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Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer

Journal of mammary gland biology and neoplasia, 2010-06, Vol.15 (2), p.201-212

2010

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FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Nature communications, 2020-03, Vol.11 (1), p.1318-1318, Article 1318

2020

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Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site

PloS one, 2021-11, Vol.16 (11), p.e0249616-e0249616

2021

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Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H

The Journal of clinical investigation, 2020-01, Vol.130 (1), p.189-202

2020

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Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

PloS one, 2012-04, Vol.7 (4), p.e35040

2012

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Mirolysin structures open a window on gum disease

IUCrJ, 2020-01, Vol.7 (Pt 1), p.3-4

Radisky, Evette S

2020

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Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

Scientific reports, 2023-03, Vol.13 (1), p.5186-5186, Article 5186

2023

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Extracellular proteolysis in cancer: Proteases, substrates, and mechanisms in tumor progression and metastasis

The Journal of biological chemistry, 2024-06, Vol.300 (6), p.107347, Article 107347

Radisky, Evette S.

2024

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Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

Science translational medicine, 2012-07, Vol.4 (142), p.142ra95

2012

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Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Nature communications, 2018-09, Vol.9 (1), p.3935-10, Article 3935

2018

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Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes

PloS one, 2013-09, Vol.8 (9), p.e75836-e75836

2013

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Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109

Breast cancer research and treatment, 2010-11, Vol.124 (1), p.27-38

2010

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Bad Tumors Made Worse: SPINK1

Frontiers in cell and developmental biology, 2019-02, Vol.7, p.10-10

2019

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Small molecule inhibitors of mesotrypsin from a structure-based docking screen

PloS one, 2017-05, Vol.12 (5), p.e0176694

2017

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Stromal induction of breast cancer: inflammation and invasion

Reviews in endocrine & metabolic disorders, 2007-09, Vol.8 (3), p.279-287

2007

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PEGylation extends circulation half-life while preserving in vitro and in vivo activity of tissue inhibitor of metalloproteinases-1 (TIMP-1)

PloS one, 2012-11, Vol.7 (11), p.e50028-e50028

2012

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Structure and computation-guided yeast surface display for the evolution of TIMP-based matrix metalloproteinase inhibitors

Frontiers in molecular biosciences, 2023, Vol.10, p.1321956-1321956

2023

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Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension

Biomolecules (Basel, Switzerland), 2024-09, Vol.14 (9), p.1187

2024

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Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids

PloS one, 2014-07, Vol.9 (7), p.e102063-e102063

2014

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EGFR as a prognostic biomarker and therapeutic target in ovarian cancer: evaluation of patient cohort and literature review

Genes & cancer, 2017-05, Vol.8 (5-6), p.589-599

2017

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Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

Oncotarget, 2014-05, Vol.5 (9), p.2736-2749

2014

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Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation

The Journal of biological chemistry, 2013-04, Vol.288 (14), p.9848-9859

2013

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Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement

Biomolecules (Basel, Switzerland), 2021-05, Vol.11 (6), p.787

2021

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Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer

Journal of cellular biochemistry, 2017-11, Vol.118 (11), p.3531-3548

2017

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Insights into the Serine Protease Mechanism from Atomic Resolution Structures of Trypsin Reaction Intermediates

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (18), p.6835-6840

2006

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Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site

Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

Mirolysin structures open a window on gum disease

Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14

Extracellular proteolysis in cancer: Proteases, substrates, and mechanisms in tumor progression and metastasis

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Matrix metalloproteinase-10/TIMP-2 structure and analyses define conserved core interactions and diverse exosite interactions in MMP/TIMP complexes

Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109

Bad Tumors Made Worse: SPINK1

Small molecule inhibitors of mesotrypsin from a structure-based docking screen

Stromal induction of breast cancer: inflammation and invasion

PEGylation extends circulation half-life while preserving in vitro and in vivo activity of tissue inhibitor of metalloproteinases-1 (TIMP-1)

Structure and computation-guided yeast surface display for the evolution of TIMP-based matrix metalloproteinase inhibitors

Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension

Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids

EGFR as a prognostic biomarker and therapeutic target in ovarian cancer: evaluation of patient cohort and literature review

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation

Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement

Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer

Insights into the Serine Protease Mechanism from Atomic Resolution Structures of Trypsin Reaction Intermediates

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