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Asymmetric Total Synthesis of an Important 3-(Hydroxymethyl)carbacephalosporin

Journal of organic chemistry, 1998-02, Vol.63 (4), p.1221-1225

1998

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Framework-Reactive Siderophore Analogs as Potential Cell-Selective Drugs. Design and Syntheses of Trimelamol-Based Iron Chelators

Journal of organic chemistry, 1996-06, Vol.61 (12), p.4120-4124

1996

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Peptidomimetics of the immunoglobulin supergene family — a review

Gene, 1993-12, Vol.137 (1), p.51-56

1993

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Peptidomimetic antagonists designed to inhibit the binding of CD4 to HIV GP120

Bioorganic & medicinal chemistry, 1994-09, Vol.2 (9), p.1007-1013

1994

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The synthesis of enantiomerically pure, highly functionalized heterocycles: the products of amino acid based acylnitroso hetero Diels-Alder reactions

Enantiomer, 1997, Vol.2 (5), p.367

1997

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ChemInform Abstract: Asymmetric Total Synthesis of an Important 3-(Hydroxymethyl)carbacephalosporin

ChemInform, 1998-06, Vol.29 (26), p.no-no

1998

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Organophosphate hydrolase interacts with Ton components and is targeted to the membrane only in the presence of the ExbB/ExbD complex

FEBS letters, 2019-03, Vol.593 (6), p.581-593

2019

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Discovery of Potent and Selective RSK Inhibitors as Biological Probes

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.6766-6783

2015

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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF

Cancer research (Chicago, Ill.), 2018-03, Vol.78 (6), p.1537-1548

2018

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TonB-Dependent Transporters in Sphingomonads: Unraveling Their Distribution and Function in Environmental Adaptation

Microorganisms (Basel), 2020-03, Vol.8 (3), p.359

2020

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Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3

Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8482-8514

2017

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Organophosphate hydrolase interacts with ferric-enterobactin and promotes iron uptake in association with TonB-dependent transport system

Biochemical journal, 2020-08, Vol.477 (15), p.2821-2840

2020

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Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator

Journal of medicinal chemistry, 2024-04, Vol.67 (7), p.5259-5271

2024

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The Organophosphate Degradation (opd) Island-borne Esterase-induced Metabolic Diversion in Escherichia coli and Its Influence on p-Nitrophenol Degradation

The Journal of biological chemistry, 2015-12, Vol.290 (50), p.29920-29930

2015

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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.2013-2027

2020

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Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma

ACS medicinal chemistry letters, 2015-09, Vol.6 (9), p.961-965

2015

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Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126930, Article 126930

2020

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Design and synthesis of potent RSK inhibitors

Bioorganic & medicinal chemistry letters, 2018-10, Vol.28 (19), p.3197-3201

2018

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Structural and Biological Basis of Small Molecule Inhibition of Escherichia coli LpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis

ACS infectious diseases, 2020-06, Vol.6 (6), p.1480-1489

2020

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Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors

Journal of medicinal chemistry, 2008-11, Vol.51 (22), p.7049-7052

2008

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Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.DDT01-04-DDT01-04

2018

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Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.330-330

2016

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Abstract 330: Development of a highly selective BCRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.330-330

2016

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Genome-Guided Insights Reveal Organophosphate-Degrading Brevundimonas diminuta as Sphingopyxis wildii and Define Its Versatile Metabolic Capabilities and Environmental Adaptations

Genome biology and evolution, 2017-01, Vol.9 (1), p.77-81

2017

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Asymmetric Total Synthesis of an Important 3-(Hydroxymethyl)carbacephalosporin

Framework-Reactive Siderophore Analogs as Potential Cell-Selective Drugs. Design and Syntheses of Trimelamol-Based Iron Chelators

Peptidomimetics of the immunoglobulin supergene family — a review

Peptidomimetic antagonists designed to inhibit the binding of CD4 to HIV GP120

The synthesis of enantiomerically pure, highly functionalized heterocycles: the products of amino acid based acylnitroso hetero Diels-Alder reactions

ChemInform Abstract: Asymmetric Total Synthesis of an Important 3-(Hydroxymethyl)carbacephalosporin

Organophosphate hydrolase interacts with Ton components and is targeted to the membrane only in the presence of the ExbB/ExbD complex

Discovery of Potent and Selective RSK Inhibitors as Biological Probes

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF

TonB-Dependent Transporters in Sphingomonads: Unraveling Their Distribution and Function in Environmental Adaptation

Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3

Organophosphate hydrolase interacts with ferric-enterobactin and promotes iron uptake in association with TonB-dependent transport system

Discovery of HC-7366: An Orally Bioavailable and Efficacious GCN2 Kinase Activator

The Organophosphate Degradation (opd) Island-borne Esterase-induced Metabolic Diversion in Escherichia coli and Its Influence on p-Nitrophenol Degradation

Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma

Discovery and optimization of novel pyridines as highly potent and selective glycogen synthase kinase 3 inhibitors

Design and synthesis of potent RSK inhibitors

Structural and Biological Basis of Small Molecule Inhibition of Escherichia coli LpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis

Inhibition of prenylated KRAS in a lipid environment

Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors

Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor

Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation

Abstract 330: Development of a highly selective BCRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation

Genome-Guided Insights Reveal Organophosphate-Degrading Brevundimonas diminuta as Sphingopyxis wildii and Define Its Versatile Metabolic Capabilities and Environmental Adaptations

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