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Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutical targets

Current medicinal chemistry, 2011-08, Vol.18 (24), p.3662-3674

2011

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Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy

Neuropharmacology, 2018-03, Vol.131, p.403-413

2018

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Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (18), p.5071-5074

2008

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Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (5), p.1936-1939

2012

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WEB-2086 and WEB-2170 trigger apoptosis in both ATRA-sensitive and -resistant promyelocytic leukemia cells and greatly enhance ATRA differentiation potential

Leukemia, 2005-03, Vol.19 (3), p.390-395

2005

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Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring

European journal of medicinal chemistry, 2013-08, Vol.66, p.56-68

2013

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AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram)

Naunyn-Schmiedeberg's archives of pharmacology, 2003-12, Vol.368 (6), p.538-545

2003

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Design, Synthesis, and in Vitro Activity of Catamphiphilic Reverters of Multidrug Resistance: Discovery of a Selective, Highly Efficacious Chemosensitizer with Potency in the Nanomolar Range

Journal of medicinal chemistry, 1999-05, Vol.42 (10), p.1687-1697

1999

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The new low‐toxic histone deacetylase inhibitor S‐(2) induces apoptosis in various acute myeloid leukaemia cells

Journal of cellular and molecular medicine, 2012-08, Vol.16 (8), p.1758-1765

2012

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Molecular Simplification of 1,4-Diazabicyclo[4.3.0]nonan-9-ones Gives Piperazine Derivatives That Maintain High Nootropic Activity

Journal of medicinal chemistry, 2000-11, Vol.43 (23), p.4499-4507

2000

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Analgesic effects of myrrh

Nature (London), 1996-01, Vol.379 (6560), p.29-29

1996

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Structure–activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists

Bioorganic & medicinal chemistry, 2001-05, Vol.9 (5), p.1165-1174

2001

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Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs

Current pharmaceutical design, 2002, Vol.8 (2), p.125-138

2002

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Exploratory Chemistry toward the Identification of a New Class of Multidrug Resistance Reverters Inspired by Pervilleine and Verapamil Models

Journal of medicinal chemistry, 2005-11, Vol.48 (23), p.7426-7436

2005

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Synthesis and binding properties of photoactivable biotin-conjugated verapamil derivatives for the study of P-170 glycoprotein

Bioorganic & medicinal chemistry, 1999-09, Vol.7 (9), p.1873-1880

1999

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Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP)

Journal of medicinal chemistry, 2001-11, Vol.44 (23), p.3946-3955

2001

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HCN Channels Modulators: The Need for Selectivity

Current topics in medicinal chemistry, 2016-07, Vol.16 (16), p.1764-1791

2016

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Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity

European journal of medicinal chemistry, 1997-07, Vol.32 (7), p.595-605

1997

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Design, Synthesis, and Preliminary Pharmacological Evaluation of 1,4-Diazabicyclo[4.3.0]nonan-9-ones as a New Class of Highly Potent Nootropic Agents

Journal of medicinal chemistry, 2000-05, Vol.43 (10), p.1969-1974

2000

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Structural dependence of the allosteric interaction of semi-rigid verapamil analogues with dihydropyridine-binding in kitten heart

European journal of pharmacology, 1995-11, Vol.291 (3), p.255-264

1995

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DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer

Naunyn-Schmiedeberg's archives of pharmacology, 2002-06, Vol.365 (6), p.419-426

2002

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The medicinal chemistry of Alzheimer's and Alzheimer-like diseases with emphasis on the cholinergic hypothesis

Farmaco (Società chimica italiana : 1989), 1995-07, Vol.50 (7-8), p.489

1995

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Structure−Activity Relationships Studies in a Series of N,N-Bis(alkanol)amine Aryl Esters as P-Glycoprotein (Pgp) Dependent Multidrug Resistance (MDR) Inhibitors

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1755-1762

2010

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Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors

Metabolites, 2018-05, Vol.8 (2), p.36

2018

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Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: Further restriction of molecular flexibility maintains high potency and efficacy

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.106-109

2011

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Selective pharmacological inhibition of the pacemaker channel isoforms (HCN1-4) as new possible therapeutical targets

Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy

Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents

Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs

WEB-2086 and WEB-2170 trigger apoptosis in both ATRA-sensitive and -resistant promyelocytic leukemia cells and greatly enhance ATRA differentiation potential

Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring

AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram)

Design, Synthesis, and in Vitro Activity of Catamphiphilic Reverters of Multidrug Resistance: Discovery of a Selective, Highly Efficacious Chemosensitizer with Potency in the Nanomolar Range

The new low‐toxic histone deacetylase inhibitor S‐(2) induces apoptosis in various acute myeloid leukaemia cells

Molecular Simplification of 1,4-Diazabicyclo[4.3.0]nonan-9-ones Gives Piperazine Derivatives That Maintain High Nootropic Activity

Analgesic effects of myrrh

Structure–activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists

Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs

Exploratory Chemistry toward the Identification of a New Class of Multidrug Resistance Reverters Inspired by Pervilleine and Verapamil Models

Synthesis and binding properties of photoactivable biotin-conjugated verapamil derivatives for the study of P-170 glycoprotein

Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP)

HCN Channels Modulators: The Need for Selectivity

Differential analgesic activity of the enantiomers of atropine derivatives does not correlate with their muscarinic subtype selectivity

Design, Synthesis, and Preliminary Pharmacological Evaluation of 1,4-Diazabicyclo[4.3.0]nonan-9-ones as a New Class of Highly Potent Nootropic Agents

Structural dependence of the allosteric interaction of semi-rigid verapamil analogues with dihydropyridine-binding in kitten heart

DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer

The medicinal chemistry of Alzheimer's and Alzheimer-like diseases with emphasis on the cholinergic hypothesis

Structure−Activity Relationships Studies in a Series of N,N-Bis(alkanol)amine Aryl Esters as P-Glycoprotein (Pgp) Dependent Multidrug Resistance (MDR) Inhibitors

Amino Acids as Building Blocks for Carbonic Anhydrase Inhibitors

Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: Further restriction of molecular flexibility maintains high potency and efficacy

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