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Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling

NPJ systems biology and applications, 2020-08, Vol.6 (1), p.28-28, Article 28

2020

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A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types

NPJ precision oncology, 2018-03, Vol.2 (1), p.7-7, Article 7

2018

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Development of a multi-biomarker disease activity test for rheumatoid arthritis

PloS one, 2013-04, Vol.8 (4), p.e60635-e60635

2013

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Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity

Arthritis care & research (2010), 2012-12, Vol.64 (12), p.1794-1803

2012

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Systems‐based digital twins to help characterize clinical dose–response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL

Clinical and translational science, 2023-07, Vol.16 (7), p.1134-1148

2023

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Digital twins elucidate critical role of Tscm in clinical persistence of TCR-engineered cell therapy

NPJ systems biology and applications, 2024-01, Vol.10 (1), p.11-12, Article 11

2024

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Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach

Journal of lipid research, 2016-01, Vol.57 (1), p.46-55

2016

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Diffusion and Convection in Collagen Gels: Implications for Transport in the Tumor Interstitium

Biophysical journal, 2002-09, Vol.83 (3), p.1650-1660

2002

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gQSPSim: A SimBiology‐Based GUI for Standardized QSP Model Development and Application

CPT: pharmacometrics and systems pharmacology, 2020-03, Vol.9 (3), p.165-176

2020

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A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule

Pharmaceutics, 2024-05, Vol.16 (5), p.660

2024

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A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma

Clinical and translational science, 2023-04, Vol.16 (4), p.694-703

2023

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Mechanistic Modeling of Soluble Aβ Dynamics and Target Engagement in the Brain by Anti-Aβ mAbs in Alzheimer’s Disease

Current Alzheimer research, 2020-01, Vol.17 (4), p.393-406

2020

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A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation

Immunity (Cambridge, Mass.), 2005-08, Vol.23 (2), p.115-126

2005

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Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making

Frontiers in pharmacology, 2022-04, Vol.13, p.860881

2022

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Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates

CPT: pharmacometrics and systems pharmacology, 2023-01, Vol.12 (1), p.62-73

2023

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Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3‐kinase inhibitors

CPT: pharmacometrics and systems pharmacology, 2022-05, Vol.11 (5), p.616-627

2022

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Integrated systems modeling of severe asthma: Exploration of IL‐33/ST2 antagonism

CPT: pharmacometrics and systems pharmacology, 2022-09, Vol.11 (9), p.1268-1277

2022

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A Flexible Approach for Context‐Dependent Assessment of Quantitative Systems Pharmacology Models

CPT: pharmacometrics and systems pharmacology, 2019-06, Vol.8 (6), p.340-343

2019

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Role of Tumor-Host Interactions in Interstitial Diffusion of Macromolecules: Cranial vs. Subcutaneous Tumors

Proceedings of the National Academy of Sciences - PNAS, 2001-04, Vol.98 (8), p.4628-4633

2001

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The convergence of pharmacometrics and quantitative systems pharmacology in pharmaceutical research and development

European journal of pharmaceutical sciences, 2023-03, Vol.182, p.106380, Article 106380

2023

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Erratum: Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model

NPJ systems biology and applications, 2017-09, Vol.3 (1), p.25-25

2017

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Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model

NPJ systems biology and applications, 2017-06, Vol.3 (1), p.14-14

2017

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Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model

NPJ systems biology and applications, 2017-06, Vol.3 (1), p.1-17, Article 14

2017

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Complex PK-PD of an engineered IL-15/IL-15Rα–Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics

European journal of pharmaceutical sciences, 2023-07, Vol.186, p.106450-106450, Article 106450

2023

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Differential Dynamics of CD4+ and CD8+ T-Lymphocyte Proliferation and Activation in Acute Simian Immunodeficiency Virus Infection

Journal of Virology, 2000-09, Vol.74 (18), p.8413-8424

2000

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Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling

A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types

Development of a multi-biomarker disease activity test for rheumatoid arthritis

Validation of a novel multibiomarker test to assess rheumatoid arthritis disease activity

Systems‐based digital twins to help characterize clinical dose–response and propose predictive biomarkers in a Phase I study of bispecific antibody, mosunetuzumab, in NHL

Digital twins elucidate critical role of Tscm in clinical persistence of TCR-engineered cell therapy

Evaluation of HDL-modulating interventions for cardiovascular risk reduction using a systems pharmacology approach

Diffusion and Convection in Collagen Gels: Implications for Transport in the Tumor Interstitium

gQSPSim: A SimBiology‐Based GUI for Standardized QSP Model Development and Application

A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule

A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma

Mechanistic Modeling of Soluble Aβ Dynamics and Target Engagement in the Brain by Anti-Aβ mAbs in Alzheimer’s Disease

A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation

Navigating Between Right, Wrong, and Relevant: The Use of Mathematical Modeling in Preclinical Decision Making

Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates

Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3‐kinase inhibitors

Integrated systems modeling of severe asthma: Exploration of IL‐33/ST2 antagonism

A Flexible Approach for Context‐Dependent Assessment of Quantitative Systems Pharmacology Models

Role of Tumor-Host Interactions in Interstitial Diffusion of Macromolecules: Cranial vs. Subcutaneous Tumors

The convergence of pharmacometrics and quantitative systems pharmacology in pharmaceutical research and development

Erratum: Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model

Clinical responses to ERK inhibition in BRAFV600E-mutant colorectal cancer predicted using a computational model

Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model

Complex PK-PD of an engineered IL-15/IL-15Rα–Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics

Differential Dynamics of CD4+ and CD8+ T-Lymphocyte Proliferation and Activation in Acute Simian Immunodeficiency Virus Infection

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