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Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Nature reviews. Drug discovery, 2019-04, Vol.18 (4), p.295-317

2019

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Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

Scientific reports, 2022-08, Vol.12 (1), p.14685-14685, Article 14685

2022

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Cell-free DNA levels associate with COPD exacerbations and mortality

Respiratory research, 2024-01, Vol.25 (1), p.42-42, Article 42

2024

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Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists

American journal of respiratory and critical care medicine, 2018-09, Vol.198 (6), p.739-750

2018

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Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention

Free radical biology & medicine, 2018-08, Vol.124, p.149-162

2018

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Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases

The Journal of pharmacology and experimental therapeutics, 2013-05, Vol.345 (2), p.260

2013

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Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs

Mutagenesis, 2017-05, Vol.32 (3), p.343

2017

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3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

ACS medicinal chemistry letters, 2018-12, Vol.9 (12), p.1164-1169

2018

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4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (16), p.5222-5226

2012

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The Role of IκB Kinase 2, but Not Activation of NF-κB, in the Release of CXCR3 Ligands from IFN-γ-Stimulated Human Bronchial Epithelial Cells

The Journal of immunology (1950), 2007-11, Vol.179 (9), p.6237-6245

2007

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3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2255-2258

2011

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Structural Analysis and Optimization of NK1 Receptor Antagonists through Modulation of Atropisomer Interconversion Properties

Journal of medicinal chemistry, 2004-01, Vol.47 (3), p.519-529

2004

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Design, Synthesis, and SAR of Tachykinin Antagonists: Modulation of Balance in NK1/NK2 Receptor Antagonist Activity

Journal of medicinal chemistry, 2002-08, Vol.45 (18), p.3972-3983

2002

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Design and optimization of cyclized NK1 antagonists with controlled atropisomeric properties

Tetrahedron, 2004-05, Vol.60 (20), p.4337-4347

2004

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Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein−Protein Interaction

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.15949-15972

2021

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Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists

Bioorganic & medicinal chemistry, 2004-05, Vol.12 (10), p.2653-2669

2004

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NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease

American journal of respiratory and critical care medicine, 2023-04, Vol.207 (8), p.998-1011

2023

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Adaptation to hypoxia alters energy metabolism in rat heart

American journal of physiology. Heart and circulatory physiology, 1999-01, Vol.276 (1), p.H71-H80

1999

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Discovery of novel, orally active dual NK1/NK2 antagonists

Bioorganic & medicinal chemistry letters, 2001-10, Vol.11 (20), p.2769-2773

2001

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NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD

American journal of respiratory and critical care medicine, 2023-02, Vol.207 (8), p.998-1011

2023

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Small Molecule Ogg1 Activators Ameliorate mtDNA Oxidation and Promote Cell Health

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists

American journal of respiratory and critical care medicine, 2018-09, Vol.198 (6), p.739-750

2018

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Imaging of Phosphorescence: A Novel Method for Measuring Oxygen Distribution in Perfused Tissue

Science (American Association for the Advancement of Science), 1988-09, Vol.241 (4873), p.1649-1651

1988

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Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors

The Journal of pharmacology and experimental therapeutics, 2001-07, Vol.298 (1), p.307

2001

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Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

Cell-free DNA levels associate with COPD exacerbations and mortality

Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1/NRF2) Protein–Protein Interaction

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists

Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention

Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases

Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

The Role of IκB Kinase 2, but Not Activation of NF-κB, in the Release of CXCR3 Ligands from IFN-γ-Stimulated Human Bronchial Epithelial Cells

3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β

Structural Analysis and Optimization of NK1 Receptor Antagonists through Modulation of Atropisomer Interconversion Properties

Design, Synthesis, and SAR of Tachykinin Antagonists: Modulation of Balance in NK1/NK2 Receptor Antagonist Activity

Design and optimization of cyclized NK1 antagonists with controlled atropisomeric properties

Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein−Protein Interaction

Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists

NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease

Adaptation to hypoxia alters energy metabolism in rat heart

Discovery of novel, orally active dual NK1/NK2 antagonists

NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD

Small Molecule Ogg1 Activators Ameliorate mtDNA Oxidation and Promote Cell Health

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists

Imaging of Phosphorescence: A Novel Method for Measuring Oxygen Distribution in Perfused Tissue

Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors

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