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Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA -Mutant Ovarian Cancer Models

Clinical cancer research, 2017-06, Vol.23 (12), p.3097-3108

2017

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RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells

Genes & development, 2013-10, Vol.27 (20), p.2259-2273

2013

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Combining ATR Suppression with Oncogenic Ras Synergistically Increases Genomic Instability, Causing Synthetic Lethality or Tumorigenesis in a Dosage-Dependent Manner

Cancer research (Chicago, Ill.), 2010-12, Vol.70 (23), p.9693-9702

2010

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Differential Roles for DNA Polymerases Eta, Zeta, and REV1 in Lesion Bypass of Intrastrand versus Interstrand DNA Cross-Links

Molecular and Cellular Biology, 2010-03, Vol.30 (5), p.1217-1230

2010

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Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage-induced cytokine production

Science signaling, 2021-12, Vol.14 (714), p.eaba2611

2021

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Replication stress induces tumor-like microdeletions in FHIT/FRA3B

Proceedings of the National Academy of Sciences - PNAS, 2008-01, Vol.105 (1), p.246-251

2008

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Common fragile sites as targets for chromosome rearrangements

DNA repair, 2006-09, Vol.5 (9), p.1126-1135

2006

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Replication Stress Induces Genome-wide Copy Number Changes in Human Cells that Resemble Polymorphic and Pathogenic Variants

American journal of human genetics, 2009-03, Vol.84 (3), p.339-350

2009

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Middle-School Student Engagement in a Tick Testing Community Science Project

Insects (Basel, Switzerland), 2021-12, Vol.12 (12), p.1136

2021

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Analysis of light quality and assemblage composition on diatom motility and accumulation rate

Diatom research, 2016-07, Vol.31 (3), p.173-184

2016

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Stably transfected common fragile site sequences exhibit instability at ectopic sites

Genes chromosomes & cancer, 2008-10, Vol.47 (10), p.860-872

2008

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Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response

Mammalian genome, 2009-06, Vol.20 (6), p.375-385

2009

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Abstract 3498: Highly specific macrocyclic ATR inhibitors for the targeted treatment of a broad spectrum of cancers showing lack of anemia or neutropenia in pre-clinical animal models

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3498-3498

2019

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Targeting the ATR/CHK1 axis with PARP inhibition results in tumor regression in BRCA mutant models

Clinical cancer research, 2016-12, Vol.23 (12), p.3097-3108

2016

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Abstract 1226: Highly specific ATR inhibitors as a therapeutic approach for a broad spectrum of cancers

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1226-1226

2016

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CHARACTERISATION OF THE DIATOM PHOTOPHOBIC RESPONSE TO HIGH IRRADIANCE

Diatom research, 2004-01, Vol.19 (2), p.167-179

2004

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Abstract 4835: Targeting the ATR/CHK1 axis in combination with PARP inhibition is more effective than PARP inhibition alone in BRCA mutant models

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4835-4835

2016

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Abstract A16: Potent and selective ATR inhibitors for the treatment of homologous-recombination deficient and PARPi-resistant cancers

Molecular cancer research, 2017-04, Vol.15 (4_Supplement), p.A16-A16

2017

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169: IL-19, a novel SASP factor, is upregulated during senescence and in response to DSBs

Cytokine (Philadelphia, Pa.), 2014-11, Vol.70 (1), p.69-69

2014

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Abstract A02: A novel orthotopic ovarian patient derived xenograft model platform to investigate novel therapies for BRCA deficient ovarian cancers

Clinical cancer research, 2016-08, Vol.22 (16_Supplement), p.A02-A02

2016

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THE EFFECT OF TEMPERATURE AND MIXED SPECIES COMPOSITION ON DIATOM MOTILITY AND ADHESION

Diatom research, 2003-11, Vol.18 (2), p.225-243

2003

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Common fragile sites as targets for chromosome rearrangements: Mechanisms of chromosomal translocation

DNA repair, 2006, Vol.5 (9-10), p.1126-1135

2006

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Mechanisms of common fragile site instability and cancer

Ragland, Ryan L

2009

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Fragile Sites

Encyclopedia of Cancer, p.1786-1790

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Clinical and functional outcomes after 2 years in the early detection and intervention for the prevention of psychosis multisite effectiveness trial

Schizophrenia bulletin, 2015-01, Vol.41 (1), p.30-43

2015

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Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA -Mutant Ovarian Cancer Models

RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells

Combining ATR Suppression with Oncogenic Ras Synergistically Increases Genomic Instability, Causing Synthetic Lethality or Tumorigenesis in a Dosage-Dependent Manner

Differential Roles for DNA Polymerases Eta, Zeta, and REV1 in Lesion Bypass of Intrastrand versus Interstrand DNA Cross-Links

Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage-induced cytokine production

Replication stress induces tumor-like microdeletions in FHIT/FRA3B

Common fragile sites as targets for chromosome rearrangements

Replication Stress Induces Genome-wide Copy Number Changes in Human Cells that Resemble Polymorphic and Pathogenic Variants

Middle-School Student Engagement in a Tick Testing Community Science Project

Analysis of light quality and assemblage composition on diatom motility and accumulation rate

Stably transfected common fragile site sequences exhibit instability at ectopic sites

Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response

Abstract 3498: Highly specific macrocyclic ATR inhibitors for the targeted treatment of a broad spectrum of cancers showing lack of anemia or neutropenia in pre-clinical animal models

Targeting the ATR/CHK1 axis with PARP inhibition results in tumor regression in BRCA mutant models

Abstract 1226: Highly specific ATR inhibitors as a therapeutic approach for a broad spectrum of cancers

CHARACTERISATION OF THE DIATOM PHOTOPHOBIC RESPONSE TO HIGH IRRADIANCE

Abstract 4835: Targeting the ATR/CHK1 axis in combination with PARP inhibition is more effective than PARP inhibition alone in BRCA mutant models

Abstract A16: Potent and selective ATR inhibitors for the treatment of homologous-recombination deficient and PARPi-resistant cancers

169: IL-19, a novel SASP factor, is upregulated during senescence and in response to DSBs

Abstract A02: A novel orthotopic ovarian patient derived xenograft model platform to investigate novel therapies for BRCA deficient ovarian cancers

THE EFFECT OF TEMPERATURE AND MIXED SPECIES COMPOSITION ON DIATOM MOTILITY AND ADHESION

Common fragile sites as targets for chromosome rearrangements: Mechanisms of chromosomal translocation

Mechanisms of common fragile site instability and cancer

Fragile Sites

Clinical and functional outcomes after 2 years in the early detection and intervention for the prevention of psychosis multisite effectiveness trial

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