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Multi-scale model of drug induced adaptive resistance of Gram-negative bacteria to polymyxin B

PloS one, 2017-03, Vol.12 (3), p.e0171834-e0171834

2017

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Model-based learn and confirm: designing effective treatment regimens against multidrug resistant Gram-negative pathogens

International journal of antimicrobial agents, 2024-04, Vol.63 (4), p.107100-107100, Article 107100

2024

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Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing

Journal of pharmaceutical sciences, 2020-12, Vol.109 (12), p.3574-3578

2020

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Moving From Point‐Based Analysis to Systems‐Based Modeling: Integration of Knowledge to Address Antimicrobial Resistance Against MDR Bacteria

Clinical pharmacology and therapeutics, 2021-11, Vol.110 (5), p.1196-1206

2021

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Antibiotic pharmacokinetic/pharmacodynamic modelling: MIC, pharmacodynamic indices and beyond

International journal of antimicrobial agents, 2021-08, Vol.58 (2), p.106368, Article 106368

2021

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Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics

Therapeutic drug monitoring, 2020-02, Vol.42 (1), p.83-92

2020

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Personalizing Polymyxin B Dosing Using an Adaptive Feedback Control Algorithm

Antimicrobial agents and chemotherapy, 2018-07, Vol.62 (7)

2018

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A systematic review and meta-analysis of treatment outcomes following antibiotic therapy among patients with carbapenem-resistant Klebsiella pneumoniae infections

International journal of antimicrobial agents, 2020-01, Vol.55 (1), p.105833-105833, Article 105833

2020

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Use of pharmacokinetic/pharmacodynamic approaches for dose optimization: a case study of plazomicin

Current opinion in microbiology, 2022-12, Vol.70, p.102204, Article 102204

2022

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Crossing the Chasm: How to Approach Translational Pharmacokinetic-Pharmacodynamic Modeling of Phage Dosing

Clinical pharmacology and therapeutics, 2024-09

2024

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Pharmacokinetic Considerations for Optimizing Inhaled Spray-Dried Pyrazinoic Acid Formulations

Molecular pharmaceutics, 2023-09, Vol.20 (9), p.4491-4504

2023

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The development and validation of a simple liquid chromatography–tandem mass spectrometry method for polymyxin B1 and B2 quantification in different matrices

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017-10, Vol.1065-1066, p.112-118

2017

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Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations

Pathogens (Basel), 2022-11, Vol.11 (12), p.1420

2022

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Knowledge dissemination and central indexing of resources in pharmacometrics: an ISOP education working group initiative

Journal of pharmacokinetics and pharmacodynamics, 2022-08, Vol.49 (4), p.397-400

2022

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Reapproaching Old Treatments: Considerations for PK/PD Studies on Phage Therapy for Bacterial Respiratory Infections

Clinical pharmacology and therapeutics, 2021-06, Vol.109 (6), p.1443-1456

2021

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Value of pneumococcal vaccination in controlling the development of antimicrobial resistance (AMR): Case study using DREAMR in Ethiopia

Vaccine, 2021-10, Vol.39 (45), p.6700-6711

2021

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Pharmacokinetics/pharmacodynamics of phage therapy: a major hurdle to clinical translation

Clinical microbiology and infection, 2023-06, Vol.29 (6), p.702-709

2023

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Bifunctional antibiotic hybrids: A review of clinical candidates

Frontiers in pharmacology, 2023-06, Vol.14, p.1158152-1158152

2023

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Impact of Antibiotic Resistance on Treatment of Pneumococcal Disease in Ethiopia: An Agent-Based Modeling Simulation

The American journal of tropical medicine and hygiene, 2019-01, Vol.101 (5), p.1042-1053

2019

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Role of islatravir in HIV treatment and prevention: an update

Current opinion in HIV & AIDS, 2022-07, Vol.17 (4), p.240-246

2022

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Evaluation of Activity and Emergence of Resistance of Polymyxin B and ZTI-01 (Fosfomycin for Injection) against KPC-Producing Klebsiella pneumoniae

Antimicrobial agents and chemotherapy, 2018-02, Vol.62 (2)

2018

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The Complex Roadmap to Infectious Disease Innovation: The Intersection of Bugs, Drugs, and Special Populations

Clinical pharmacology and therapeutics, 2021-04, Vol.109 (4), p.793-796

2021

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Evaluation Strategies for Triple‐Drug Combinations against Carbapenemase‐Producing Klebsiella Pneumoniae in an In Vitro Hollow‐Fiber Infection Model

Clinical pharmacology and therapeutics, 2021-04, Vol.109 (4), p.1074-1080

2021

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Polymyxins for the treatment of lower respiratory tract infections: lessons learned from the integration of clinical pharmacokinetic studies and clinical outcomes

International journal of antimicrobial agents, 2021-06, Vol.57 (6), p.106328, Article 106328

2021

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Polymyxin B in combination with meropenem against carbapenemase-producing Klebsiella pneumoniae : pharmacodynamics and morphological changes

International journal of antimicrobial agents, 2017-02, Vol.49 (2), p.224-232

2017

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Multi-scale model of drug induced adaptive resistance of Gram-negative bacteria to polymyxin B

Model-based learn and confirm: designing effective treatment regimens against multidrug resistant Gram-negative pathogens

Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing

Moving From Point‐Based Analysis to Systems‐Based Modeling: Integration of Knowledge to Address Antimicrobial Resistance Against MDR Bacteria

Antibiotic pharmacokinetic/pharmacodynamic modelling: MIC, pharmacodynamic indices and beyond

Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics

Personalizing Polymyxin B Dosing Using an Adaptive Feedback Control Algorithm

A systematic review and meta-analysis of treatment outcomes following antibiotic therapy among patients with carbapenem-resistant Klebsiella pneumoniae infections

Use of pharmacokinetic/pharmacodynamic approaches for dose optimization: a case study of plazomicin

Crossing the Chasm: How to Approach Translational Pharmacokinetic-Pharmacodynamic Modeling of Phage Dosing

Pharmacokinetic Considerations for Optimizing Inhaled Spray-Dried Pyrazinoic Acid Formulations

The development and validation of a simple liquid chromatography–tandem mass spectrometry method for polymyxin B1 and B2 quantification in different matrices

Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations

Knowledge dissemination and central indexing of resources in pharmacometrics: an ISOP education working group initiative

Reapproaching Old Treatments: Considerations for PK/PD Studies on Phage Therapy for Bacterial Respiratory Infections

Value of pneumococcal vaccination in controlling the development of antimicrobial resistance (AMR): Case study using DREAMR in Ethiopia

Pharmacokinetics/pharmacodynamics of phage therapy: a major hurdle to clinical translation

Bifunctional antibiotic hybrids: A review of clinical candidates

Impact of Antibiotic Resistance on Treatment of Pneumococcal Disease in Ethiopia: An Agent-Based Modeling Simulation

Role of islatravir in HIV treatment and prevention: an update

Evaluation of Activity and Emergence of Resistance of Polymyxin B and ZTI-01 (Fosfomycin for Injection) against KPC-Producing Klebsiella pneumoniae

The Complex Roadmap to Infectious Disease Innovation: The Intersection of Bugs, Drugs, and Special Populations

Evaluation Strategies for Triple‐Drug Combinations against Carbapenemase‐Producing Klebsiella Pneumoniae in an In Vitro Hollow‐Fiber Infection Model

Polymyxins for the treatment of lower respiratory tract infections: lessons learned from the integration of clinical pharmacokinetic studies and clinical outcomes

Polymyxin B in combination with meropenem against carbapenemase-producing Klebsiella pneumoniae : pharmacodynamics and morphological changes

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