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Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives

Journal of medicinal chemistry, 1993-09, Vol.36 (19), p.2801-2809

1993

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Phase I Pharmacokinetic Study of the Novel Antitumor Agent SR233377

Clinical cancer research, 2000-08, Vol.6 (8), p.3088-3094

2000

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Preclinical efficacy of thioxanthone SR271425 against transplanted solid tumors of mouse and human origin

Investigational new drugs, 1999-02, Vol.17 (1), p.17-27

1999

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Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives

Journal of medicinal chemistry, 1998-09, Vol.41 (19), p.3645-3654

1998

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Discovery of cryptophycin-1 and BCN-183577 : Examples of strategies and problems in the detection of antitumor activity in mice

Investigational new drugs, 1997-01, Vol.15 (3), p.207-218

1997

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Effects of SW 33377, SW 68210 and SW 71425 thioxanthones on in vitro colony formation of freshly explanted human tumor cells

Investigational new drugs, 1998-01, Vol.16 (3), p.221-225

1998

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Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents

Journal of medicinal chemistry, 1995-07, Vol.38 (14), p.2531-2540

1995

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Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative

Journal of medicinal chemistry, 1988-09, Vol.31 (9), p.1694-1697

1988

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PARVODICIN, A NOVEL GLYCOPEPTIDE FROM A NEW SPECIES, ACTINOMADURA PARVOSATA: DISCOVERY, TAXONOMY, ACTIVITY AND STRUCTURE ELUCIDATION

The Journal of Antibiotics, 1987/07/25, Vol.40(7), pp.970-990

1987

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Pharmacokinetic studies in mice of two new thioxanthenones (183577 and 232759) that showed preferential solid tumor activity

Clinical cancer research, 1997-11, Vol.3 (11), p.2047-2053

1997

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Neurotensin receptor-mediated inhibition of pancreatic cancer cell growth by the neurotensin antagonist SR 48692

Anticancer research, 1999-01, Vol.19 (1A), p.213

1999

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AFFINITY OF CEFONICID, A LONG-ACTING CEPHALOSPORIN, FOR THE PENICILLIN-BINDING PROTEINS OF ESCHERICHIA COLI K-12

The Journal of Antibiotics, 1984, Vol.37(5), pp.572-576

1984

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Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)

Biochemical pharmacology, 1995-06, Vol.50 (1), p.111-122

1995

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Evidence of enhanced in vivo activity using tirapazamine with paclitaxel and paraplatin regimens against the MV-522 human lung cancer xenograft

Cancer chemotherapy and pharmacology, 1999, Vol.43 (5), p.402-408

1999

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The antitumor activity of novel pyrazoloquinoline derivatives

Bioorganic & medicinal chemistry letters, 1995-02, Vol.5 (4), p.405-410

1995

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Inhibition of platelet-derived growth factor-mediated signal transduction by transforming ras. Suppression of receptor autophosphorylation

The Journal of biological chemistry, 1991-03, Vol.266 (8), p.5348-5352

1991

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Anti-solid tumor efficacy and preparation of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl]methyl]methanesulfonamide (WIN 33377) and related derivatives

Bioorganic & medicinal chemistry letters, 1994-02, Vol.4 (4), p.609-614

1994

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Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events

The Journal of biological chemistry, 1991-07, Vol.266 (21), p.14055-14063

1991

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Cyclic variations of SR 233377 (WIN 33377) and effects on antitumor activity

Bioorganic & medicinal chemistry letters, 1996-06, Vol.6 (12), p.1345-1350

1996

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Tumor Models and the Discovery and Secondary Evaluation of Solid Tumor Active Agents

International journal of pharmacognosy, 1995, Vol.33 (S1), p.102-122

1995

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Anti-solid tumor efficacy and preparation of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9 H-thioxanthen-4-yl]methyl]methanesulfonamide (win 33377) and related derivatives

Bioorganic & medicinal chemistry letters, 1994, Vol.4 (4), p.609-614

1994

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Antitumour activity of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl]methyl]methanesulfonamide (WIN33377) and analogues

Expert opinion on investigational drugs, 1994-12, Vol.3 (12), p.1281-1292

1994

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Mechanism of action and antitumor activity of ( S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H-pyridol [1,2,3- de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)

Biochemical pharmacology, 1995-06, Vol.50 (1), p.111-122

1995

Volltextzugriff (PDF)

Relationship of structure of bridged (2,6-dimethyl-4-pyridinyl)quinolones to mammalian topoisomerase II inhibition

Bioorganic & medicinal chemistry letters, 1993-08, Vol.3 (8), p.1711-1716

1993

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METAL RESISTANCE IN ALCALIGENES MARINUS BY PRODUCTION OF EXTRACELLULAR BINDING AGENTS

RAKE, JAMES BEAVEN

1978

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Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives

Phase I Pharmacokinetic Study of the Novel Antitumor Agent SR233377

Preclinical efficacy of thioxanthone SR271425 against transplanted solid tumors of mouse and human origin

Synthesis and Antitumor Activity of 4-Aminomethylthioxanthenone and 5-Aminomethylbenzothiopyranoindazole Derivatives

Discovery of cryptophycin-1 and BCN-183577 : Examples of strategies and problems in the detection of antitumor activity in mice

Effects of SW 33377, SW 68210 and SW 71425 thioxanthones on in vitro colony formation of freshly explanted human tumor cells

Synthesis and Antibacterial Activity of Some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents

Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative

PARVODICIN, A NOVEL GLYCOPEPTIDE FROM A NEW SPECIES, ACTINOMADURA PARVOSATA: DISCOVERY, TAXONOMY, ACTIVITY AND STRUCTURE ELUCIDATION

Pharmacokinetic studies in mice of two new thioxanthenones (183577 and 232759) that showed preferential solid tumor activity

Neurotensin receptor-mediated inhibition of pancreatic cancer cell growth by the neurotensin antagonist SR 48692

AFFINITY OF CEFONICID, A LONG-ACTING CEPHALOSPORIN, FOR THE PENICILLIN-BINDING PROTEINS OF ESCHERICHIA COLI K-12

Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)

Evidence of enhanced in vivo activity using tirapazamine with paclitaxel and paraplatin regimens against the MV-522 human lung cancer xenograft

The antitumor activity of novel pyrazoloquinoline derivatives

Inhibition of platelet-derived growth factor-mediated signal transduction by transforming ras. Suppression of receptor autophosphorylation

Anti-solid tumor efficacy and preparation of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl]methyl]methanesulfonamide (WIN 33377) and related derivatives

Dissociation of platelet-derived growth factor (PDGF) receptor autophosphorylation from other PDGF-mediated second messenger events

Cyclic variations of SR 233377 (WIN 33377) and effects on antitumor activity

Tumor Models and the Discovery and Secondary Evaluation of Solid Tumor Active Agents

Anti-solid tumor efficacy and preparation of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9 H-thioxanthen-4-yl]methyl]methanesulfonamide (win 33377) and related derivatives

Antitumour activity of N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxo-9H-thioxanthen-4-yl]methyl]methanesulfonamide (WIN33377) and analogues

Mechanism of action and antitumor activity of ( S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H-pyridol [1,2,3- de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)

Relationship of structure of bridged (2,6-dimethyl-4-pyridinyl)quinolones to mammalian topoisomerase II inhibition

METAL RESISTANCE IN ALCALIGENES MARINUS BY PRODUCTION OF EXTRACELLULAR BINDING AGENTS

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