monitoring, 2020-02, Vol.42 (1), p.83-92

2020

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Personalizing Polymyxin B Dosing Using an Adaptive Feedback Control Algorithm

Antimicrobial agents and chemotherapy, 2018-07, Vol.62 (7)

2018

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Multi-scale model of drug induced adaptive resistance of Gram-negative bacteria to polymyxin B

PloS one, 2017-03, Vol.12 (3), p.e0171834-e0171834

2017

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Pharmacokinetic Considerations for Optimizing Inhaled Spray-Dried Pyrazinoic Acid Formulations

Molecular pharmaceutics, 2023-09, Vol.20 (9), p.4491-4504

2023

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Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations

Pathogens (Basel), 2022-11, Vol.11 (12), p.1420

2022

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Bifunctional antibiotic hybrids: A review of clinical candidates

Frontiers in pharmacology, 2023-06, Vol.14, p.1158152-1158152

2023

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Triple combination antibiotic therapy for carbapenemase-producing Klebsiella pneumoniae: a systematic review

Annals of clinical microbiology and antimicrobials, 2017-11, Vol.16 (1), p.76-76, Article 76

2017

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Comparative Proteomics of Outer Membrane Vesicles from Polymyxin-Susceptible and Extremely Drug-Resistant Klebsiella pneumoniae

mSphere, 2023-02, Vol.8 (1), p.e0053722-e0053722

2023

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Insights Into Patient Variability During Ivacaftor-Lumacaftor Therapy in Cystic Fibrosis

Frontiers in pharmacology, 2021-08, Vol.12, p.577263

2021

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Mechanisms Underlying Synergistic Killing of Polymyxin B in Combination with Cannabidiol against Acinetobacter baumannii : A Metabolomic Study

Pharmaceutics, 2022-04, Vol.14 (4), p.786

2022

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A mechanism‐based pharmacokinetic model of remdesivir leveraging interspecies scaling to simulate COVID‐19 treatment in humans

CPT: pharmacometrics and systems pharmacology, 2021-02, Vol.10 (2), p.89-99

2021

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Unique mechanistic insights into pathways associated with the synergistic activity of polymyxin B and caspofungin against multidrug-resistant Klebsiella pneumoniae

Computational and structural biotechnology journal, 2022-01, Vol.20, p.1077-1087

2022

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Assessing the predictive performance of population pharmacokinetic models for intravenous polymyxin B in critically ill patients

CPT: pharmacometrics and systems pharmacology, 2021-12, Vol.10 (12), p.1525-1537

2021

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Proof‐of‐concept for incorporating mechanistic insights from multi‐omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae

CPT: pharmacometrics and systems pharmacology, 2023-03, Vol.12 (3), p.387-400

2023

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Model-based learn and confirm: designing effective treatment regimens against multidrug resistant Gram-negative pathogens

International journal of antimicrobial agents, 2024-04, Vol.63 (4), p.107100-107100, Article 107100

2024

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New Dosing Strategies for an Old Antibiotic: Pharmacodynamics of Front-Loaded Regimens of Colistin at Simulated Pharmacokinetics in Patients with Kidney or Liver Disease

Antimicrobial Agents and Chemotherapy, 2014-03, Vol.58 (3), p.1381-1388

2014

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Moving From Point‐Based Analysis to Systems‐Based Modeling: Integration of Knowledge to Address Antimicrobial Resistance Against MDR Bacteria

Clinical pharmacology and therapeutics, 2021-11, Vol.110 (5), p.1196-1206

2021

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Antibiotic pharmacokinetic/pharmacodynamic modelling: MIC, pharmacodynamic indices and beyond

International journal of antimicrobial agents, 2021-08, Vol.58 (2), p.106368, Article 106368

2021

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Untargeted metabolomics to evaluate polymyxin B toxicodynamics following direct intracerebroventricular administration into the rat brain

Computational and structural biotechnology journal, 2022-01, Vol.20, p.6067-6077

2022

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High-level nitrofurantoin resistance in a clinical isolate of Klebsiella pneumoniae: a comparative genomics and metabolomics analysis

mSystems, 2024-01, Vol.9 (1), p.e0097223-e0097223

2024

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A systematic review and meta-analysis of treatment outcomes following antibiotic therapy among patients with carbapenem-resistant Klebsiella pneumoniae infections

International journal of antimicrobial agents, 2020-01, Vol.55 (1), p.105833-105833, Article 105833

2020

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Population Pharmacodynamic Modeling of Epoetin Alfa in End‐Stage Renal Disease Patients Receiving Maintenance Treatment Using Bayesian Approach

CPT: pharmacometrics and systems pharmacology, 2020-10, Vol.9 (10), p.596-605

2020

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Use of pharmacokinetic/pharmacodynamic approaches for dose optimization: a case study of plazomicin

Current opinion in microbiology, 2022-12, Vol.70, p.102204, Article 102204

2022

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Crossing the Chasm: How to Approach Translational Pharmacokinetic-Pharmacodynamic Modeling of Phage Dosing

Clinical pharmacology and therapeutics, 2024-09

2024

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Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing

Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics

Personalizing Polymyxin B Dosing Using an Adaptive Feedback Control Algorithm

Multi-scale model of drug induced adaptive resistance of Gram-negative bacteria to polymyxin B

Pharmacokinetic Considerations for Optimizing Inhaled Spray-Dried Pyrazinoic Acid Formulations

Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations

Bifunctional antibiotic hybrids: A review of clinical candidates

Triple combination antibiotic therapy for carbapenemase-producing Klebsiella pneumoniae: a systematic review

Comparative Proteomics of Outer Membrane Vesicles from Polymyxin-Susceptible and Extremely Drug-Resistant Klebsiella pneumoniae

Insights Into Patient Variability During Ivacaftor-Lumacaftor Therapy in Cystic Fibrosis

Mechanisms Underlying Synergistic Killing of Polymyxin B in Combination with Cannabidiol against Acinetobacter baumannii : A Metabolomic Study

A mechanism‐based pharmacokinetic model of remdesivir leveraging interspecies scaling to simulate COVID‐19 treatment in humans

Unique mechanistic insights into pathways associated with the synergistic activity of polymyxin B and caspofungin against multidrug-resistant Klebsiella pneumoniae

Assessing the predictive performance of population pharmacokinetic models for intravenous polymyxin B in critically ill patients

Proof‐of‐concept for incorporating mechanistic insights from multi‐omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae

Model-based learn and confirm: designing effective treatment regimens against multidrug resistant Gram-negative pathogens

New Dosing Strategies for an Old Antibiotic: Pharmacodynamics of Front-Loaded Regimens of Colistin at Simulated Pharmacokinetics in Patients with Kidney or Liver Disease

Moving From Point‐Based Analysis to Systems‐Based Modeling: Integration of Knowledge to Address Antimicrobial Resistance Against MDR Bacteria

Antibiotic pharmacokinetic/pharmacodynamic modelling: MIC, pharmacodynamic indices and beyond

Untargeted metabolomics to evaluate polymyxin B toxicodynamics following direct intracerebroventricular administration into the rat brain

High-level nitrofurantoin resistance in a clinical isolate of Klebsiella pneumoniae: a comparative genomics and metabolomics analysis

A systematic review and meta-analysis of treatment outcomes following antibiotic therapy among patients with carbapenem-resistant Klebsiella pneumoniae infections

Population Pharmacodynamic Modeling of Epoetin Alfa in End‐Stage Renal Disease Patients Receiving Maintenance Treatment Using Bayesian Approach

Use of pharmacokinetic/pharmacodynamic approaches for dose optimization: a case study of plazomicin

Crossing the Chasm: How to Approach Translational Pharmacokinetic-Pharmacodynamic Modeling of Phage Dosing

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