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Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond

Trends in endocrinology and metabolism, 2018-08, Vol.29 (8), p.560-570

2018

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GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

Nature medicine, 2017-10, Vol.23 (10), p.1150-1157

2017

Volltextzugriff (PDF)

Regulation of Fasted Blood Glucose by Resistin

Science (American Association for the Advancement of Science), 2004-02, Vol.303 (5661), p.1195-1198

2004

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Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia

Diabetes (New York, N.Y.), 2004-08, Vol.53 (8), p.1937-1941

2004

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HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

Nature (London), 2008-02, Vol.451 (7181), p.1008-1012

2008

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Peroxisome proliferator-activated receptor γ in diabetes and metabolism

Trends in pharmacological sciences (Regular ed.), 2004-06, Vol.25 (6), p.331-336

2004

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Estrogen-related Receptor γ Is a Key Regulator of Muscle Mitochondrial Activity and Oxidative Capacity

The Journal of biological chemistry, 2010-07, Vol.285 (29), p.22619-22629

2010

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A Long-Acting PYY 3-36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates

Cell metabolism, 2019-04, Vol.29 (4), p.837

2019

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A Long-Acting PYY3–36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates

Cell metabolism, 2019-04, Vol.29 (4), p.837-843.e5

2019

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Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake

Journal of applied physiology (1985), 2008-05, Vol.104 (5), p.1304-1312

2008

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Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists

European journal of medicinal chemistry, 2022-06, Vol.236, p.114330-114330, Article 114330

2022

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Transcriptional control of adipogenesis

Annual review of nutrition, 2000-01, Vol.20, p.535-559

2000

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Estrogen-related receptor α is essential for the expression of antioxidant protection genes and mitochondrial function

Biochemical and biophysical research communications, 2007-05, Vol.357 (1), p.231-236

2007

Volltextzugriff (PDF)

Interdomain communication regulating ligand binding by PPAR-γ

Nature (London), 1998-11, Vol.396 (6709), p.377-380

1998

Volltextzugriff (PDF)

Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival

The Journal of biological chemistry, 2002-08, Vol.277 (35), p.31781-31788

2002

Volltextzugriff (PDF)

Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H2 synthases by ibuprofen, naproxen, and indomethacin

Biochemical pharmacology, 2001-12, Vol.62 (12), p.1587-1595

2001

Volltextzugriff (PDF)

A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response

The Journal of clinical investigation, 1999-08, Vol.104 (4), p.383-389

1999

Volltextzugriff (PDF)

Genetic Modulation of PPARγ Phosphorylation Regulates Insulin Sensitivity

Developmental cell, 2003-10, Vol.5 (4), p.657-663

2003

Volltextzugriff (PDF)

Growth Differentiation Factor-15 (GDF-15) Inhibits Gastric Emptying in Rodents as Part of Its Anorectic Mechanism of Action

Diabetes (New York, N.Y.), 2018-07, Vol.67 (Supplement_1)

2018

Volltextzugriff (PDF)

Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H2 synthases by ibuprofen, naproxen, and indomethacin11Abbreviations: AA, arachidonic acid; ACO, acyl-CoA oxidase; COX; cyclooxygenase; NSAIDs, nonsteroidal anti-inflammatory drugs; PGHS, prostaglandin endoperoxide H synthase; PPP, platelet-poor plasma; PRP, platelet-rich plasma; PPAR, peroxisome proliferator-activated receptor; PPRE, peroxisome proliferator response element; and CoA coenzyme A

Biochemical pharmacology, 2001-12, Vol.62 (12), p.1587-1595

2001

Volltextzugriff (PDF)

Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H 2 synthases by ibuprofen, naproxen, and indomethacin

Biochemical pharmacology, 2001-12, Vol.62 (12), p.1587-1595

2001

Volltextzugriff (PDF)

Muscle-specific expression of PPAR^g coactivator-1^a improves exercise performance and increases peak oxygen uptake

Journal of applied physiology (1985), 2008-05, Vol.104 (5), p.1304-1312

2008

Volltextzugriff (PDF)

Muscle-specific expression of PPAR{gamma} coactivator-1{alpha} improves exercise performance and increases peak oxygen uptake

Journal of applied physiology (1985), 2008-05, Vol.104 (5), p.1304

2008

Volltextzugriff (PDF)

Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake

Journal of applied physiology (1985), 2008-05, Vol.104 (5), p.1304-1312

2008

Volltextzugriff (PDF)

Estrogen-related receptor {alpha} is essential for the expression of antioxidant protection genes and mitochondrial function

Biochemical and biophysical research communications, 2007-05, Vol.357 (1)

2007

Volltextzugriff (PDF)

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Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

Regulation of Fasted Blood Glucose by Resistin

Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

Peroxisome proliferator-activated receptor γ in diabetes and metabolism

Estrogen-related Receptor γ Is a Key Regulator of Muscle Mitochondrial Activity and Oxidative Capacity

A Long-Acting PYY 3-36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates

A Long-Acting PYY3–36 Analog Mediates Robust Anorectic Efficacy with Minimal Emesis in Nonhuman Primates

Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake

Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists

Transcriptional control of adipogenesis

Estrogen-related receptor α is essential for the expression of antioxidant protection genes and mitochondrial function

Interdomain communication regulating ligand binding by PPAR-γ

Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival

Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H2 synthases by ibuprofen, naproxen, and indomethacin

A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response

Genetic Modulation of PPARγ Phosphorylation Regulates Insulin Sensitivity

Growth Differentiation Factor-15 (GDF-15) Inhibits Gastric Emptying in Rodents as Part of Its Anorectic Mechanism of Action

Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H 2 synthases by ibuprofen, naproxen, and indomethacin

Muscle-specific expression of PPAR^g coactivator-1^a improves exercise performance and increases peak oxygen uptake

Muscle-specific expression of PPAR{gamma} coactivator-1{alpha} improves exercise performance and increases peak oxygen uptake

Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake

Estrogen-related receptor {alpha} is essential for the expression of antioxidant protection genes and mitochondrial function

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