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Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

Neuron (Cambridge, Mass.), 2016-09, Vol.91 (6), p.1244-1252

2016

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Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (4), p.1196-1201

2015

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M 1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons

Neuropharmacology, 2017-05, Vol.118, p.209-222

2017

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Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (45), p.14078-14083

2015

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Tumor therapy by targeting extracellular hydroxyapatite using novel drugs: A paradigm shift

Cancer medicine (Malden, MA), 2024-02, Vol.13 (3), p.e6812-n/a

2024

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Temporal Effects of Topical Morphine Application on Cutaneous Wound Healing

Anesthesiology (Philadelphia), 2008-07, Vol.109 (1), p.130-136

2008

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Morphine-induced early delays in wound closure: Involvement of sensory neuropeptides and modification of neurokinin receptor expression

Biochemical pharmacology, 2009-06, Vol.77 (11), p.1747-1755

2009

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A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes

JCI insight, 2021-02, Vol.6 (4)

2021

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Delay of cutaneous wound closure by morphine via local blockade of peripheral tachykinin release

Biochemical pharmacology, 2007-09, Vol.74 (5), p.752-757

2007

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M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

Neuropsychopharmacology (New York, N.Y.), 2018-07, Vol.43 (8), p.1763-1771

2018

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M 1 -positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

Neuropsychopharmacology (New York, N.Y.), 2018-07, Vol.43 (8), p.1763

2018

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mGlu1 and mGlu5 modulate distinct excitatory inputs to the nucleus accumbens shell

Neuropsychopharmacology (New York, N.Y.), 2018-09, Vol.43 (10), p.2075-2082

2018

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Development of a Selective and High Affinity Radioligand, [ 3 H]VU6013720, for the M 4 Muscarinic Receptor

Molecular pharmacology, 2023-11, Vol.104 (5), p.195-202

2023

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M1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons

Neuropharmacology, 2017-05, Vol.118, p.209-222

2017

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Mutual activation of glutamatergic mGlu4 and muscarinic M4 receptors reverses schizophrenia-related changes in rodents

Psychopharmacology, 2018-10, Vol.235 (10), p.2897-2913

2018

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Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M 4 Muscarinic Receptor

Neuron (Cambridge, Mass.), 2017-12, Vol.96 (6), p.1358

2017

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An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia

Neuropsychopharmacology (New York, N.Y.), 2016-07, Vol.41 (8), p.2052-2061

2016

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Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M4 Muscarinic Receptor

Neuron (Cambridge, Mass.), 2017-12, Vol.96 (6), p.1358-1372.e4

2017

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Hyperactive Striatal Dopamine Signaling Observed in Huntington's Disease Mouse Models Prior to Motor Symptom Onset Can be Attenuated via Activation of M 4 Receptors

The FASEB journal, 2022-05, Vol.36 Suppl 1 (S1)

2022

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CB2 Receptor Potentiation Mediates Antipsychotic‐like Efficacy in Mice

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome

Human molecular genetics, 2016-05, Vol.25 (10), p.1990-2004

2016

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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

Molecular pharmacology, 2010-12, Vol.78 (6), p.1105-1123

2010

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Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

Biological psychiatry (1969), 2013-03, Vol.73 (6), p.501-509

2013

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Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia

Neuropsychiatric disease and treatment, 2014-01, Vol.10, p.183-191

2014

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Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor

Bioorganic & medicinal chemistry letters, 2022-01, Vol.56, p.128479-128479, Article 128479

2022

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Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction

M 1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons

Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

Tumor therapy by targeting extracellular hydroxyapatite using novel drugs: A paradigm shift

Temporal Effects of Topical Morphine Application on Cutaneous Wound Healing

Morphine-induced early delays in wound closure: Involvement of sensory neuropeptides and modification of neurokinin receptor expression

A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes

Delay of cutaneous wound closure by morphine via local blockade of peripheral tachykinin release

M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

M 1 -positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

mGlu1 and mGlu5 modulate distinct excitatory inputs to the nucleus accumbens shell

Development of a Selective and High Affinity Radioligand, [ 3 H]VU6013720, for the M 4 Muscarinic Receptor

M1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons

Mutual activation of glutamatergic mGlu4 and muscarinic M4 receptors reverses schizophrenia-related changes in rodents

Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M 4 Muscarinic Receptor

An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia

Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M4 Muscarinic Receptor

Hyperactive Striatal Dopamine Signaling Observed in Huntington's Disease Mouse Models Prior to Motor Symptom Onset Can be Attenuated via Activation of M 4 Receptors

CB2 Receptor Potentiation Mediates Antipsychotic‐like Efficacy in Mice

mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia

Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor

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