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Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae

Nature communications, 2021-09, Vol.12 (1), p.5400-5400, Article 5400

2021

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In Vitro and In Vivo Efficacy of β-Lactams against Replicating and Slowly Growing/Nonreplicating Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy, 2013-06, Vol.57 (6), p.2506-2510

2013

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Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy

Scientific reports, 2018-05, Vol.8 (1), p.7263-18, Article 7263

2018

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Assessment of Mycobacterium tuberculosis Pantothenate Kinase Vulnerability through Target Knockdown and Mechanistically Diverse Inhibitors

Antimicrobial agents and chemotherapy, 2014-06, Vol.58 (6), p.3312-3326

2014

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Identification of key amino acid residues in OqxB mediated efflux of fluoroquinolones using site-directed mutagenesis

Research in microbiology, 2023-05, Vol.174 (4), p.104039-104039, Article 104039

2023

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Biarylmethoxy Nicotinamides As Novel and Specific Inhibitors of Mycobacterium tuberculosis

ACS medicinal chemistry letters, 2014-05, Vol.5 (5), p.491-495

2014

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2-Amino-5-nitropyridinium trifluoroacetate

Acta crystallographica. Section E, Structure reports online, 2013-06, Vol.69 (6), p.o841-o842

2013

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Discovery of Pyrazolopyridones as a Novel Class of Noncovalent DprE1 Inhibitor with Potent Anti-Mycobacterial Activity

Journal of medicinal chemistry, 2014-06, Vol.57 (11), p.4761-4771

2014

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1,4-azaindole, a potential drug candidate for treatment of tuberculosis

Antimicrobial agents and chemotherapy, 2014-09, Vol.58 (9), p.5325-5331

2014

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Validated In Silico Model for Biofilm Formation in Escherichia coli

ACS synthetic biology, 2022-02, Vol.11 (2), p.713-731

2022

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Discovery of Imidazo[1,2‑a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1379-1399

2017

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Azaindoles: Noncovalent DprE1 Inhibitors from Scaffold Morphing Efforts, Kill Mycobacterium tuberculosis and Are Efficacious in Vivo

Journal of medicinal chemistry, 2013-12, Vol.56 (23), p.9701-9708

2013

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A kinetic platform for in silico modeling of the metabolic dynamics in Escherichia coli

Advances and applications in bioinformatics and chemistry, 2010, Vol.3, p.97-110

2010

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Simple and rapid method to determine antimycobacterial potency of compounds by using autoluminescent Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2014-10, Vol.58 (10), p.5801-5808

2014

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4‑Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity

Journal of medicinal chemistry, 2014-06, Vol.57 (12), p.5419-5434

2014

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Scaffold Morphing To Identify Novel DprE1 Inhibitors with Antimycobacterial Activity

ACS medicinal chemistry letters, 2019-10, Vol.10 (10), p.1480-1485

2019

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Diarylthiazole: An Antimycobacterial Scaffold Potentially Targeting PrrB-PrrA Two-Component System

Journal of medicinal chemistry, 2014-08, Vol.57 (15), p.6572-6582

2014

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Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series

Bioorganic & medicinal chemistry letters, 2013-09, Vol.23 (17), p.4996-5001

2013

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Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target

Tuberculosis (Edinburgh, Scotland), 2015-09, Vol.95 (5), p.589-598

2015

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Whole cell screen based identification of spiropiperidines with potent antitubercular properties

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3234-3245

2015

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Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria

ACS infectious diseases, 2021-11, Vol.7 (11), p.3009-3024

2021

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Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity

ChemMedChem, 2016-02, Vol.11 (3), p.331-339

2016

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In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment

Antimicrobial agents and chemotherapy, 2015-09, Vol.59 (9), p.5664-5674

2015

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UDP-N-acetylmuramic acid l-alanine ligase (MurC) inhibition in a tolC mutant Escherichia coli strain leads to cell death

Antimicrobial agents and chemotherapy, 2014-10, Vol.58 (10), p.6165-6171

2014

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Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae

In Vitro and In Vivo Efficacy of β-Lactams against Replicating and Slowly Growing/Nonreplicating Mycobacterium tuberculosis

Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy

Assessment of Mycobacterium tuberculosis Pantothenate Kinase Vulnerability through Target Knockdown and Mechanistically Diverse Inhibitors

Identification of key amino acid residues in OqxB mediated efflux of fluoroquinolones using site-directed mutagenesis

Biarylmethoxy Nicotinamides As Novel and Specific Inhibitors of Mycobacterium tuberculosis

2-Amino-5-nitropyridinium trifluoroacetate

Discovery of Pyrazolopyridones as a Novel Class of Noncovalent DprE1 Inhibitor with Potent Anti-Mycobacterial Activity

1,4-azaindole, a potential drug candidate for treatment of tuberculosis

Validated In Silico Model for Biofilm Formation in Escherichia coli

Discovery of Imidazo[1,2‑a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis

Azaindoles: Noncovalent DprE1 Inhibitors from Scaffold Morphing Efforts, Kill Mycobacterium tuberculosis and Are Efficacious in Vivo

A kinetic platform for in silico modeling of the metabolic dynamics in Escherichia coli

Simple and rapid method to determine antimycobacterial potency of compounds by using autoluminescent Mycobacterium tuberculosis

4‑Aminoquinolone Piperidine Amides: Noncovalent Inhibitors of DprE1 with Long Residence Time and Potent Antimycobacterial Activity

Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure–activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase

Scaffold Morphing To Identify Novel DprE1 Inhibitors with Antimycobacterial Activity

Diarylthiazole: An Antimycobacterial Scaffold Potentially Targeting PrrB-PrrA Two-Component System

Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series

Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target

Whole cell screen based identification of spiropiperidines with potent antitubercular properties

Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria

Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity

In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment

UDP-N-acetylmuramic acid l-alanine ligase (MurC) inhibition in a tolC mutant Escherichia coli strain leads to cell death

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