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SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

Antimicrobial Agents and Chemotherapy, 2010-02, Vol.54 (2), p.660-672

2010

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The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection

Journal of hepatology, 2012-07, Vol.57 (1), p.47-54

2012

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Discovery of New Medicines

The Textbook of Pharmaceutical Medicine, 2013, p.1-31

2013

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A Preparative Route to Fused Indeno[1,2-e][1,2,4]triazolo[4,3-a]pyrazin-4-ones

Heterocycles, 1999-12, Vol.51 (12), p.2977

1999

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Synthesis and pharmacological properties of 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, a new competitive AMPA/KA receptor antagonist

Drug development research, 1999-11, Vol.48 (3), p.121-129

1999

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Betulinic Acid Derivatives: A New Class of Human Immunodeficiency Virus Type 1 Specific Inhibitors with a New Mode of Action

Journal of medicinal chemistry, 1996-03, Vol.39 (5), p.1056-1068

1996

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Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity

Journal of medicinal chemistry, 2000-06, Vol.43 (12), p.2371-2381

2000

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4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity

Bioorganic & medicinal chemistry letters, 2000-05, Vol.10 (10), p.1133

2000

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Spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives are mixed AMPA and NMDA glycine-site antagonists active in vivo

Bioorganic & medicinal chemistry letters, 1999-10, Vol.9 (20), p.2921-2926

1999

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Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2- a]indeno[1,2- e]pyrazin-8- and -9-carboxylic (acetic) acid AMPA antagonists

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (24), p.2749-2754

2000

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Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (2), p.127-132

2001

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Synthesis of anticonvulsive AMPA antagonists: 4-Oxo-10-substituted-imidazo[1,2- a]indeno[1,2- e]pyrazin-2-carboxylic acid derivatives

Bioorganic & medicinal chemistry letters, 2001-05, Vol.11 (9), p.1205-1210

2001

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8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno-[1,2-e]pyrazines : Highly potent in vivo AMPA antagonists

Bioorganic & medicinal chemistry letters, 2000-03, Vol.10 (6), p.591-596

2000

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Synthesis of anticonvulsive AMPA antagonists

Bioorganic & medicinal chemistry letters, 2001-05, Vol.11 (9), p.1205-1210

2001

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8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones : Highly in vivo potent and selective AMPA receptor antagonists

Bioorganic & medicinal chemistry, 2000-08, Vol.8 (8), p.2211-2217

2000

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4,10-Dihydro-4-oxo-4 H -imidazo[1,2- a ]indeno[1,2- e ]pyrazin-2-carboxylic acid derivatives

Bioorganic & medicinal chemistry letters, 2000-05, Vol.10 (10), p.1133-1137

2000

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8-Methylureido-4,5-dihydro-4-oxo-10 H -imidazo[1,2- a ]indeno-[1,2- e ]pyrazines: highly potent in vivo AMPA antagonists

Bioorganic & medicinal chemistry letters, 2000-03, Vol.10 (6), p.591-596

2000

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A Facile Preparation of Quinazolin-4-(3H)-ones from O-Amido Benzonitriles Using Sodium Perborate

Synthetic communications, 1993-11, Vol.23 (20), p.2833-2837

1993

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An Efficient Preparative Route to Fused Imidazo[1,2-a]pyrazin-4-one Derivatives

Heterocycles, 1999, Vol.50 (1), p.259

1999

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Condensation of lithium diphenylphosphonium diylides with carbonic anhydride derivatives. A new one-pot synthesis of α,β-unsaturated anilides and amidines

Tetrahedron letters, 1992-05, Vol.33 (19), p.2693-2696

1992

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Synthesis of Diphenyldialkylphosphonium Salts

Synthesis (Stuttgart), 1988, Vol.1988 (11), p.911-912

1988

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Reactivity of phosphonium diylids with aldehydes and ketones

Journal of organometallic chemistry, 1988-09, Vol.352 (3), p.C47-C50

1988

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Reaction of lithium diphenylphosphonium di(methylide) with carbonic acid derivatives. A novel access to polyfunctional unsaturated esters and amides

Heteroatom chemistry, 1992-08, Vol.3 (4), p.415-422

1992

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ChemInform Abstract: A Preparative Route to Fused Indeno[1,2-e][1,2,4]triazolo[4,3-a]pyrazin-4-ones

ChemInform, 2000-03, Vol.31 (13), p.no-no

2000

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Use of Phosphonium Diylids in Organic Synthesis

Phosphorus and sulfur and the related elements, 1987-03, Vol.30 (1-2), p.135-138

1987

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SCY-635, a Novel Nonimmunosuppressive Analog of Cyclosporine That Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication In Vitro

The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection

Discovery of New Medicines

A Preparative Route to Fused Indeno[1,2-e][1,2,4]triazolo[4,3-a]pyrazin-4-ones

Synthesis and pharmacological properties of 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, a new competitive AMPA/KA receptor antagonist

Betulinic Acid Derivatives: A New Class of Human Immunodeficiency Virus Type 1 Specific Inhibitors with a New Mode of Action

Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity

4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity

Spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives are mixed AMPA and NMDA glycine-site antagonists active in vivo

Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2- a]indeno[1,2- e]pyrazin-8- and -9-carboxylic (acetic) acid AMPA antagonists

Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action

Synthesis of anticonvulsive AMPA antagonists: 4-Oxo-10-substituted-imidazo[1,2- a]indeno[1,2- e]pyrazin-2-carboxylic acid derivatives

8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno-[1,2-e]pyrazines : Highly potent in vivo AMPA antagonists

Synthesis of anticonvulsive AMPA antagonists

8-methylureido-10-amino-10-methyl-imidazo[1,2-a]indeno[1,2-e] pyrazine-4-ones : Highly in vivo potent and selective AMPA receptor antagonists

4,10-Dihydro-4-oxo-4 H -imidazo[1,2- a ]indeno[1,2- e ]pyrazin-2-carboxylic acid derivatives

8-Methylureido-4,5-dihydro-4-oxo-10 H -imidazo[1,2- a ]indeno-[1,2- e ]pyrazines: highly potent in vivo AMPA antagonists

A Facile Preparation of Quinazolin-4-(3H)-ones from O-Amido Benzonitriles Using Sodium Perborate

An Efficient Preparative Route to Fused Imidazo[1,2-a]pyrazin-4-one Derivatives

Condensation of lithium diphenylphosphonium diylides with carbonic anhydride derivatives. A new one-pot synthesis of α,β-unsaturated anilides and amidines

Synthesis of Diphenyldialkylphosphonium Salts

Reactivity of phosphonium diylids with aldehydes and ketones

Reaction of lithium diphenylphosphonium di(methylide) with carbonic acid derivatives. A novel access to polyfunctional unsaturated esters and amides

ChemInform Abstract: A Preparative Route to Fused Indeno[1,2-e][1,2,4]triazolo[4,3-a]pyrazin-4-ones

Use of Phosphonium Diylids in Organic Synthesis

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