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Bacterial fatty acid metabolism in modern antibiotic discovery

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2017-11, Vol.1862 (11), p.1300-1309

2017

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How Bacterial Pathogens Eat Host Lipids: Implications for the Development of Fatty Acid Synthesis Therapeutics

The Journal of biological chemistry, 2015-03, Vol.290 (10), p.5940-5946

2015

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Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

Current opinion in microbiology, 2011-10, Vol.14 (5), p.544-549

2011

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Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation

The Journal of biological chemistry, 2012-04, Vol.287 (18), p.14615-14620

2012

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Human pantothenate kinase 4 is a pseudo‐pantothenate kinase

Protein science, 2019-06, Vol.28 (6), p.1031-1047

2019

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A therapeutic approach to pantothenate kinase associated neurodegeneration

Nature communications, 2018-10, Vol.9 (1), p.4399-15, Article 4399

2018

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RhlA Converts β-Hydroxyacyl-Acyl Carrier Protein Intermediates in Fatty Acid Synthesis to the β-Hydroxydecanoyl-β-Hydroxydecanoate Component of Rhamnolipids in Pseudomonas aeruginosa

Journal of Bacteriology, 2008-05, Vol.190 (9), p.3147-3154

2008

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Membrane Disruption by Antimicrobial Fatty Acids Releases Low-Molecular-Weight Proteins from Staphylococcus aureus

Journal of Bacteriology, 2012-10, Vol.194 (19), p.5294-5304

2012

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Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (37), p.15378-15383

2011

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Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (29), p.10532-10537

2014

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Domain architecture and catalysis of the Staphylococcus aureus fatty acid kinase

The Journal of biological chemistry, 2022-06, Vol.298 (6), p.101993, Article 101993

2022

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Pyruvate Oxidase as a Critical Link between Metabolism and Capsule Biosynthesis in Streptococcus pneumoniae

PLoS pathogens, 2016-10, Vol.12 (10), p.e1005951

2016

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Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state

PloS one, 2010-06, Vol.5 (6), p.e11107-e11107

2010

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Incorporation of extracellular fatty acids by a fatty acid kinase‐dependent pathway in Staphylococcus aureus

Molecular microbiology, 2014-04, Vol.92 (2), p.234-245

2014

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A fatty acid-binding protein of Streptococcus pneumoniae facilitates the acquisition of host polyunsaturated fatty acids

The Journal of biological chemistry, 2019-11, Vol.294 (44), p.16416-16428

2019

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A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer

Nature structural & molecular biology, 2017-08, Vol.24 (8), p.666-671

2017

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Thematic Review Series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis

Journal of lipid research, 2008-09, Vol.49 (9), p.1867-1874

2008

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Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1

Cell host & microbe, 2012-09, Vol.12 (3), p.313-323

2012

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Inhibiting Bacterial Fatty Acid Synthesis

The Journal of biological chemistry, 2006-06, Vol.281 (26), p.17541-17544

2006

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A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance

Nature communications, 2022-06, Vol.13 (1), p.3165-3165, Article 3165

2022

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The structural biology of type II fatty acid biosynthesis

Annual review of biochemistry, 2005-01, Vol.74 (1), p.791-831

2005

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The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate Synthase

Frontiers in microbiology, 2018-07, Vol.9, p.1369-1369

2018

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Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis

The Journal of biological chemistry, 2015-07, Vol.290 (31), p.18874-18888

2015

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Acyl-chain selectivity and physiological roles of Staphylococcus aureus fatty acid–binding proteins

The Journal of biological chemistry, 2019-01, Vol.294 (1), p.38-49

2019

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Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis

Frontiers in microbiology, 2018-09, Vol.9, p.2291-2291

2018

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Bacterial fatty acid metabolism in modern antibiotic discovery

How Bacterial Pathogens Eat Host Lipids: Implications for the Development of Fatty Acid Synthesis Therapeutics

Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation

Human pantothenate kinase 4 is a pseudo‐pantothenate kinase

A therapeutic approach to pantothenate kinase associated neurodegeneration

RhlA Converts β-Hydroxyacyl-Acyl Carrier Protein Intermediates in Fatty Acid Synthesis to the β-Hydroxydecanoyl-β-Hydroxydecanoate Component of Rhamnolipids in Pseudomonas aeruginosa

Membrane Disruption by Antimicrobial Fatty Acids Releases Low-Molecular-Weight Proteins from Staphylococcus aureus

Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors

Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus

Domain architecture and catalysis of the Staphylococcus aureus fatty acid kinase

Pyruvate Oxidase as a Critical Link between Metabolism and Capsule Biosynthesis in Streptococcus pneumoniae

Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state

Incorporation of extracellular fatty acids by a fatty acid kinase‐dependent pathway in Staphylococcus aureus

A fatty acid-binding protein of Streptococcus pneumoniae facilitates the acquisition of host polyunsaturated fatty acids

A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer

Thematic Review Series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis

Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1

Inhibiting Bacterial Fatty Acid Synthesis

A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance

The structural biology of type II fatty acid biosynthesis

The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate Synthase

Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis

Acyl-chain selectivity and physiological roles of Staphylococcus aureus fatty acid–binding proteins

Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis

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