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Understanding and applying regulatory guidance on the nonclinical development of biotechnology-derived pharmaceuticals

BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy, 2006, Vol.20 (1), p.25-52

2006

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Justification for routine screening of pharmaceutical products in immune function tests: a review of the recommendations of Putman et al. (2003)

Fundamental & clinical pharmacology, 2005-06, Vol.19 (3), p.317-322

Ryle, Peter R.

2005

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Implementation of ICH S6: EU Perspective

Preclinical Safety Evaluation of Biopharmaceuticals, 2008, p.67-92

2008

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The role of the hepatocellular redox state in the hepatic triglyceride accumulation following acute ethanol administration

Biochemical pharmacology, 1986-09, Vol.35 (18), p.3159-3164

1986

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FREE RADICALS, LIPID PEROXIDATION, AND ETHANOL HEPATOTOXICITY

The Lancet (British edition), 1984-08, Vol.324 (8400), p.461-461

Ryle, PeterR

1984

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HEPATIC REDOX STATE ALTERATIONS AS A MECHANISM OF FATTY LIVER PRODUCTION AFTER ETHANOL: FACT OR FICTION?

Alcohol and alcoholism (Oxford), 1986, Vol.21 (2), p.131-135

Ryle, P R

1986

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MALOTILATE: THE NEW HOPE FOR A CLINICALLY EFFECTIVE AGENT FOR THE TREATMENT OF LIVER DISEASE

Alcohol and alcoholism (Oxford), 1987, Vol.22 (2), p.121-141

1987

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The effect of di-isopropyl 1,3 dithiol-2-ylidenemalonate (Malotilate) on the hepatic changes induced by ethanol administration in the rat

Biochemical pharmacology, 1988-11, Vol.37 (22), p.4341-4351

1988

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The roles of the hepatocellular redox state and the hepatic acetaldehyde concentration in determining the ethanol elimination rate in fasted rats

Biochemical pharmacology, 1985-10, Vol.34 (19), p.3577-3583

1985

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ACETALDEHYDE AND THE FETAL ALCOHOL SYNDROME

The Lancet (British edition), 1983-07, Vol.322 (8343), p.219-220

1983

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Inhibition of ethanol induced hepatic vitamin A depletion by administration of N, N′-diphenyl-P-phenylene-diamine (DPPD)

Life sciences (1973), 1986-02, Vol.38 (8), p.695-702

1986

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THE EFFECT OF NALOXONE ON THE HEPATOCELLULAR REDOX STATE AND SERUM ETHANOL CONCENTRATIONS FOLLOWING ACUTE ETHANOL ADMINISTRATION

Alcohol and alcoholism (Oxford), 1985, Vol.20 (3), p.287-291

1985

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A COMPARATIVE STUDY OF THE EFFECTS OF ( + )-CATECHIN AND 3-PALMITOYL-( + )-CATECHIN ON ALCOHOLIC FATTY LIVER IN THE RAT

Alcohol and alcoholism (Oxford), 1983, Vol.18 (3), p.239-248

1983

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ALCOHOL AND BODY WEIGHT

Alcohol and alcoholism (Oxford), 1984, Vol.19 (1), p.1-6

1984

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DIFFERENTIAL EFFECT OF CHRONIC ALCOHOL INTAKE AND POOR NUTRITION ON BODY WEIGHT AND FAT STORES

Alcohol and alcoholism (Oxford), 1984, Vol.19 (4), p.281-290

1984

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Subacute toxicity of a Pseudomonas vaccine prepared from outer membrane fraction of Pseudomonas aeruginosa in beagle dogs

Arzneimittel-Forschung, 1997-01, Vol.47 (1), p.80

1997

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X-ray Crystal Structure of Escherichia coli Taurine/α-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates

Biochemistry (Easton), 2002-04, Vol.41 (16), p.5185-5192

2002

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German Unification: Expectations and Outcomes

1, 2011

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Understanding and applying regulatory guidance on the nonclinical development of biotechnology-derived pharmaceuticals

Justification for routine screening of pharmaceutical products in immune function tests: a review of the recommendations of Putman et al. (2003)

Implementation of ICH S6: EU Perspective

The role of the hepatocellular redox state in the hepatic triglyceride accumulation following acute ethanol administration

FREE RADICALS, LIPID PEROXIDATION, AND ETHANOL HEPATOTOXICITY

HEPATIC REDOX STATE ALTERATIONS AS A MECHANISM OF FATTY LIVER PRODUCTION AFTER ETHANOL: FACT OR FICTION?

MALOTILATE: THE NEW HOPE FOR A CLINICALLY EFFECTIVE AGENT FOR THE TREATMENT OF LIVER DISEASE

The effect of di-isopropyl 1,3 dithiol-2-ylidenemalonate (Malotilate) on the hepatic changes induced by ethanol administration in the rat

The roles of the hepatocellular redox state and the hepatic acetaldehyde concentration in determining the ethanol elimination rate in fasted rats

ACETALDEHYDE AND THE FETAL ALCOHOL SYNDROME

Inhibition of ethanol induced hepatic vitamin A depletion by administration of N, N′-diphenyl-P-phenylene-diamine (DPPD)

THE EFFECT OF NALOXONE ON THE HEPATOCELLULAR REDOX STATE AND SERUM ETHANOL CONCENTRATIONS FOLLOWING ACUTE ETHANOL ADMINISTRATION

A COMPARATIVE STUDY OF THE EFFECTS OF ( + )-CATECHIN AND 3-PALMITOYL-( + )-CATECHIN ON ALCOHOLIC FATTY LIVER IN THE RAT

ALCOHOL AND BODY WEIGHT

DIFFERENTIAL EFFECT OF CHRONIC ALCOHOL INTAKE AND POOR NUTRITION ON BODY WEIGHT AND FAT STORES

Subacute toxicity of a Pseudomonas vaccine prepared from outer membrane fraction of Pseudomonas aeruginosa in beagle dogs

X-ray Crystal Structure of Escherichia coli Taurine/α-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates

German Unification: Expectations and Outcomes

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