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Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist

The Journal of pharmacology and experimental therapeutics, 1994-07, Vol.270 (1), p.228

1994

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Fragmentation of Bosentan ® (Ro 47-0203) in ionspray mass spectrometry after collision-induced dissociation at low energy: a case of radical fragmentation of an even-electron ion

Journal of mass spectrometry., 1996-01, Vol.31 (1), p.69-76

1996

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Novel Benzo[1,4]diazepin-2-one Derivatives as Endothelin Receptor Antagonists

Journal of medicinal chemistry, 2004-05, Vol.47 (11), p.2776-2795

2004

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Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use

The Journal of pharmacology and experimental therapeutics, 1999-08, Vol.290 (2), p.840

1999

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Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Nature (London), 1993-10, Vol.365 (6448), p.759-761

1993

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Ro 61-1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1110

1997

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The dithiane Ro 44-5912 enhances vinblastine sensitivity of drug resistant and parental KB lines in vivo

European journal of cancer (1990), 1995-12, Vol.31 (13), p.2354-2361

1995

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SULFONAMIDE-BASED ANTAGONISTS OF THE ENDOTHELIN RECEPTORS

European journal of medicinal chemistry, 1995, Vol.30, p.385s-389s

1995

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A new Ca++ antagonist, Ro 11-1781, and its metabolites. Synthesis and physicochemical properties

Arzneimittel-Forschung, 1978, Vol.28 (11), p.2048

Ramuz, H

1978

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Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan

Bioorganic & medicinal chemistry letters, 1997-09, Vol.7 (17), p.2223-2228

1997

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Asymmetric Hydrogenation vs. Resolution in the Synthesis of POSICOR®, a New Type of Calcium Antagonist

Chimia, 1997-06, Vol.51 (6), p.303

1997

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Antihypertensive (2-aminoethyl)thiourea derivatives. 2

Journal of medicinal chemistry, 1980-12, Vol.23 (12), p.1438-1439

1980

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Novel dithiane analogues of tiapamil with high activity to overcome multidrug resistance in vitro

Biochemical pharmacology, 1995-07, Vol.50 (2), p.187-196

1995

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The Discovery of Nonpeptide Endothelin Receptor Antagonists. Progression towards Bosentan

Chimia, 1996-11, Vol.50 (11), p.519

1996

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Human multi‐drug‐resistant cancer cells exhibit a high degree of selectivity for stereoisomers of verapamil and quinidine

International journal of cancer, 1990-07, Vol.46 (1), p.113-117

1990

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Tiapamil, Ro 11-1781, a Ca++ Antagonist

Cardiology, 1982, Vol.69 (1), p.26-30

Ramuz, H.

1982

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Tiapamil, Ro 11-1781, a Ca++ antagonist. An improved synthesis, physiochemical properties, preparation of a deuterated derivative

Cardiology, 1982, Vol.69 Suppl, p.26

Ramuz, H

1982

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In vitro characterisation of Ro 46‐8443, the first non‐peptide antagonist selective for the endothelin ETB receptor

FEBS letters, 1996-03, Vol.383 (1-2), p.37-41

1996

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Separable binding sites for the natural agonist endothelin-1 and the non-peptide antagonist bosentan on human endothelin-A receptors

European journal of biochemistry, 1995-07, Vol.231 (1), p.266-270

1995

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Human multi-drug-resistant cancer cells exhibit a high degree of selectivity for stereosomers of verapamil and quinidine

International journal of cancer, 1990, Vol.46 (1), p.113-117

1990

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Synthesis and absolute configuration of the enantiomers of verapamil (author's transl)

Helvetica chimica acta, 1975-11, Vol.58 (7), p.2050-2060

Ramuz, H

1975

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Ro 11–2933, a potential drug in the treatment of cancer and malaria: synthesis and physicochemical properties; potential metabolites

European journal of medicinal chemistry, 1989-09, Vol.24 (5), p.493-496

1989

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ChemInform Abstract: A NEW CALCIUM(2+) ANTAGONIST, RO 11‐1781, AND ITS METABOLITES. SYNTHESIS AND PHYSICOCHEMICAL PROPERTIES

Chemischer Informationsdienst, 1979-03, Vol.10 (11)

RAMUZ, H.

1979

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697. Alkaloid biosynthesis. Part IV. 1-Benzylisoquinolines as precursors of thebaine, codeine, and morphine

Journal of the Chemical Society, 1964, p.3600

1964

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Simultaneous determination of chloroquine and selected calcium(II) channel blockers by high-performance liquid chromatography

Analytica chimica acta, 1990, Vol.228 (1), p.155-157

1990

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Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist

Fragmentation of Bosentan ® (Ro 47-0203) in ionspray mass spectrometry after collision-induced dissociation at low energy: a case of radical fragmentation of an even-electron ion

Novel Benzo[1,4]diazepin-2-one Derivatives as Endothelin Receptor Antagonists

Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Ro 61-1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm

The dithiane Ro 44-5912 enhances vinblastine sensitivity of drug resistant and parental KB lines in vivo

SULFONAMIDE-BASED ANTAGONISTS OF THE ENDOTHELIN RECEPTORS

A new Ca++ antagonist, Ro 11-1781, and its metabolites. Synthesis and physicochemical properties

Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan

Asymmetric Hydrogenation vs. Resolution in the Synthesis of POSICOR®, a New Type of Calcium Antagonist

Antihypertensive (2-aminoethyl)thiourea derivatives. 2

Novel dithiane analogues of tiapamil with high activity to overcome multidrug resistance in vitro

The Discovery of Nonpeptide Endothelin Receptor Antagonists. Progression towards Bosentan

Human multi‐drug‐resistant cancer cells exhibit a high degree of selectivity for stereoisomers of verapamil and quinidine

Tiapamil, Ro 11-1781, a Ca++ Antagonist

Tiapamil, Ro 11-1781, a Ca++ antagonist. An improved synthesis, physiochemical properties, preparation of a deuterated derivative

In vitro characterisation of Ro 46‐8443, the first non‐peptide antagonist selective for the endothelin ETB receptor

Separable binding sites for the natural agonist endothelin-1 and the non-peptide antagonist bosentan on human endothelin-A receptors

Human multi-drug-resistant cancer cells exhibit a high degree of selectivity for stereosomers of verapamil and quinidine

Synthesis and absolute configuration of the enantiomers of verapamil (author's transl)

Ro 11–2933, a potential drug in the treatment of cancer and malaria: synthesis and physicochemical properties; potential metabolites

ChemInform Abstract: A NEW CALCIUM(2+) ANTAGONIST, RO 11‐1781, AND ITS METABOLITES. SYNTHESIS AND PHYSICOCHEMICAL PROPERTIES

697. Alkaloid biosynthesis. Part IV. 1-Benzylisoquinolines as precursors of thebaine, codeine, and morphine

Simultaneous determination of chloroquine and selected calcium(II) channel blockers by high-performance liquid chromatography

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