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GNS561 Exhibits Potent Antiviral Activity against SARS-CoV-2 through Autophagy Inhibition

Viruses, 2022-01, Vol.14 (1), p.132

2022

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GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

Therapeutic advances in chronic disease, 2020, Vol.11, p.2040622320942042-2040622320942042

2020

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First-In-Human Effects of PPT1 Inhibition Using the Oral Treatment with GNS561/Ezurpimtrostat in Patients with Primary and Secondary Liver Cancers

Liver cancer (Basel ), 2022-06, Vol.11 (3), p.268-277

2022

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Abstract 899: Remarkable anti-tumor response in a HCC transgenic mouse model treated with GNS561 in combination with anti-PD1

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.899-899

2020

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Targeting p53-dependent stem cell loss for intestinal chemoprotection

Science translational medicine, 2018-02, Vol.10 (427)

2018

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First-in-human phase I, pharmacokinetic (PK), and pharmacodynamic (PD) study of oral GNS561, a palmitoyl-protein thioesterase 1 (PPT1) inhibitor, in patients with primary and secondary liver malignancies

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.e16175-e16175

2021

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Ezurpimtrostat, A Palmitoyl-Protein Thioesterase-1 Inhibitor, Combined with PD-1 Inhibition Provides CD8+ Lymphocyte Repopulation in Hepatocellular Carcinoma

Targeted oncology, 2024-01, Vol.19 (1), p.95-106

2024

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LC–MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma

Journal of pharmaceutical and biomedical analysis, 2017-05, Vol.138, p.158-165

2017

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Abstract 5479: PGx of gemcitabine in pancreatic ADK: Where did we go wrong

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5479-5479

2015

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Population Pharmacokinetics of Gemcitabine and dFdU in Pancreatic Cancer Patients Using an Optimal Design, Sparse Sampling Approach

Therapeutic drug monitoring, 2017-06, Vol.39 (3), p.290

2017

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Phase I study of veliparib in combination with gemcitabine

Cancer chemotherapy and pharmacology, 2017-09, Vol.80 (3), p.631-643

2017

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GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

Therapeutic advances in chronic disease, 2020-01, Vol.11

2020

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Chemical Composition Profiling and Antifungal Activity of Saffron Petal Extract

Molecules (Basel, Switzerland), 2022-12, Vol.27 (24), p.8742

2022

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A deterministic method for continuous global optimization using a dense curve

Mathematics and computers in simulation, 2020-12, Vol.178, p.62-91

2020

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Numerical investigation on the wall-coated steam methane reformer improvement: Effects of catalyst layer patterns and metal foam insertion

International journal of hydrogen energy, 2015-08, Vol.40 (29), p.8966-8979

2015

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Impact of Ni-based catalyst patterning on hydrogen production from MSR: External steam reformer modelling

International journal of hydrogen energy, 2019-04, Vol.44 (22), p.11346-11354

2019

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Flavonoid Composition and Antibacterial Properties of Crocus sativus L. Petal Extracts

Molecules (Basel, Switzerland), 2022-12, Vol.28 (1), p.186

2022

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Global optimization through a stochastic perturbation of the Polak–Ribière conjugate gradient method

Journal of computational and applied mathematics, 2017-06, Vol.317, p.672-684

2017

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Numerical study on the effects of the macropatterned active surfaces on the wall-coated steam methane reformer performances

International journal of hydrogen energy, 2017-01, Vol.42 (2), p.1490-1498

2017

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Optimization of the results of a multilingual search engine using a fuzzy recommendation approach

Journal of Information and Organizational Sciences, 2023-01, Vol.47 (2), p.423-443

2023

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MDA4SOA+d: A new model driven architecture to supporting decision making in SOA

Journal of King Saud University. Computer and information sciences, 2023-05, Vol.35 (5), p.101544, Article 101544

2023

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Real-World Efficacy and Toxicity of the LMBA02 Protocol for Burkitt Lymphoma in Morocco

Clinical lymphoma, myeloma and leukemia, 2024-09, Vol.24, p.S215-S215

2024

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Clinical-Biologic Features and Treatment Outcomes of Children With Lymphoblastic Lymphomas in Morocco

Clinical lymphoma, myeloma and leukemia, 2024-09, Vol.24, p.S160-S160

2024

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ALL-331 Clinical-Biologic Features and Treatment Outcomes of Children With Lymphoblastic Lymphomas in Morocco

Clinical lymphoma, myeloma and leukemia, 2024-09, Vol.24, p.S266-S267

2024

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GNS561 Exhibits Potent Antiviral Activity against SARS-CoV-2 through Autophagy Inhibition

GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

First-In-Human Effects of PPT1 Inhibition Using the Oral Treatment with GNS561/Ezurpimtrostat in Patients with Primary and Secondary Liver Cancers

Abstract 899: Remarkable anti-tumor response in a HCC transgenic mouse model treated with GNS561 in combination with anti-PD1

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

Targeting p53-dependent stem cell loss for intestinal chemoprotection

First-in-human phase I, pharmacokinetic (PK), and pharmacodynamic (PD) study of oral GNS561, a palmitoyl-protein thioesterase 1 (PPT1) inhibitor, in patients with primary and secondary liver malignancies

Ezurpimtrostat, A Palmitoyl-Protein Thioesterase-1 Inhibitor, Combined with PD-1 Inhibition Provides CD8+ Lymphocyte Repopulation in Hepatocellular Carcinoma

LC–MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma

Abstract 5479: PGx of gemcitabine in pancreatic ADK: Where did we go wrong

Population Pharmacokinetics of Gemcitabine and dFdU in Pancreatic Cancer Patients Using an Optimal Design, Sparse Sampling Approach

Phase I study of veliparib in combination with gemcitabine

GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

Chemical Composition Profiling and Antifungal Activity of Saffron Petal Extract

A deterministic method for continuous global optimization using a dense curve

Numerical investigation on the wall-coated steam methane reformer improvement: Effects of catalyst layer patterns and metal foam insertion

Impact of Ni-based catalyst patterning on hydrogen production from MSR: External steam reformer modelling

Flavonoid Composition and Antibacterial Properties of Crocus sativus L. Petal Extracts

Global optimization through a stochastic perturbation of the Polak–Ribière conjugate gradient method

Numerical study on the effects of the macropatterned active surfaces on the wall-coated steam methane reformer performances

Optimization of the results of a multilingual search engine using a fuzzy recommendation approach

MDA4SOA+d: A new model driven architecture to supporting decision making in SOA

Real-World Efficacy and Toxicity of the LMBA02 Protocol for Burkitt Lymphoma in Morocco

Clinical-Biologic Features and Treatment Outcomes of Children With Lymphoblastic Lymphomas in Morocco

ALL-331 Clinical-Biologic Features and Treatment Outcomes of Children With Lymphoblastic Lymphomas in Morocco

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