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Ticagrelor: Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Profile: An Update

Clinical pharmacokinetics, 2015-11, Vol.54 (11), p.1125-1138

Teng, Renli

2015

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Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Profile of the Oral Antiplatelet Agent Ticagrelor

Clinical pharmacokinetics, 2012-05, Vol.51 (5), p.305-318

Teng, Renli

2012

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Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers

British journal of clinical pharmacology, 2010-07, Vol.70 (1), p.65-77

2010

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Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y₁₂ receptor antagonist, in healthy subjects

European journal of clinical pharmacology, 2010-05, Vol.66 (5), p.487-496

2010

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A pharmacokinetic interaction study of ticagrelor and digoxin in healthy volunteers

European journal of clinical pharmacology, 2013-10, Vol.69 (10), p.1801-1808

2013

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Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects

Drug metabolism and disposition, 2010-09, Vol.38 (9), p.1514-1521

2010

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Pharmacokinetics, pharmacodynamics, and tolerability of single and multiple doses of ticagrelor in Japanese and Caucasian volunteers

International journal of clinical pharmacology and therapeutics, 2014-06, Vol.52 (6), p.478-491

2014

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Response to Ticagrelor in Clopidogrel Nonresponders and Responders and Effect of Switching Therapies: The RESPOND Study

Circulation (New York, N.Y.), 2010-03, Vol.121 (10), p.1188-1199

2010

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The Effect of Ticagrelor on the Metabolism of Midazolam in Healthy Volunteers

Clinical therapeutics, 2013-07, Vol.35 (7), p.1025-1037

2013

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Effect of genetic variations on ticagrelor plasma levels and clinical outcomes

European heart journal, 2015-08, Vol.36 (29), p.1901-1912

2015

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Effect of rifampicin on the pharmacokinetics and pharmacodynamics of ticagrelor in healthy subjects

European journal of clinical pharmacology, 2013-04, Vol.69 (4), p.877-883

2013

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Effect of ticagrelor on pulmonary function in healthy elderly volunteers and asthma or chronic obstructive pulmonary disease patients

Current medical research and opinion, 2013-05, Vol.29 (5), p.569-577

2013

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Safety, tolerability, pharmacokinetics and pharmacodynamics of high single-ascending doses of ticagrelor in healthy volunteers

International journal of clinical pharmacology and therapeutics, 2013-10, Vol.51 (10), p.795-806

2013

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Pharmacokinetic interaction studies of co-administration of ticagrelor and atorvastatin or simvastatin in healthy volunteers

European journal of clinical pharmacology, 2013-03, Vol.69 (3), p.477-487

2013

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Incidence of Dyspnea and Assessment of Cardiac and Pulmonary Function in Patients With Stable Coronary Artery Disease Receiving Ticagrelor, Clopidogrel, or Placebo in the ONSET/OFFSET Study

Journal of the American College of Cardiology, 2010-07, Vol.56 (3), p.185-193

2010

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Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Patients With Low-Risk ACS Undergoing Ad Hoc PCI

Journal of the American College of Cardiology, 2016-02, Vol.67 (6), p.603-613

2016

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Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients with Stable Coronary Artery Disease: Results from the ONSET-OFFSET and RESPOND Studies

Clinical pharmacokinetics, 2012-06, Vol.51 (6), p.397-409

2012

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Effect of age and gender on pharmacokinetics and pharmacodynamics of a single ticagrelor dose in healthy individuals

European journal of clinical pharmacology, 2012-08, Vol.68 (8), p.1175-1182

2012

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Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y(12) receptor antagonist, in healthy subjects

European journal of clinical pharmacology, 2010-05, Vol.66 (5), p.487

2010

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Evaluation of the Pharmacokinetic Interaction Between Ticagrelor and Venlafaxine, a Cytochrome P-450 2D6 Substrate, in Healthy Subjects

Clinical therapeutics, 2014-09, Vol.36 (9), p.1217-1225

2014

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Effect of the CYP3A inhibitors, diltiazem and ketoconazole, on ticagrelor pharmacokinetics in healthy volunteers

Journal of drug assessment (London, U.K.), 2013-01, Vol.2 (1), p.30-39

2013

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Efficacy, safety and pharmacokinetics of candesartan cilexetil in hypertensive children from 1 to less than 6 years of age

Journal of hypertension, 2010-05, Vol.28 (5), p.1083-1090

2010

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Impact of Diabetes Mellitus on the Pharmacodynamic Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Acute Coronary Syndrome Patients Undergoing Ad Hoc Percutaneous Coronary Intervention

Journal of the American Heart Association, 2017-04, Vol.6 (4)

2017

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Evaluation of the pharmacokinetic interaction between ticagrelor and tolbutamide, a cytochrome P450 2C9 substrate, in healthy volunteers

International journal of clinical pharmacology and therapeutics, 2013-04, Vol.51 (4), p.305-312

2013

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Pharmacokinetics, Pharmacodynamics, and Safety of Ticagrelor in Volunteers With Severe Renal Impairment

Journal of clinical pharmacology, 2012-09, Vol.52 (9), p.1388-1398

2012

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Ticagrelor: Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Profile: An Update

Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Profile of the Oral Antiplatelet Agent Ticagrelor

Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers

Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y₁₂ receptor antagonist, in healthy subjects

A pharmacokinetic interaction study of ticagrelor and digoxin in healthy volunteers

Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects

Pharmacokinetics, pharmacodynamics, and tolerability of single and multiple doses of ticagrelor in Japanese and Caucasian volunteers

Response to Ticagrelor in Clopidogrel Nonresponders and Responders and Effect of Switching Therapies: The RESPOND Study

The Effect of Ticagrelor on the Metabolism of Midazolam in Healthy Volunteers

Effect of genetic variations on ticagrelor plasma levels and clinical outcomes

Effect of rifampicin on the pharmacokinetics and pharmacodynamics of ticagrelor in healthy subjects

Effect of ticagrelor on pulmonary function in healthy elderly volunteers and asthma or chronic obstructive pulmonary disease patients

Safety, tolerability, pharmacokinetics and pharmacodynamics of high single-ascending doses of ticagrelor in healthy volunteers

Pharmacokinetic interaction studies of co-administration of ticagrelor and atorvastatin or simvastatin in healthy volunteers

Incidence of Dyspnea and Assessment of Cardiac and Pulmonary Function in Patients With Stable Coronary Artery Disease Receiving Ticagrelor, Clopidogrel, or Placebo in the ONSET/OFFSET Study

Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Patients With Low-Risk ACS Undergoing Ad Hoc PCI

Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients with Stable Coronary Artery Disease: Results from the ONSET-OFFSET and RESPOND Studies

Effect of age and gender on pharmacokinetics and pharmacodynamics of a single ticagrelor dose in healthy individuals

Pharmacokinetics, pharmacodynamics, tolerability and safety of single ascending doses of ticagrelor, a reversibly binding oral P2Y(12) receptor antagonist, in healthy subjects

Evaluation of the Pharmacokinetic Interaction Between Ticagrelor and Venlafaxine, a Cytochrome P-450 2D6 Substrate, in Healthy Subjects

Effect of the CYP3A inhibitors, diltiazem and ketoconazole, on ticagrelor pharmacokinetics in healthy volunteers

Efficacy, safety and pharmacokinetics of candesartan cilexetil in hypertensive children from 1 to less than 6 years of age

Impact of Diabetes Mellitus on the Pharmacodynamic Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Acute Coronary Syndrome Patients Undergoing Ad Hoc Percutaneous Coronary Intervention

Evaluation of the pharmacokinetic interaction between ticagrelor and tolbutamide, a cytochrome P450 2C9 substrate, in healthy volunteers

Pharmacokinetics, Pharmacodynamics, and Safety of Ticagrelor in Volunteers With Severe Renal Impairment

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