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Covariate modeling in pharmacometrics: General points for consideration

CPT: pharmacometrics and systems pharmacology, 2024-05, Vol.13 (5), p.710-728

2024

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Translating Pharmacometrics to a Pharmacoeconomic Model of COPD

Value in health, 2016-12, Vol.19 (8), p.1026-1032

2016

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Population pharmacokinetic analysis of etrolizumab in patients with moderately‐to‐severely active ulcerative colitis

CPT: pharmacometrics and systems pharmacology, 2022-09, Vol.11 (9), p.1244-1255

2022

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Exposure‐response relationships of etrolizumab in patients with moderately‐to‐severely active ulcerative colitis

CPT: pharmacometrics and systems pharmacology, 2022-09, Vol.11 (9), p.1234-1243

2022

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Population repeated time‐to‐event analysis of exacerbations in asthma patients: A novel approach for predicting asthma exacerbations based on biomarkers, spirometry, and diaries/questionnaires

CPT: pharmacometrics and systems pharmacology, 2021-10, Vol.10 (10), p.1221-1235

2021

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The lasso--a novel method for predictive covariate model building in nonlinear mixed effects models

Journal of pharmacokinetics and pharmacodynamics, 2007-08, Vol.34 (4), p.485-517

2007

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Power, selection bias and predictive performance of the population pharmacokinetic covariate model

Journal of pharmacokinetics and pharmacodynamics, 2004-04, Vol.31 (2), p.109-134

2004

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A pharmacokinetic comparison of anrukinzumab, an anti‐ IL‐13 monoclonal antibody, among healthy volunteers, asthma and ulcerative colitis patients

British journal of clinical pharmacology, 2015-07, Vol.80 (1), p.101-109

2015

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Perl-speaks-NONMEM (PsN)—a Perl module for NONMEM related programming

Computer methods and programs in biomedicine, 2004-08, Vol.75 (2), p.85-94

2004

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Population Pharmacokinetics and Exposure‐Response Relationships of Astegolimab in Patients With Severe Asthma

Journal of clinical pharmacology, 2022-07, Vol.62 (7), p.905-917

2022

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A model-based longitudinal meta-analysis of FEV1 in randomized COPD trials

Clinical pharmacology and therapeutics, 2016-03, Vol.99 (3), p.315-324

2016

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Characterizing Systemic Exposure of Inhaled Drugs: Application to the Long-Acting β2-Agonist PF-00610355

Clinical pharmacokinetics, 2013-06, Vol.52 (6), p.443-452

2013

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A Model for Glucose, Insulin, and Beta-Cell Dynamics in Subjects With Insulin Resistance and Patients With Type 2 Diabetes

Journal of clinical pharmacology, 2010-08, Vol.50 (8), p.861-872

2010

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Predicted heart rate effect of inhaled PF‐00610355, a long acting β‐adrenoceptor agonist, in volunteers and patients with chronic obstructive pulmonary disease

British journal of clinical pharmacology, 2013-11, Vol.76 (5), p.752-762

2013

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Characterizing Systemic Exposure of Inhaled Drugs: Application to the Long-Acting [Beta]^sub 2^-Agonist PF-00610355

Clinical pharmacokinetics, 2013-06, Vol.52 (6), p.443

2013

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Predicting Reductions in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations from FEV1-A Model-Based Meta-Analysis of Literature Data from Controlled Randomized Clinical Trials

Journal of pharmacokinetics and pharmacodynamics, 2015, Vol.42 (S1), p.S63

2015

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Placebo effect model in asthma clinical studies: longitudinal meta-analysis of forced expiratory volume in 1 second

European journal of clinical pharmacology, 2012-08, Vol.68 (8), p.1157-1166

2012

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Longitudinal FEV1 dose–response model for inhaled PF-00610355 and salmeterol in patients with chronic obstructive pulmonary disease

Journal of pharmacokinetics and pharmacodynamics, 2012-12, Vol.39 (6), p.619-634

2012

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Non-Bayesian Knowledge Propagation using Model Model-Based Analysis of Data from Multiple Clinical Studies

Journal of pharmacokinetics and pharmacodynamics, 2008, Vol.35 (1), p.117

2008

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Non-Bayesian knowledge propagation using model-based analysis of data from multiple clinical studies

Journal of pharmacokinetics and pharmacodynamics, 2008-02, Vol.35 (1), p.117-137

2008

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Covariate model building in nonlinear mixed effects models

Ribbing, Jakob

2007

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Covariate modeling in pharmacometrics: General points for consideration

Translating Pharmacometrics to a Pharmacoeconomic Model of COPD

Population pharmacokinetic analysis of etrolizumab in patients with moderately‐to‐severely active ulcerative colitis

Exposure‐response relationships of etrolizumab in patients with moderately‐to‐severely active ulcerative colitis

Population repeated time‐to‐event analysis of exacerbations in asthma patients: A novel approach for predicting asthma exacerbations based on biomarkers, spirometry, and diaries/questionnaires

The lasso--a novel method for predictive covariate model building in nonlinear mixed effects models

Power, selection bias and predictive performance of the population pharmacokinetic covariate model

A pharmacokinetic comparison of anrukinzumab, an anti‐ IL‐13 monoclonal antibody, among healthy volunteers, asthma and ulcerative colitis patients

Perl-speaks-NONMEM (PsN)—a Perl module for NONMEM related programming

Population Pharmacokinetics and Exposure‐Response Relationships of Astegolimab in Patients With Severe Asthma

A model-based longitudinal meta-analysis of FEV1 in randomized COPD trials

Characterizing Systemic Exposure of Inhaled Drugs: Application to the Long-Acting β2-Agonist PF-00610355

A Model for Glucose, Insulin, and Beta-Cell Dynamics in Subjects With Insulin Resistance and Patients With Type 2 Diabetes

Predicted heart rate effect of inhaled PF‐00610355, a long acting β‐adrenoceptor agonist, in volunteers and patients with chronic obstructive pulmonary disease

Characterizing Systemic Exposure of Inhaled Drugs: Application to the Long-Acting [Beta]^sub 2^-Agonist PF-00610355

Predicting Reductions in Chronic Obstructive Pulmonary Disease (COPD) Exacerbations from FEV1-A Model-Based Meta-Analysis of Literature Data from Controlled Randomized Clinical Trials

Placebo effect model in asthma clinical studies: longitudinal meta-analysis of forced expiratory volume in 1 second

Longitudinal FEV1 dose–response model for inhaled PF-00610355 and salmeterol in patients with chronic obstructive pulmonary disease

Non-Bayesian Knowledge Propagation using Model Model-Based Analysis of Data from Multiple Clinical Studies

Non-Bayesian knowledge propagation using model-based analysis of data from multiple clinical studies

Covariate model building in nonlinear mixed effects models

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