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Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)

ChemMedChem, 2016-07, Vol.11 (14), p.1517-1530

2016

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BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models

Molecular cancer therapeutics, 2013-11, Vol.12 (11), p.2319-2330

2013

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Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor

Cancer research (Chicago, Ill.), 2005-05, Vol.65 (9), p.3781-3787

2005

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Constitutively active receptor tyrosine kinases as oncogenes in preclinical models for cancer therapeutics

Molecular cancer therapeutics, 2006-06, Vol.5 (6), p.1571-1576

2006

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Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development

Cancer research (Chicago, Ill.), 2002-05, Vol.62 (9), p.2516-2521

2002

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Temporal Differences in the Activation of Three Classes of Non- Transmembrane Protein Tyrosine Kinases Following B-Cell Antigen Receptor Surface Engagement

Proceedings of the National Academy of Sciences - PNAS, 1994-09, Vol.91 (20), p.9524-9528

1994

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The Src family of tyrosine protein kinases in hemopoietic signal transduction

The FASEB journal, 1992-12, Vol.6 (15), p.3403-3409

1992

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Physical and Functional Interactions between Lyn and p34 Kinases in Irradiated Human B-cell Precursors

The Journal of biological chemistry, 1996-03, Vol.271 (11), p.6389-6397

1996

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Reconstitution of the B Cell Antigen Receptor Signaling Components in COS Cells ()

The Journal of biological chemistry, 1995-11, Vol.270 (45), p.27072-27078

1995

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Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

The Journal of biological chemistry, 1995-05, Vol.270 (19), p.11590-11594

1995

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Abstract B192: Preclinical characterization of BMS-833923 (XL139), a hedgehog (HH) pathway inhibitor in early clinical development

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.B192-B192

2009

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The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling

The EMBO journal, 1996-11, Vol.15 (22), p.6251-6261

1996

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Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase

The Journal of biological chemistry, 1993-11, Vol.268 (32), p.24442-24448

1993

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Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement

The Journal of biological chemistry, 1994-09, Vol.269 (38), p.23642-23647

1994

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Temporal Activation of Nontransmembrane Protein-tyrosine Kinases following Mast Cell Fc∊RI Engagement (∗)

The Journal of biological chemistry, 1995-10, Vol.270 (40), p.23362-23365

1995

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Activation-dependent tyrosine phosphorylation of Fyn-associated proteins in T lymphocytes

The Journal of biological chemistry, 1994-03, Vol.269 (10), p.7792-7800

1994

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Molecular Cloning of Rodent p72

The Journal of biological chemistry, 1995-05, Vol.270 (21), p.12659

1995

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Molecular Cloning of Rodent p72Syk

The Journal of biological chemistry, 1995-05, Vol.270 (21), p.12659-12664

1995

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Temporal Activation of Nontransmembrane Protein-tyrosine Kinases following Mast Cell FcRI Engagement

The Journal of biological chemistry, 1995-10, Vol.270 (40), p.23362

1995

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The FcÎ³RII Receptor Triggers pp125FAK Phosphorylation in Platelets

The Journal of biological chemistry, 1996-07, Vol.271 (27), p.16332

1996

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The FcγRII Receptor Triggers pp125FAK Phosphorylation in Platelets

The Journal of biological chemistry, 1996-07, Vol.271 (27), p.16332-16337

1996

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Isolation of chicken phosphotyrosyl phosphatase cDNA sequences and identification of a brain-specific species related to human PTP zeta

Cellular & molecular biology research, 1993, Vol.39 (3), p.209

1993

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Peripheral-Blood Stem Cells versus Bone Marrow from Unrelated Donors

The New England journal of medicine, 2012-10, Vol.367 (16), p.1487-1496

2012

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Optimization of acquisition parameters for cortical inhomogeneous magnetization transfer (ihMT) imaging using a rapid gradient echo readout

Magnetic resonance in medicine, 2023-11, Vol.90 (5), p.1762-1775

2023

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Deep Brain Nuclei T1 Shortening after Gadobenate Dimeglumine in Children: Influence of Radiation and Chemotherapy

American journal of neuroradiology : AJNR, 2018-01, Vol.39 (1), p.24-30

2018

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Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)

BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models

Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor

Constitutively active receptor tyrosine kinases as oncogenes in preclinical models for cancer therapeutics

Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development

Temporal Differences in the Activation of Three Classes of Non- Transmembrane Protein Tyrosine Kinases Following B-Cell Antigen Receptor Surface Engagement

The Src family of tyrosine protein kinases in hemopoietic signal transduction

Physical and Functional Interactions between Lyn and p34 Kinases in Irradiated Human B-cell Precursors

Reconstitution of the B Cell Antigen Receptor Signaling Components in COS Cells ()

Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation

Abstract B192: Preclinical characterization of BMS-833923 (XL139), a hedgehog (HH) pathway inhibitor in early clinical development

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase

Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement

Temporal Activation of Nontransmembrane Protein-tyrosine Kinases following Mast Cell Fc∊RI Engagement (∗)

Activation-dependent tyrosine phosphorylation of Fyn-associated proteins in T lymphocytes

Molecular Cloning of Rodent p72

Molecular Cloning of Rodent p72Syk

Temporal Activation of Nontransmembrane Protein-tyrosine Kinases following Mast Cell FcRI Engagement

The FcÎ³RII Receptor Triggers pp125FAK Phosphorylation in Platelets

The FcγRII Receptor Triggers pp125FAK Phosphorylation in Platelets

Isolation of chicken phosphotyrosyl phosphatase cDNA sequences and identification of a brain-specific species related to human PTP zeta

Peripheral-Blood Stem Cells versus Bone Marrow from Unrelated Donors

Optimization of acquisition parameters for cortical inhomogeneous magnetization transfer (ihMT) imaging using a rapid gradient echo readout

Deep Brain Nuclei T1 Shortening after Gadobenate Dimeglumine in Children: Influence of Radiation and Chemotherapy

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