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Improved fluorogenic histone deacetylase assay for high-throughput-screening applications

Analytical biochemistry, 2003-10, Vol.321 (2), p.202-208

2003

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Factors affecting the substrate specificity of histone deacetylases

Biochemical and biophysical research communications, 2007-06, Vol.357 (2), p.439-445

2007

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Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases

Journal of biotechnology, 2006-06, Vol.124 (1), p.258-270

2006

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Histone deacetylases--an important class of cellular regulators with a variety of functions

Applied microbiology and biotechnology, 2007-06, Vol.75 (3), p.487-497

2007

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Histone deacetylase inhibitor assay based on fluorescence resonance energy transfer

Analytical biochemistry, 2007-03, Vol.362 (1), p.136-141

2007

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A New Amidohydrolase from Bordetella or Alcaligenes Strain FB188 with Similarities to Histone Deacetylases

Journal of Bacteriology, 2004-04, Vol.186 (8), p.2328-2339

2004

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Thrombin Inhibitors Identified by Computer-Assisted Multiparameter Design

Proceedings of the National Academy of Sciences - PNAS, 2005-06, Vol.102 (24), p.8597-8602

2005

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Histone deacetylase inhibitors--turning epigenic mechanisms of gene regulation into tools of therapeutic intervention in malignant and other diseases

Applied microbiology and biotechnology, 2007-06, Vol.75 (3), p.499-514

2007

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Members of the histone deacetylase superfamily differ in substrate specificity towards small synthetic substrates

Biochemical and biophysical research communications, 2004-11, Vol.324 (3), p.1116-1123

2004

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A Fluorogenic Histone Deacetylase Assay Well Suited for High-Throughput Activity Screening

Chemistry & biology, 2003, Vol.10 (1), p.61-68

2003

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Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases

Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (13), p.3651-3656

2009

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Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro

Cancer letters, 2008-06, Vol.264 (1), p.21-28

2008

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An active site tyrosine residue is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme

Biochemical journal, 2007-02, Vol.401 (3), p.659-665

2007

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Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay

Biochemical journal, 2008-07, Vol.413 (1), p.143-150

2008

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Robotic alliance of miniaturized synthesis and screening: A case study for the identification of histone deacetylase inhibitors

Engineering in life sciences, 2013-07, Vol.13 (4), p.344-351

2013

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Inhibitor‐mediated stabilization of the conformational structure of a histone deacetylase‐like amidohydrolase

The FEBS journal, 2007-07, Vol.274 (14), p.3578-3588

2007

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Structure of a novel thrombin inhibitor with an uncharged d-amino acid as P1 residue

European journal of medicinal chemistry, 2008-06, Vol.43 (6), p.1330-1335

2008

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Active site tyrosine is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme

Biochemical journal, 2006-10, Vol.401 (3), p.659-665

2006

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Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor

Acta crystallographica. Section F, Structural biology and crystallization communications, 2007-04, Vol.63 (4), p.270-273

2007

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Spatially Encoded Single-Bead Biginelli Synthesis in a Microstructured Silicon Array

Angewandte Chemie (International ed.), 2006-05, Vol.45 (19), p.3102-3106

2006

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Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorogenic assay

Biochemical journal, 2008-06, Vol.413 (1), p.143-150

2008

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Genetic algorithm for the design of molecules with desired properties

Journal of computer-aided molecular design, 2002-08, Vol.16 (8-9), p.551-567

2002

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Spatially Encoded Single‐Bead Biginelli Synthesis in a Microstructured Silicon Array

Angewandte Chemie, 2006-05, Vol.118 (19), p.3174-3178

2006

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Directed evolution towards protease-resistant hirudin variants

Molecular genetics and metabolism, 2003-12, Vol.80 (4), p.451-462

2003

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Evaluation of an optically active crown ether for the chiral separation of di- and tripeptides

Journal of Chromatography A, 1995-11, Vol.716 (1), p.371-379

1995

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Improved fluorogenic histone deacetylase assay for high-throughput-screening applications

Factors affecting the substrate specificity of histone deacetylases

Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases

Histone deacetylases--an important class of cellular regulators with a variety of functions

Histone deacetylase inhibitor assay based on fluorescence resonance energy transfer

A New Amidohydrolase from Bordetella or Alcaligenes Strain FB188 with Similarities to Histone Deacetylases

Thrombin Inhibitors Identified by Computer-Assisted Multiparameter Design

Histone deacetylase inhibitors--turning epigenic mechanisms of gene regulation into tools of therapeutic intervention in malignant and other diseases

Members of the histone deacetylase superfamily differ in substrate specificity towards small synthetic substrates

A Fluorogenic Histone Deacetylase Assay Well Suited for High-Throughput Activity Screening

Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases

Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro

An active site tyrosine residue is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme

Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay

Robotic alliance of miniaturized synthesis and screening: A case study for the identification of histone deacetylase inhibitors

Inhibitor‐mediated stabilization of the conformational structure of a histone deacetylase‐like amidohydrolase

Structure of a novel thrombin inhibitor with an uncharged d-amino acid as P1 residue

Active site tyrosine is essential for amidohydrolase but not for esterase activity of a class 2 histone deacetylase-like bacterial enzyme

Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor

Spatially Encoded Single-Bead Biginelli Synthesis in a Microstructured Silicon Array

Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorogenic assay

Genetic algorithm for the design of molecules with desired properties

Spatially Encoded Single‐Bead Biginelli Synthesis in a Microstructured Silicon Array

Directed evolution towards protease-resistant hirudin variants

Evaluation of an optically active crown ether for the chiral separation of di- and tripeptides

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