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Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates

PloS one, 2022-06, Vol.17 (6), p.e0269749-e0269749

2022

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Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5

PloS one, 2020-05, Vol.15 (5), p.e0231892

2020

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Translational findings for odronextamab: From preclinical research to a first‐in‐human study in patients with CD20+ B‐cell malignancies

Clinical and translational science, 2022-04, Vol.15 (4), p.954-966

2022

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Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels: Results From 2 Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Phase 1 Studies in Healthy Volunteers and Hypercholesterolemic Subjects on Statins

Journal of the American College of Cardiology, 2012-11, Vol.60 (19), p.1888-1898

2012

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A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade

Molecular cancer therapeutics, 2021-10, Vol.20 (10), p.1966-1976

2021

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Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement

The Journal of pharmacology and experimental therapeutics, 2015-04, Vol.353 (1), p.119

2015

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A BCMAxCD3 bispecific T cell–engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells

Blood advances, 2021-03, Vol.5 (5), p.1291-1304

2021

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Preclinical PET imaging with the novel human antibody 89 Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues

Journal for immunotherapy of cancer, 2021-01, Vol.9 (1), p.e002025

2021

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Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

Scientific reports, 2021-07, Vol.11 (1), p.14397-17, Article 14397

2021

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Impact of Glycation on Antibody Clearance

The AAPS journal, 2015-01, Vol.17 (1), p.237-244

2015

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proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

Proceedings of the National Academy of Sciences - PNAS, 2009-06, Vol.106 (24), p.9820-9825

2009

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Placental Transfer of a Fully Human IgG2 Monoclonal Antibody in the Cynomolgus Monkey, Rat, and Rabbit: A Comparative Assessment from during Organogenesis to Late Gestation

Birth defects research. Part B. Developmental and reproductive toxicology, 2014-04, Vol.101 (2), p.178-188

2014

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Investigation of maternal and fetal exposure to an IgG2 monoclonal antibody following biweekly intravaginal administration to cynomolgus monkeys throughout pregnancy

Reproductive toxicology (Elmsford, N.Y.), 2014-09, Vol.48, p.132-137

2014

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Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels

Journal of the American College of Cardiology, 2012-11, Vol.60 (19), p.1888-1898

2012

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Measurement of in vivo therapeutic mAb concentrations: comparison of conventional serum/plasma collection and analysis to dried blood spot sampling

Bioanalysis, 2013-08, Vol.5 (16), p.1979-1990

2013

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Receptor editing occurs frequently during normal B cell development

The Journal of experimental medicine, 1998-10, Vol.188 (7), p.1231-1238

1998

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Evaluation of matrix microsampling methods for therapeutic drug candidate quantification in discovery-stage rodent pharmacokinetic studies

Bioanalysis, 2014-08, Vol.6 (16), p.2135-2146

2014

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Preclinical PET imaging with the novel human antibody 89Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues

Journal for immunotherapy of cancer, 2021-01, Vol.9 (1)

2021

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Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens

Immunity (Cambridge, Mass.), 1998-02, Vol.8 (2), p.209-219

1998

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Purification and Characterization of the Mammaglobin/Lipophilin B Complex, a Promising Diagnostic Marker for Breast Cancer

Biochemistry (Easton), 2002-05, Vol.41 (21), p.6714-6722

2002

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B Cell Receptor Expression Level Determines the Fate of Developing B Lymphocytes: Receptor Editing versus Selection

Proceedings of the National Academy of Sciences - PNAS, 2000-06, Vol.97 (13), p.7435-7439

2000

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Characterization of a proapoptotic antiganglioside GM2 monoclonal antibody and evaluation of its therapeutic effect on melanoma and small cell lung carcinoma xenografts

Cancer research (Chicago, Ill.), 2005-07, Vol.65 (14), p.6425-6434

2005

Volltextzugriff (PDF)

Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects: APPLICATIONS TO BISPECIFIC MOLECULES AND MONOVALENT IgG

The Journal of biological chemistry, 2010-06, Vol.285 (25), p.19637-19646

2010

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Identification and characterization of L985P, a CD20 related family member over-expressed in small cell lung carcinoma

International journal of oncology, 2004-12, Vol.25 (6), p.1583

2004

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Characterization of KLK4 expression and detection of KLK4-specific antibody in prostate cancer patient sera

Oncogene, 2002-10, Vol.21 (46), p.7114-7120

2002

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Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates

Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5

Translational findings for odronextamab: From preclinical research to a first‐in‐human study in patients with CD20+ B‐cell malignancies

Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels: Results From 2 Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Phase 1 Studies in Healthy Volunteers and Hypercholesterolemic Subjects on Statins

A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade

Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement

A BCMAxCD3 bispecific T cell–engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells

Preclinical PET imaging with the novel human antibody 89 Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues

Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

Impact of Glycation on Antibody Clearance

proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates

Placental Transfer of a Fully Human IgG2 Monoclonal Antibody in the Cynomolgus Monkey, Rat, and Rabbit: A Comparative Assessment from during Organogenesis to Late Gestation

Investigation of maternal and fetal exposure to an IgG2 monoclonal antibody following biweekly intravaginal administration to cynomolgus monkeys throughout pregnancy

Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels

Measurement of in vivo therapeutic mAb concentrations: comparison of conventional serum/plasma collection and analysis to dried blood spot sampling

Receptor editing occurs frequently during normal B cell development

Evaluation of matrix microsampling methods for therapeutic drug candidate quantification in discovery-stage rodent pharmacokinetic studies

Preclinical PET imaging with the novel human antibody 89Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues

Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens

Purification and Characterization of the Mammaglobin/Lipophilin B Complex, a Promising Diagnostic Marker for Breast Cancer

B Cell Receptor Expression Level Determines the Fate of Developing B Lymphocytes: Receptor Editing versus Selection

Characterization of a proapoptotic antiganglioside GM2 monoclonal antibody and evaluation of its therapeutic effect on melanoma and small cell lung carcinoma xenografts

Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects: APPLICATIONS TO BISPECIFIC MOLECULES AND MONOVALENT IgG

Identification and characterization of L985P, a CD20 related family member over-expressed in small cell lung carcinoma

Characterization of KLK4 expression and detection of KLK4-specific antibody in prostate cancer patient sera

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