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Bruton's Tyrosine Kinase (BTK) Inhibitors and Autoimmune Diseases: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures

Frontiers in immunology, 2021-11, Vol.12, p.662223-662223

2021

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Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity

The Journal of immunology (1950), 2017-10, Vol.199 (7), p.2388-2407

2017

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Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study

Rheumatology and therapy., 2020-03, Vol.7 (1), p.101-119

2020

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Teriflunomide attenuates immunopathological changes in the dark agouti rat model of experimental autoimmune encephalomyelitis

Frontiers in neurology, 2013-01, Vol.4, p.169-169

2013

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P2X7 receptor modulation of β-amyloid- and LPS-induced cytokine secretion from human macrophages and microglia

Journal of neuroimmunology, 2004-02, Vol.147 (1), p.56-61

2004

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IL-4, IL-10 and IL-13 modulate Aβ(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line

Journal of neuroimmunology, 2001-02, Vol.113 (1), p.49-62

2001

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Neurodegenerative disease and the neuroimmune axis (Alzheimer's and Parkinson's disease, and viral infections)

Journal of neuroimmunology, 2004-02, Vol.147 (1), p.43-49

2004

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Amyloid‐β peptide fragments p3 and p4 induce pro‐inflammatory cytokine and chemokine production in vitro and in vivo

Journal of neurochemistry, 2001-04, Vol.77 (1), p.304-317

2001

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Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex

Brain research. Molecular brain research., 1998-03, Vol.55 (1), p.35-44

1998

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Interleukin-6 mRNA expression by cortical neurons in culture: Evidence for neuronal sources of interleukin-6 production in the brain

Journal of neuroimmunology, 1995-12, Vol.63 (2), p.113-123

1995

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First‐in‐Human (FIH), Single‐ and Multiple‐Ascending‐Dose (SAD/MAD) studies in healthy subjects of E2511, a novel tropomyosin receptor kinase a (TrkA) positive allosteric modulator (PAM)

Alzheimer's & dementia, 2023-06, Vol.19 (S7), p.n/a

2023

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Glial Modulating and Neurotrophic Properties of Propentofylline and Its Application to Alzheimer's Disease and Vascular Dementia

Annals of the New York Academy of Sciences, 2000-04, Vol.903 (1), p.529-534

RINGHEIM, GARTH E.

2000

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Tyrosine phosphorylation of inducible nitric oxide synthase: implications for potential post-translational regulation

Biochemical journal, 1996-03, Vol.314 ( Pt 3) (3), p.889-894

1996

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Mitogenic effects of interleukin-5 on microglia

Neuroscience letters, 1995-12, Vol.201 (2), p.131-134

Ringheim, Garth E.

1995

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Amyloid-beta peptide fragments p3 and p4 induce pro-inflammatory cytokine and chemokine production in vitro and in vivo

Journal of neurochemistry, 2001-04, Vol.77 (1), p.304-317

2001

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ADDITIVE EFFECTS OF BASIC FIBROBLAST GROWTH FACTOR AND PHORBOL ESTER ON β-AMYLOID PRECURSOR PROTEIN EXPRESSION AND SECRETION

Neurochemistry international, 1997-04, Vol.30 (4), p.475-481

1997

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Brain inflammation, cholesterol, and glutamate as interconnected participants in the pathology of Alzheimer's disease

Current pharmaceutical design, 2006-02, Vol.12 (6), p.719-738

2006

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IL-10 and glucocorticoids inhibit Aβ(1–42)- and lipopolysaccharide-induced pro-inflammatory cytokine and chemokine induction in the central nervous system

Journal of Alzheimer's disease, 2003-01, Vol.5 (2), p.105-117

2003

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CYCLIC AMP POTENTIATION OF CYTOKINE-INDUCED NITRIC OXIDE SYNTHASE ACTIVITY IN A MURINE ASTROCYTE CELL LINE

Neurochemistry international, 1997-04, Vol.30 (4), p.483-489

1997

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O3-04-03 Aβ induces microglial cystine-glutamate transporter (XCT) gene expression and glutamate release that is suppressed by anti-inflammatory cytokines

Neurobiology of aging, 2004-07, Vol.25, p.S59-S60

2004

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IL-10 and glucocorticoids inhibit Abeta(1-42)- and lipopolysaccharide-induced pro-inflammatory cytokine and chemokine induction in the central nervous system

Journal of Alzheimer's disease, 2003-04, Vol.5 (2), p.105

2003

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Particulate and Soluble Forms of the Inducible Nitric Oxide Synthase Are Distinguishable at the Amino Terminus in Raw 264.7 Macrophage Cells

Biochemical and biophysical research communications, 1995-05, Vol.210 (3), p.711-716

1995

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Transcriptional Inhibition of the Beta-Amyloid Precursor Protein by Interferon-Gamma

Biochemical and biophysical research communications, 1996-07, Vol.224 (1), p.246-251

1996

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Dissecting the domain structure of the regulatory subunit of cAMP-dependent protein kinase I and elucidating the role of MgATP

The Journal of biological chemistry, 1990-03, Vol.265 (9), p.4800-4808

1990

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Effects of cAMP-binding site mutations on intradomain cross-communication in the regulatory subunit of cAMP-dependent protein kinase I

The Journal of biological chemistry, 1990-11, Vol.265 (32), p.19472-19478

1990

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Bruton's Tyrosine Kinase (BTK) Inhibitors and Autoimmune Diseases: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures

Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity

Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study

Teriflunomide attenuates immunopathological changes in the dark agouti rat model of experimental autoimmune encephalomyelitis

P2X7 receptor modulation of β-amyloid- and LPS-induced cytokine secretion from human macrophages and microglia

IL-4, IL-10 and IL-13 modulate Aβ(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line

Neurodegenerative disease and the neuroimmune axis (Alzheimer's and Parkinson's disease, and viral infections)

Amyloid‐β peptide fragments p3 and p4 induce pro‐inflammatory cytokine and chemokine production in vitro and in vivo

Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex

Interleukin-6 mRNA expression by cortical neurons in culture: Evidence for neuronal sources of interleukin-6 production in the brain

First‐in‐Human (FIH), Single‐ and Multiple‐Ascending‐Dose (SAD/MAD) studies in healthy subjects of E2511, a novel tropomyosin receptor kinase a (TrkA) positive allosteric modulator (PAM)

Glial Modulating and Neurotrophic Properties of Propentofylline and Its Application to Alzheimer's Disease and Vascular Dementia

Tyrosine phosphorylation of inducible nitric oxide synthase: implications for potential post-translational regulation

Mitogenic effects of interleukin-5 on microglia

Amyloid-beta peptide fragments p3 and p4 induce pro-inflammatory cytokine and chemokine production in vitro and in vivo

ADDITIVE EFFECTS OF BASIC FIBROBLAST GROWTH FACTOR AND PHORBOL ESTER ON β-AMYLOID PRECURSOR PROTEIN EXPRESSION AND SECRETION

Brain inflammation, cholesterol, and glutamate as interconnected participants in the pathology of Alzheimer's disease

IL-10 and glucocorticoids inhibit Aβ(1–42)- and lipopolysaccharide-induced pro-inflammatory cytokine and chemokine induction in the central nervous system

CYCLIC AMP POTENTIATION OF CYTOKINE-INDUCED NITRIC OXIDE SYNTHASE ACTIVITY IN A MURINE ASTROCYTE CELL LINE

O3-04-03 Aβ induces microglial cystine-glutamate transporter (XCT) gene expression and glutamate release that is suppressed by anti-inflammatory cytokines

IL-10 and glucocorticoids inhibit Abeta(1-42)- and lipopolysaccharide-induced pro-inflammatory cytokine and chemokine induction in the central nervous system

Particulate and Soluble Forms of the Inducible Nitric Oxide Synthase Are Distinguishable at the Amino Terminus in Raw 264.7 Macrophage Cells

Transcriptional Inhibition of the Beta-Amyloid Precursor Protein by Interferon-Gamma

Dissecting the domain structure of the regulatory subunit of cAMP-dependent protein kinase I and elucidating the role of MgATP

Effects of cAMP-binding site mutations on intradomain cross-communication in the regulatory subunit of cAMP-dependent protein kinase I

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