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Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives

Journal of medicinal chemistry, 1993-09, Vol.36 (19), p.2801-2809

1993

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Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative

Journal of medicinal chemistry, 1988-09, Vol.31 (9), p.1694-1697

1988

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Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives

Journal of medicinal chemistry, 1998-09, Vol.41 (19), p.3645-3654

1998

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Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents

Journal of medicinal chemistry, 1995-07, Vol.38 (14), p.2531-2540

1995

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Effects of SW 33377, SW 68210 and SW 71425 thioxanthones on in vitro colony formation of freshly explanted human tumor cells

Investigational new drugs, 1998-01, Vol.16 (3), p.221-225

1998

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PARVODICIN, A NOVEL GLYCOPEPTIDE FROM A NEW SPECIES, ACTINOMADURA PARVOSATA: DISCOVERY, TAXONOMY, ACTIVITY AND STRUCTURE ELUCIDATION

The Journal of Antibiotics, 1987/07/25, Vol.40(7), pp.970-990

1987

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AFFINITY OF CEFONICID, A LONG-ACTING CEPHALOSPORIN, FOR THE PENICILLIN-BINDING PROTEINS OF ESCHERICHIA COLI K-12

The Journal of Antibiotics, 1984, Vol.37(5), pp.572-576

1984

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Neurotensin receptor-mediated inhibition of pancreatic cancer cell growth by the neurotensin antagonist SR 48692

Anticancer research, 1999-01, Vol.19 (1A), p.213

1999

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Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)

Biochemical pharmacology, 1995-06, Vol.50 (1), p.111-122

1995

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The antitumor activity of novel pyrazoloquinoline derivatives

Bioorganic & medicinal chemistry letters, 1995-02, Vol.5 (4), p.405-410

1995

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Inhibition of platelet-derived growth factor-mediated signal transduction by transforming ras. Suppression of receptor autophosphorylation

The Journal of biological chemistry, 1991-03, Vol.266 (8), p.5348-5352

1991

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Anti-solid tumor efficacy and preparation of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl]methyl]methanesulfonamide (WIN 33377) and related derivatives

Bioorganic & medicinal chemistry letters, 1994-02, Vol.4 (4), p.609-614

1994

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Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events

The Journal of biological chemistry, 1991-07, Vol.266 (21), p.14055-14063

1991

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Cyclic variations of SR 233377 (WIN 33377) and effects on antitumor activity

Bioorganic & medicinal chemistry letters, 1996-06, Vol.6 (12), p.1345-1350

1996

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Anti-solid tumor efficacy and preparation of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9 H-thioxanthen-4-yl]methyl]methanesulfonamide (win 33377) and related derivatives

Bioorganic & medicinal chemistry letters, 1994, Vol.4 (4), p.609-614

1994

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Mechanism of action and antitumor activity of ( S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H-pyridol [1,2,3- de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)

Biochemical pharmacology, 1995-06, Vol.50 (1), p.111-122

1995

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Past and current asbestos exposure and future mesothelioma risks in Britain: The Inhaled Particles Study (TIPS)

International journal of epidemiology, 2018-12, Vol.47 (6), p.1745-1756

2018

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Phase I Pharmacokinetic Study of the Novel Antitumor Agent SR233377

Clinical cancer research, 2000-08, Vol.6 (8), p.3088-3094

2000

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Pharmacokinetic studies in mice of two new thioxanthenones (183577 and 232759) that showed preferential solid tumor activity

Clinical cancer research, 1997-11, Vol.3 (11), p.2047-2053

1997

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Tumor Models and the Discovery and Secondary Evaluation of Solid Tumor Active Agents

International journal of pharmacognosy, 1995, Vol.33 (S1), p.102-122

1995

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Relationship of structure of bridged (2,6-dimethyl-4-pyridinyl)quinolones to mammalian topoisomerase II inhibition

Bioorganic & medicinal chemistry letters, 1993-08, Vol.3 (8), p.1711-1716

1993

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High-performance liquid chromatographic method for the estimation of the novel investigational anti-cancer agent SR271425 and its metabolites in mouse plasma

Journal of chromatography. B, Biomedical sciences and applications, 2001-08, Vol.759 (1), p.175-178

2001

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Reports to the Scientific Grants Committee of the British Medical Association

BMJ, 1890-10, Vol.2 (1556), p.943-954

1890

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Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives

Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative

Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives

Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents

Effects of SW 33377, SW 68210 and SW 71425 thioxanthones on in vitro colony formation of freshly explanted human tumor cells

PARVODICIN, A NOVEL GLYCOPEPTIDE FROM A NEW SPECIES, ACTINOMADURA PARVOSATA: DISCOVERY, TAXONOMY, ACTIVITY AND STRUCTURE ELUCIDATION

AFFINITY OF CEFONICID, A LONG-ACTING CEPHALOSPORIN, FOR THE PENICILLIN-BINDING PROTEINS OF ESCHERICHIA COLI K-12

Neurotensin receptor-mediated inhibition of pancreatic cancer cell growth by the neurotensin antagonist SR 48692

Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)

The antitumor activity of novel pyrazoloquinoline derivatives

Inhibition of platelet-derived growth factor-mediated signal transduction by transforming ras. Suppression of receptor autophosphorylation

Anti-solid tumor efficacy and preparation of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl]methyl]methanesulfonamide (WIN 33377) and related derivatives

Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events

Cyclic variations of SR 233377 (WIN 33377) and effects on antitumor activity

Anti-solid tumor efficacy and preparation of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9 H-thioxanthen-4-yl]methyl]methanesulfonamide (win 33377) and related derivatives

Mechanism of action and antitumor activity of ( S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H-pyridol [1,2,3- de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)

Past and current asbestos exposure and future mesothelioma risks in Britain: The Inhaled Particles Study (TIPS)

Phase I Pharmacokinetic Study of the Novel Antitumor Agent SR233377

Pharmacokinetic studies in mice of two new thioxanthenones (183577 and 232759) that showed preferential solid tumor activity

Tumor Models and the Discovery and Secondary Evaluation of Solid Tumor Active Agents

Relationship of structure of bridged (2,6-dimethyl-4-pyridinyl)quinolones to mammalian topoisomerase II inhibition

High-performance liquid chromatographic method for the estimation of the novel investigational anti-cancer agent SR271425 and its metabolites in mouse plasma

Reports to the Scientific Grants Committee of the British Medical Association

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