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Rapid decrease of wild-type hepatitis C virus on telaprevir treatment

Antiviral therapy, 2009-01, Vol.14 (4), p.591-595

2009

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Open-label phase 1b pilot study to assess the antiviral efficacy of simvastatin combined with sertraline in chronic hepatitis C patients

Antiviral therapy, 2011-01, Vol.16 (8), p.1341-1346

2011

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ICE/Caspase-1 inhibitors as novel anti-inflammatory drugs

Expert opinion on investigational drugs, 2001-07, Vol.10 (7), p.1207-1209

2001

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Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity

Journal of medicinal chemistry, 2000-06, Vol.43 (12), p.2371-2381

2000

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Spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives are mixed AMPA and NMDA glycine-site antagonists active in vivo

Bioorganic & medicinal chemistry letters, 1999-10, Vol.9 (20), p.2921-2926

1999

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Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2- a]indeno[1,2- e]pyrazin-8- and -9-carboxylic (acetic) acid AMPA antagonists

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (24), p.2749-2754

2000

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Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (2), p.127-132

2001

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4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity

Bioorganic & medicinal chemistry letters, 2000-05, Vol.10 (10), p.1133

2000

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Synthesis of anticonvulsive AMPA antagonists: 4-Oxo-10-substituted-imidazo[1,2- a]indeno[1,2- e]pyrazin-2-carboxylic acid derivatives

Bioorganic & medicinal chemistry letters, 2001-05, Vol.11 (9), p.1205-1210

2001

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Structure-activity relationships in a series of 3-sulfonylamino-2-(1 H)-quinolones, as new AMPA/Kainate and glycine antagonists

Bioorganic & medicinal chemistry, 1995-02, Vol.3 (2), p.129-141

1995

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8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones : Highly in vivo potent and selective AMPA receptor antagonists

Bioorganic & medicinal chemistry, 2000-08, Vol.8 (8), p.2211-2217

2000

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Actions of gamma-aminobutyric acid on rat supraoptic nucleus neurosecretory neurones in vitro

The Journal of physiology, 1987-06, Vol.387 (1), p.629-647

1987

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Competitive inhibition by NBQX of kainate/AMPA receptor currents and excitatory synaptic potentials: importance of 6-nitro substitution

European journal of pharmacology, 1992-05, Vol.215 (2), p.237-244

1992

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Calcium-dependent potassium conductance in rat supraoptic nucleus neurosecretory neurons

Journal of neurophysiology, 1985-12, Vol.54 (6), p.1375-1382

1985

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Quinoxaline derivatives: structure-activity relationships and physiological implications of inhibition of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated currents and synaptic potentials

Molecular pharmacology, 1992-02, Vol.41 (2), p.337-345

1992

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Allosteric potentiation by diazoxide of AMPA receptor currents and synaptic potentials

European journal of pharmacology, 1993-11, Vol.247 (3), p.257-265

1993

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Alpha 1-adrenergic receptor activation releases vasopressin and oxytocin from perfused rat hypothalamic explants

Neuroscience letters, 1986-04, Vol.65 (2), p.219-223

1986

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Synthesis and pharmacological properties of 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, a new competitive AMPA/KA receptor antagonist

Drug development research, 1999-11, Vol.48 (3), p.121-129

1999

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Characterization of spontaneous and evoked inhibitory postsynaptic potentials in rat supraoptic neurosecretory neurons in vitro

Journal of neurophysiology, 1986-12, Vol.56 (6), p.1703-1717

1986

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Serial reconstruction of lucifer yellow-labeled supraoptic nucleus neurons in perfused rat hypothalamic explants

Neuroscience, 1986-02, Vol.17 (2), p.453-467

1986

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Cardiovascular input to hypothalamic neurosecretory neurons

Brain research bulletin, 1988-06, Vol.20 (6), p.771-777

1988

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Synthesis and sar of 2h-1,2,4-benzothiadiazine-1,1-dioxide-3- carboxylic acid derivatives as novel potent glycine antagonists of the nmda receptor-channel complex

Bioorganic & medicinal chemistry letters, 1994, Vol.4 (23), p.2735-2740

1994

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Excitatory amino acid receptors: NMDA modulatory sites, kainate cloned and a new role in AIDS

Trends in pharmacological sciences (Regular ed.), 1990, Vol.11 (1), p.1-3

1990

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α-Adrenergic activation of rat hypothalamic supraoptic neurons maintained in vitro

Brain research, 1984-07, Vol.307 (1), p.374-378

1984

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Properties of the kainate channel in rat brain mRNA injected Xenopus oocytes: ionic selectivity and blockage

Molecular and cellular biochemistry, 1989-07, Vol.80 (1-2), p.121-132

1989

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Rapid decrease of wild-type hepatitis C virus on telaprevir treatment

Open-label phase 1b pilot study to assess the antiviral efficacy of simvastatin combined with sertraline in chronic hepatitis C patients

ICE/Caspase-1 inhibitors as novel anti-inflammatory drugs

Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity

Spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives are mixed AMPA and NMDA glycine-site antagonists active in vivo

Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2- a]indeno[1,2- e]pyrazin-8- and -9-carboxylic (acetic) acid AMPA antagonists

Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action

4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity

Synthesis of anticonvulsive AMPA antagonists: 4-Oxo-10-substituted-imidazo[1,2- a]indeno[1,2- e]pyrazin-2-carboxylic acid derivatives

Structure-activity relationships in a series of 3-sulfonylamino-2-(1 H)-quinolones, as new AMPA/Kainate and glycine antagonists

8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones : Highly in vivo potent and selective AMPA receptor antagonists

Actions of gamma-aminobutyric acid on rat supraoptic nucleus neurosecretory neurones in vitro

Competitive inhibition by NBQX of kainate/AMPA receptor currents and excitatory synaptic potentials: importance of 6-nitro substitution

Calcium-dependent potassium conductance in rat supraoptic nucleus neurosecretory neurons

Quinoxaline derivatives: structure-activity relationships and physiological implications of inhibition of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated currents and synaptic potentials

Allosteric potentiation by diazoxide of AMPA receptor currents and synaptic potentials

Alpha 1-adrenergic receptor activation releases vasopressin and oxytocin from perfused rat hypothalamic explants

Synthesis and pharmacological properties of 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, a new competitive AMPA/KA receptor antagonist

Characterization of spontaneous and evoked inhibitory postsynaptic potentials in rat supraoptic neurosecretory neurons in vitro

Serial reconstruction of lucifer yellow-labeled supraoptic nucleus neurons in perfused rat hypothalamic explants

Cardiovascular input to hypothalamic neurosecretory neurons

Synthesis and sar of 2h-1,2,4-benzothiadiazine-1,1-dioxide-3- carboxylic acid derivatives as novel potent glycine antagonists of the nmda receptor-channel complex

Excitatory amino acid receptors: NMDA modulatory sites, kainate cloned and a new role in AIDS

α-Adrenergic activation of rat hypothalamic supraoptic neurons maintained in vitro

Properties of the kainate channel in rat brain mRNA injected Xenopus oocytes: ionic selectivity and blockage

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