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Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Nature reviews. Drug discovery, 2019-04, Vol.18 (4), p.295-317

2019

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Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

Scientific reports, 2022-08, Vol.12 (1), p.14685-14685, Article 14685

2022

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Cell-free DNA levels associate with COPD exacerbations and mortality

Respiratory research, 2024-01, Vol.25 (1), p.42-42, Article 42

2024

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Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases

The Journal of pharmacology and experimental therapeutics, 2013-05, Vol.345 (2), p.260-270

2013

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Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention

Free radical biology & medicine, 2018-08, Vol.124, p.149-162

2018

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Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs

Mutagenesis, 2017-05, Vol.32 (3), p.343

2017

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Structural Analysis and Optimization of NK1 Receptor Antagonists through Modulation of Atropisomer Interconversion Properties

Journal of medicinal chemistry, 2004-01, Vol.47 (3), p.519-529

2004

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3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

ACS medicinal chemistry letters, 2018-12, Vol.9 (12), p.1164-1169

2018

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Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists

Bioorganic & medicinal chemistry, 2004-05, Vol.12 (10), p.2653-2669

2004

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4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (16), p.5222-5226

2012

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Discovery of novel, orally active dual NK1/NK2 antagonists

Bioorganic & medicinal chemistry letters, 2001-10, Vol.11 (20), p.2769-2773

2001

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The Role of IκB Kinase 2, but Not Activation of NF-κB, in the Release of CXCR3 Ligands from IFN-γ-Stimulated Human Bronchial Epithelial Cells

The Journal of immunology (1950), 2007-11, Vol.179 (9), p.6237-6245

2007

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Progress Towards the Development of Anti-Inflammatory Inhibitors of IKKβ

Current topics in medicinal chemistry, 2009-05, Vol.9 (7), p.623-639

2009

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3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2255-2258

2011

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Design and optimization of cyclized NK1 antagonists with controlled atropisomeric properties

Tetrahedron, 2004-05, Vol.60 (20), p.4337-4347

2004

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Adaptation to hypoxia alters energy metabolism in rat heart

American journal of physiology. Heart and circulatory physiology, 1999-01, Vol.276 (1), p.H71-H80

1999

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Imaging of Phosphorescence: A Novel Method for Measuring Oxygen Distribution in Perfused Tissue

Science (American Association for the Advancement of Science), 1988-09, Vol.241 (4873), p.1649-1651

1988

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Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors

The Journal of pharmacology and experimental therapeutics, 2001-07, Vol.298 (1), p.307

2001

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3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IIK-β

Bioorganic & medicinal chemistry letters, 2011, Vol.21 (8), p.2255-2258

2011

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The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells

The Journal of immunology (1950), 2007-11, Vol.179 (9), p.6237-6245

2007

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Cellular energetics and the oxygen dependence of respiration in cardiac myocytes isolated from adult rat

The Journal of biological chemistry, 1990-09, Vol.265 (26), p.15392-15399

1990

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The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. part 1

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (17), p.1949-1952

2000

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Imaging of Phosphorescence: A Novel Method for Measuring Oxygen Distribution in Perfused Tissue

Science (American Association for the Advancement of Science), 1988-09, Vol.241 (4873), p.1649-1651

1988

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Design and optimization of cyclized NK 1 antagonists with controlled atropisomeric properties

Tetrahedron, 2004, Vol.60 (20), p.4337-4347

2004

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Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

Cell-free DNA levels associate with COPD exacerbations and mortality

Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases

Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1/NRF2) Protein–Protein Interaction

Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention

Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs

Structural Analysis and Optimization of NK1 Receptor Antagonists through Modulation of Atropisomer Interconversion Properties

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists

4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

Discovery of novel, orally active dual NK1/NK2 antagonists

The Role of IκB Kinase 2, but Not Activation of NF-κB, in the Release of CXCR3 Ligands from IFN-γ-Stimulated Human Bronchial Epithelial Cells

Progress Towards the Development of Anti-Inflammatory Inhibitors of IKKβ

3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β

Design and optimization of cyclized NK1 antagonists with controlled atropisomeric properties

Adaptation to hypoxia alters energy metabolism in rat heart

Imaging of Phosphorescence: A Novel Method for Measuring Oxygen Distribution in Perfused Tissue

Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors

3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IIK-β

The role of IkappaB kinase 2, but not activation of NF-kappaB, in the release of CXCR3 ligands from IFN-gamma-stimulated human bronchial epithelial cells

Cellular energetics and the oxygen dependence of respiration in cardiac myocytes isolated from adult rat

The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. part 1

Imaging of Phosphorescence: A Novel Method for Measuring Oxygen Distribution in Perfused Tissue

Design and optimization of cyclized NK 1 antagonists with controlled atropisomeric properties

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