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ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase

PloS one, 2016-12, Vol.11 (12), p.e0168739

2016

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The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues

Molecules (Basel, Switzerland), 2019-07, Vol.24 (13), p.2510

2019

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Discovery of 5‑Substituted Pyrrolo[2,3‑d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10016-10032

2013

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DDDR-11. TREATING DIPG WITH A MITOCHONDRIALLY TARGETED PLATINUM(IV)-BASED PRODRUG

Neuro-oncology (Charlottesville, Va.), 2022-11, Vol.24 (Supplement_7), p.vii100-vii101

2022

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DDRE-17. TARGETING GLIOBLASTOMA’S GALACTOSE SCAVENGING PATHWAY

Neuro-oncology (Charlottesville, Va.), 2021-11, Vol.23 (Supplement_6), p.vi78-vi78

2021

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460 MP-Pt(IV): A Platinum (IV)-Based Prodrug for Treating DIPG With Selective Mitochondrial Chemotherapy

Neurosurgery, 2023-04, Vol.69 (Supplement_1), p.95-96

2023

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EXTH-72. MP-Pt(IV): A MAOB SENSITIVE MITOCHONDRIAL SMART BOMB FOR TREATING GLIOMA

Neuro-oncology (Charlottesville, Va.), 2018-11, Vol.20 (suppl_6), p.vi100-vi100

2018

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MP-Pt(IV): A MAOB-Sensitive Mitochondrial-Specific Prodrug for Treating Glioblastoma

Molecular cancer therapeutics, 2020-12, Vol.19 (12), p.2445-2453

2020

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Abstract 1362: Novel proton coupled folate transporter (PCFT) and reduced folate carrier (RFC) pharmacophore models for development of transporter-selective antifolates

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.1362-1362

2016

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The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (10), p.2408-2423

2015

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A "Clickable" Probe for Active MGMT in Glioblastoma Demonstrates Two Discrete Populations of MGMT

Cancers, 2020-02, Vol.12 (2), p.453

2020

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Prodrugs of a 1‑Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers

Journal of medicinal chemistry, 2022-10, Vol.65 (20), p.13813-13832

2022

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PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma

Oncotarget, 2018-05, Vol.9 (35), p.23923-23943

2018

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Targeting the Leloir Pathway with Galactose-Based Antimetabolites in Glioblastoma

Cancers, 2024-10, Vol.16 (20), p.3510

2024

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Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3‑d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4422-4441

2013

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Novel 5‑Substituted Pyrrolo[2,3‑d]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase and as Potential Antitumor Agents

Journal of medicinal chemistry, 2015-02, Vol.58 (3), p.1479-1493

2015

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Synthesis and Discovery of Water-Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance

Journal of medicinal chemistry, 2010-11, Vol.53 (22), p.8116-8128

2010

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Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido[4,5-b]indoles as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1563-1578

2010

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6‑Substituted Pyrrolo[2,3‑d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.6938-6959

2015

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Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores)

Journal of molecular graphics & modelling, 2018-05, Vol.81, p.125-133

2018

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Tumor-Targeting with Novel Non-Benzoyl 6‑Substituted Straight Chain Pyrrolo[2,3‑d]pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and Inhibition of de Novo Purine Nucleotide Biosynthesis

Journal of medicinal chemistry, 2013-11, Vol.56 (21), p.8684-8695

2013

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Structure–Activity Profiles of Novel 6‑Substituted Pyrrolo[2,3‑d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter

Journal of medicinal chemistry, 2014-10, Vol.57 (19), p.8152-8166

2014

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Structure–Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-microtubule Agent N‑(4-Methoxyphenyl)‑N,2,6-trimethyl-6,7-dihydro‑5H‑cyclopenta[d]pyrimidin-4-aminium Chloride and Its Analogues As Antitumor Agents

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.6829-6844

2013

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Tumor Targeting with Novel 6‑Substituted Pyrrolo [2,3‑d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7856-7876

2016

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The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents

Bioorganic & medicinal chemistry, 2014-07, Vol.22 (14), p.3753-3772

2014

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ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase

The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues

DDDR-11. TREATING DIPG WITH A MITOCHONDRIALLY TARGETED PLATINUM(IV)-BASED PRODRUG

DDRE-17. TARGETING GLIOBLASTOMA’S GALACTOSE SCAVENGING PATHWAY

460 MP-Pt(IV): A Platinum (IV)-Based Prodrug for Treating DIPG With Selective Mitochondrial Chemotherapy

EXTH-72. MP-Pt(IV): A MAOB SENSITIVE MITOCHONDRIAL SMART BOMB FOR TREATING GLIOMA

MP-Pt(IV): A MAOB-Sensitive Mitochondrial-Specific Prodrug for Treating Glioblastoma

Abstract 1362: Novel proton coupled folate transporter (PCFT) and reduced folate carrier (RFC) pharmacophore models for development of transporter-selective antifolates

The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents

A "Clickable" Probe for Active MGMT in Glioblastoma Demonstrates Two Discrete Populations of MGMT

Prodrugs of a 1‑Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers

PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma

Targeting the Leloir Pathway with Galactose-Based Antimetabolites in Glioblastoma

Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3‑d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles

Novel 5‑Substituted Pyrrolo[2,3‑d]pyrimidines as Dual Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5‑Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase and as Potential Antitumor Agents

Synthesis and Discovery of Water-Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance

Single Agents with Designed Combination Chemotherapy Potential: Synthesis and Evaluation of Substituted Pyrimido[4,5-b]indoles as Receptor Tyrosine Kinase and Thymidylate Synthase Inhibitors and as Antitumor Agents

6‑Substituted Pyrrolo[2,3‑d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors

Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores)

Tumor-Targeting with Novel Non-Benzoyl 6‑Substituted Straight Chain Pyrrolo[2,3‑d]pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and Inhibition of de Novo Purine Nucleotide Biosynthesis

Structure–Activity Profiles of Novel 6‑Substituted Pyrrolo[2,3‑d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter

Structure–Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-microtubule Agent N‑(4-Methoxyphenyl)‑N,2,6-trimethyl-6,7-dihydro‑5H‑cyclopenta[d]pyrimidin-4-aminium Chloride and Its Analogues As Antitumor Agents

Tumor Targeting with Novel 6‑Substituted Pyrrolo [2,3‑d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis

The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents

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