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The role of nonrandomized trials in the evaluation of oncology drugs

Clinical pharmacology and therapeutics, 2015-05, Vol.97 (5), p.502-507

2015

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Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX-4) as second-line therapy in metastatic colorectal cancer: a randomized phase III noninferiority study

Annals of oncology, 2008-10, Vol.19 (10), p.1720-1726

2008

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Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

Journal of clinical oncology, 1997-06, Vol.15 (6), p.2403-2413

1997

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Multicenter phase II trial of adjuvant therapy for resected pancreatic cancer using cisplatin, 5-fluorouracil, and interferon-alfa-2b–based chemoradiation: ACOSOG Trial Z05031

Annals of oncology, 2011-02, Vol.22 (2), p.348-354

2011

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Matrix Metalloproteinases: Biologic Activity and Clinical Implications

Journal of clinical oncology, 2000-03, Vol.18 (5), p.1135-1149

2000

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Topoisomerase I inhibitors: Review and update

Annals of oncology, 1997-09, Vol.8 (9), p.837-855

ROTHENBERG, M. L

1997

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Mortality Associated With Irinotecan Plus Bolus Fluorouracil/Leucovorin: Summary Findings of an Independent Panel

Journal of clinical oncology, 2001-09, Vol.19 (18), p.3801-3807

2001

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A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer

Annals of oncology, 1996-04, Vol.7 (4), p.347-353

1996

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Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer

Journal of clinical oncology, 1996-04, Vol.14 (4), p.1128-1135

1996

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Tumor angiogenesis in advanced stage ovarian carcinoma

The American journal of pathology, 1995-07, Vol.147 (1), p.33-41

1995

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An Investigational new drug treatment program for patients with gemcitabine : Results for over 3000 patients with pancreatic carcinoma

Cancer, 1999-03, Vol.85 (6), p.1261-1268

1999

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Pragmatic randomized clinical trials: a proposal to enhance evaluation of new cancer therapies with early signs of exceptional activity

Annals of oncology, 2016-07, Vol.27 (7), p.1342-1348

2016

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A phase II study of irinotecan with 5-fluorouracil and leucovorin in patients with previously untreated gastric adenocarcinoma

Annals of oncology, 2001-11, Vol.12 (11), p.1575-1580

2001

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Phase I and pharmacokinetic trial of weekly CPT-11

Journal of clinical oncology, 1993-11, Vol.11 (11), p.2194-2204

1993

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Efficacy and toxicity of irinotecan in patients with colorectal cancer

Seminars in oncology, 1998-10, Vol.25 (5 Suppl 11), p.39

Rothenberg, M L

1998

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Phase I trial of oral MAC-321 in subjects with advanced malignant solid tumors

Cancer chemotherapy and pharmacology, 2007-07, Vol.60 (2), p.203-209

2007

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Phase I dose-finding and pharmacokinetic trial of irinotecan (CPT-11) administered every two weeks

Annals of oncology, 2001-11, Vol.12 (11), p.1631-1641

2001

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Incidence and evolution of oxaliplatin-induced peripheral sensory neuropathy in diabetic patients with colorectal cancer: a pooled analysis of three phase III studies

Annals of oncology, 2010-04, Vol.21 (4), p.754-758

2010

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Phase II trial of 5-fluorouracil plus eniluracil in patients with advanced pancreatic cancer: a Southwest Oncology Group study

Annals of oncology, 2002-10, Vol.13 (10), p.1576-1582

2002

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Phase I and Pharmacokinetic Trial of Oral Irinotecan Administered Daily for 5 Days Every 3 Weeks in Patients With Solid Tumors

Journal of clinical oncology, 1999-02, Vol.17 (2), p.685-696

1999

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Irinotecan (CPT‐11): Recent Developments and Future Directions–Colorectal Cancer and Beyond

The oncologist (Dayton, Ohio), 2001-02, Vol.6 (1), p.66-80

Rothenberg, Mace L.

2001

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Phase I trial of paclitaxel and gemcitabine administered every two weeks in patients with refractory solid tumors

Annals of oncology, 1998-07, Vol.9 (7), p.733-738

1998

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CPT-11: an original spectrum of clinical activity

Seminars in oncology, 1996-02, Vol.23 (1 Suppl 3), p.21

Rothenberg, M L

1996

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Improving the evaluation of new cancer treatments: challenges and opportunities

Nature reviews. Cancer, 2003-04, Vol.3 (4), p.303-309

2003

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A rationale for expanding the endpoints for clinical trials in advanced pancreatic carcinoma

Cancer, 1996-08, Vol.78 (3), p.627-632

1996

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The role of nonrandomized trials in the evaluation of oncology drugs

Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX-4) as second-line therapy in metastatic colorectal cancer: a randomized phase III noninferiority study

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial

Multicenter phase II trial of adjuvant therapy for resected pancreatic cancer using cisplatin, 5-fluorouracil, and interferon-alfa-2b–based chemoradiation: ACOSOG Trial Z05031

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

Topoisomerase I inhibitors: Review and update

Mortality Associated With Irinotecan Plus Bolus Fluorouracil/Leucovorin: Summary Findings of an Independent Panel

A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer

Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer

Tumor angiogenesis in advanced stage ovarian carcinoma

An Investigational new drug treatment program for patients with gemcitabine : Results for over 3000 patients with pancreatic carcinoma

Pragmatic randomized clinical trials: a proposal to enhance evaluation of new cancer therapies with early signs of exceptional activity

A phase II study of irinotecan with 5-fluorouracil and leucovorin in patients with previously untreated gastric adenocarcinoma

Phase I and pharmacokinetic trial of weekly CPT-11

Efficacy and toxicity of irinotecan in patients with colorectal cancer

Phase I trial of oral MAC-321 in subjects with advanced malignant solid tumors

Phase I dose-finding and pharmacokinetic trial of irinotecan (CPT-11) administered every two weeks

Incidence and evolution of oxaliplatin-induced peripheral sensory neuropathy in diabetic patients with colorectal cancer: a pooled analysis of three phase III studies

Phase II trial of 5-fluorouracil plus eniluracil in patients with advanced pancreatic cancer: a Southwest Oncology Group study

Phase I and Pharmacokinetic Trial of Oral Irinotecan Administered Daily for 5 Days Every 3 Weeks in Patients With Solid Tumors

Irinotecan (CPT‐11): Recent Developments and Future Directions–Colorectal Cancer and Beyond

Phase I trial of paclitaxel and gemcitabine administered every two weeks in patients with refractory solid tumors

CPT-11: an original spectrum of clinical activity

Improving the evaluation of new cancer treatments: challenges and opportunities

A rationale for expanding the endpoints for clinical trials in advanced pancreatic carcinoma

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