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Preclinical studies of RA475, a guanidine-substituted spirocyclic candidate RPN13/ADRM1 inhibitor for treatment of ovarian cancer

PloS one, 2024-07, Vol.19 (7), p.e0305710

2024

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A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

Cancer cell, 2014-01, Vol.25 (1), p.77-90

2014

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HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy

The Journal of clinical investigation, 2022-05, Vol.132 (9)

2022

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Use of antineoplastic agents in patients with cancer who have HIV/AIDS

The lancet oncology, 2011-09, Vol.12 (9), p.905-912

2011

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A bis-Benzylidine Piperidone Targeting Proteasome Ubiquitin Receptor RPN13/ADRM1 as a Therapy for Cancer

Cancer cell, 2013-12, Vol.24 (6), p.791-805

2013

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Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance

Clinical cancer research, 2011-12, Vol.17 (23), p.7337-7346

2011

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Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model

Clinical cancer research, 2015-08, Vol.21 (15), p.3462-3470

2015

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Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor

PloS one, 2023-06, Vol.18 (6), p.e0285221

2023

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Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

EMBO molecular medicine, 2015-05, Vol.7 (5), p.648-669

2015

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Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice

The Journal of clinical investigation, 2023-07, Vol.133 (13), p.1-21

2023

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Phase II Trial of Imatinib in AIDS-Associated Kaposi's Sarcoma: AIDS Malignancy Consortium Protocol 042

Journal of clinical oncology, 2014-02, Vol.32 (5), p.402-408

2014

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A phase 1 trial of the oral DNA methyltransferase inhibitor CC‐486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors

Cancer, 2019-08, Vol.125 (16), p.2837-2845

2019

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DNA methyltransferase inhibitor exposure–response: Challenges and opportunities

Clinical and translational science, 2023-08, Vol.16 (8), p.1309-1322

2023

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Castration-Dependent Pharmacokinetics of Docetaxel in Patients With Prostate Cancer

Journal of clinical oncology, 2010-10, Vol.28 (30), p.4562-4567

2010

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Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters

Clinical cancer research, 2009-10, Vol.15 (19), p.6062-6069

2009

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A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation

Laboratory investigation, 2011-09, Vol.91 (9), p.1383-1395

2011

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Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms

Cancer research (Chicago, Ill.), 2006-06, Vol.66 (12), p.6361-6369

2006

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A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model

PloS one, 2014-12, Vol.9 (12), p.e114260-e114260

2014

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Ezrin Inhibition Up-regulates Stress Response Gene Expression

The Journal of biological chemistry, 2016-06, Vol.291 (25), p.13257-13270

2016

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TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1α Stabilization

Clinical cancer research, 2010-02, Vol.16 (3), p.857-866

2010

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For HIPEC, synergistic effects of hyperthermia and doxorubicin are optimal when simultaneously combined

International journal of hyperthermia, 2020-01, Vol.37 (1), p.346-348

2020

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The effect of regadenoson-induced transient disruption of the blood–brain barrier on temozolomide delivery to normal rat brain

Journal of neuro-oncology, 2016-02, Vol.126 (3), p.433-439

2016

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Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics

Neuromolecular medicine, 2016-12, Vol.18 (4), p.581-592

2016

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A Novel 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology

Frontiers in oncology, 2022-01, Vol.11, p.790037-790037

2022

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Shorter-course treatment for Mycobacterium ulcerans disease with high-dose rifamycins and clofazimine in a mouse model of Buruli ulcer

PLoS neglected tropical diseases, 2018-08, Vol.12 (8), p.e0006728-e0006728

2018

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Preclinical studies of RA475, a guanidine-substituted spirocyclic candidate RPN13/ADRM1 inhibitor for treatment of ovarian cancer

A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity

HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy

Use of antineoplastic agents in patients with cancer who have HIV/AIDS

A bis-Benzylidine Piperidone Targeting Proteasome Ubiquitin Receptor RPN13/ADRM1 as a Therapy for Cancer

Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance

Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model

Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice

Phase II Trial of Imatinib in AIDS-Associated Kaposi's Sarcoma: AIDS Malignancy Consortium Protocol 042

A phase 1 trial of the oral DNA methyltransferase inhibitor CC‐486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors

DNA methyltransferase inhibitor exposure–response: Challenges and opportunities

Castration-Dependent Pharmacokinetics of Docetaxel in Patients With Prostate Cancer

Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters

A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation

Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms

A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model

Ezrin Inhibition Up-regulates Stress Response Gene Expression

TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1α Stabilization

For HIPEC, synergistic effects of hyperthermia and doxorubicin are optimal when simultaneously combined

The effect of regadenoson-induced transient disruption of the blood–brain barrier on temozolomide delivery to normal rat brain

Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics

A Novel 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology

Shorter-course treatment for Mycobacterium ulcerans disease with high-dose rifamycins and clofazimine in a mouse model of Buruli ulcer

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