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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

Human molecular genetics, 2011-11, Vol.20 (21), p.4209-4223

2011

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Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

Journal of neurochemistry, 2009-11, Vol.111 (3), p.703-715

2009

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High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain

PloS one, 2012-05, Vol.7 (5), p.e36581-e36581

2012

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Chemical genetic approach identifies microtubule affinity‐regulating kinase 1 as a leucine‐rich repeat kinase 2 substrate

The FASEB journal, 2015-07, Vol.29 (7), p.2980-2992

2015

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Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins

The Journal of biological chemistry, 2004-12, Vol.279 (49), p.50790-50798

2004

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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

Human molecular genetics, 2011-11, Vol.20 (21), p.4209-4223

2011

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The Cellular Protein Level of Parkin Is Regulated by Its Ubiquitin-like Domain

The Journal of biological chemistry, 2003-05, Vol.278 (18), p.16054-16058

2003

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SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production

Nature cell biology, 2006-08, Vol.8 (8), p.843-848

2006

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Leucine-rich repeat kinase 2 induces α-synuclein expression via the extracellular signal-regulated kinase pathway

Cellular signalling, 2010-05, Vol.22 (5), p.821-827

2010

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Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4085-4090

2013

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Protein isoaspartyl methyltransferase protects from Bax-induced apoptosis

Gene, 1999-11, Vol.240 (2), p.333-341

1999

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Leucine-Rich Repeat Kinase 2 Is Associated With the Endoplasmic Reticulum in Dopaminergic Neurons and Accumulates in the Core of Lewy Bodies in Parkinson Disease

Journal of neuropathology and experimental neurology, 2010-09, Vol.69 (9), p.959-972

2010

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Allosteric interactions between GB1 and GB2 subunits are required for optimal GABAB receptor function

The EMBO journal, 2001-05, Vol.20 (9), p.2152-2159

2001

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C-Terminal Interaction Is Essential for Surface Trafficking But Not for Heteromeric Assembly of GABAB Receptors

The Journal of neuroscience, 2001-02, Vol.21 (4), p.1189-1202

2001

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Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with γ-Secretase Inhibitors

The Journal of biological chemistry, 2003-05, Vol.278 (19), p.16528-16533

2003

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Transphosphorylation of the Neurotrophin Trk Receptors (∗)

The Journal of biological chemistry, 1996-03, Vol.271 (10), p.5812-5818

1996

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Part I: Parkin-associated proteins and Parkinson’s disease

Neuropharmacology, 2003-07, Vol.45 (1), p.1-13

2003

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cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily

Biochemistry (Easton), 1987-10, Vol.26 (20), p.6407-6410

1987

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Characterization of the heparin-binding site of glia-derived nexin/protease nexin-1

Biochemistry (Easton), 1992-04, Vol.31 (13), p.3542-3549

1992

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Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals

European journal of pharmacology, 2006-07, Vol.540 (1), p.10-17

2006

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Leucine-rich repeat kinase 2 induces a-synuclein expression via the extracellular signal-regulated kinase pathway

Cellular signalling, 2010-05, Vol.22 (5), p.821-827

2010

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A Novel Site on the Gα-protein That Recognizes Heptahelical Receptors

The Journal of biological chemistry, 2001-02, Vol.276 (5), p.3262-3269

2001

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Poxvirus-derived cytokine response modifier A (CrmA) does not protect against focal cerebral ischemia in mice

Brain research, 2007-12, Vol.1185, p.293-300

2007

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SPPL2a and SPPL2b promote intramembrane proteolysis of TNF[alpha] in activated dendritic cells to trigger IL-12 production

Nature cell biology, 2006-08, Vol.8 (8), p.843-848

2006

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SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

Nature cell biology, 2006-08, Vol.8 (8), p.843-848

2006

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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain

Chemical genetic approach identifies microtubule affinity‐regulating kinase 1 as a leucine‐rich repeat kinase 2 substrate

Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

The Cellular Protein Level of Parkin Is Regulated by Its Ubiquitin-like Domain

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production

Leucine-rich repeat kinase 2 induces α-synuclein expression via the extracellular signal-regulated kinase pathway

Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2

Protein isoaspartyl methyltransferase protects from Bax-induced apoptosis

Leucine-Rich Repeat Kinase 2 Is Associated With the Endoplasmic Reticulum in Dopaminergic Neurons and Accumulates in the Core of Lewy Bodies in Parkinson Disease

Allosteric interactions between GB1 and GB2 subunits are required for optimal GABAB receptor function

C-Terminal Interaction Is Essential for Surface Trafficking But Not for Heteromeric Assembly of GABAB Receptors

Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with γ-Secretase Inhibitors

Transphosphorylation of the Neurotrophin Trk Receptors (∗)

Part I: Parkin-associated proteins and Parkinson’s disease

cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily

Characterization of the heparin-binding site of glia-derived nexin/protease nexin-1

Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals

Leucine-rich repeat kinase 2 induces a-synuclein expression via the extracellular signal-regulated kinase pathway

A Novel Site on the Gα-protein That Recognizes Heptahelical Receptors

Poxvirus-derived cytokine response modifier A (CrmA) does not protect against focal cerebral ischemia in mice

SPPL2a and SPPL2b promote intramembrane proteolysis of TNF[alpha] in activated dendritic cells to trigger IL-12 production

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

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