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Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Journal of medicinal chemistry, 1996-04, Vol.39 (9), p.1846-1856

1996

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Selective Cyclooxygenase Inhibitors: Novel 1,2-Diarylcyclopentenes Are Potent and Orally Active COX-2 Inhibitors

Journal of medicinal chemistry, 1994-11, Vol.37 (23), p.3878-3881

1994

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Diarylspiro[2.4]heptenes as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors: Synthesis and Structure−Activity Relationships

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.253-266

1996

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A novel class of apical sodium co-dependent bile acid transporter inhibitors : The 2,3-disubstituted-4-phenylquinolines

Bioorganic & medicinal chemistry letters, 2000-02, Vol.10 (3), p.277-279

2000

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Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists

Journal of medicinal chemistry, 1993, Vol.36 (1), p.101-110

1993

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Elucidation of the insurmountable nature of an angiotensin receptor antagonist, SC-54629

Molecular pharmacology, 1995-01, Vol.47 (1), p.115-120

1995

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In vitro pharmacology of a nonpeptidic angiotensin II receptor antagonist, SC-51316

The Journal of pharmacology and experimental therapeutics, 1992-06, Vol.261 (3), p.1037

1992

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Synthesis and structure-activity relationships of nonpeptide, potent triazolone-based angiotensin II receptor antagonists

Journal of medicinal chemistry, 1993-07, Vol.36 (15), p.2172-2181

1993

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In Vivo Pharmacology of SC-51316, a Nonpeptidic Angiotensin II Receptor Antagonist

American journal of hypertension, 1993-07, Vol.6 (7-Pt-1), p.619-625

1993

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1,2-Diarylcyclopentenes as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Journal of medicinal chemistry, 1995-10, Vol.38 (22), p.4570-4578

1995

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A novel one-pot conversion of methyl sulfones to sulfonamides

Tetrahedron letters, 1994-09, Vol.35 (39), p.7201-7204

1994

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A directed metalation of N-tert-butyl-N-methyl-2-methoxybenzamide. Short syntheses of 2-methoxy-6-methylbenzoic acid and lunularic acid

Journal of organic chemistry, 1990-02, Vol.55 (4), p.1375-1379

1990

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Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 1)

Journal of medicinal chemistry, 2005-09, Vol.48 (18), p.5837-5852

2005

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Central and peripheral actions of a nonpeptidic angiotensin II receptor antagonist

Hypertension (Dallas, Tex. 1979), 1990-06, Vol.15 (6 Pt 2), p.841-847

1990

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Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 2)

Journal of medicinal chemistry, 2005-09, Vol.48 (18), p.5853-5868

2005

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Reaction of 2,5-bis(trifluoromethyl)-1,3,4-oxadiazole with hydrazine. The synthesis of 4-amino-3,5-bis(trifluoromethyl)-4H-1,2,4-triazole

Journal of organic chemistry, 1989-03, Vol.54 (7), p.1760-1762

1989

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Reaction of 2,5-bis(trifluoromethyl)-1,3,4-oxadiazole with primary amines. Synthesis of 4-substituted-3,5-bis(trifluoromethyl)-4H-1,2,4-triazoles

Journal of heterocyclic chemistry, 1989-01, Vol.26 (1), p.225-230

1989

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1H-1,2,4-triazole angiotensin II receptor antagonists: N-phenylpyridinylmethyl and N-pyridinylphenylmethyl analogs of SC-50560

Bioorganic & medicinal chemistry letters, 1994-01, Vol.4 (1), p.99-104

1994

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A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 1,2-benzothiazepines

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3727-3730

2003

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Cyclooxygenase-2 Inhibitors

Current pharmaceutical design, 1995, Vol.1 (2), p.211-220

1995

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A Highly Enantioselective Benzothiepine Synthesis

Journal of organic chemistry, 2000-05, Vol.65 (9), p.2711-2715

2000

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The N-Boc group as an activator for the α-lithiation of carbamates: synthesis of 11-substituted dibenzoxazepines

Heterocycles, 1994-03, Vol.38 (3), p.601-611

1994

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Triazole phosphonates. Electrophilic substitution of 1-substituted-1H-1,2,4-triazoles via lithiated triazole intermediates

Journal of heterocyclic chemistry, 1986-07, Vol.23 (4), p.1257-1262

1986

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Metalation and electrophilic substitution of amine derivatives adjacent to nitrogen: .alpha.-metallo amine synthetic equivalents

Chemical reviews, 1984-10, Vol.84 (5), p.471-523

1984

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Diaryl indenes and benzofurans: Novel classes of potent and selective cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 1995-10, Vol.5 (20), p.2377-2380

1995

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Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Selective Cyclooxygenase Inhibitors: Novel 1,2-Diarylcyclopentenes Are Potent and Orally Active COX-2 Inhibitors

Diarylspiro[2.4]heptenes as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors: Synthesis and Structure−Activity Relationships

A novel class of apical sodium co-dependent bile acid transporter inhibitors : The 2,3-disubstituted-4-phenylquinolines

Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists

Elucidation of the insurmountable nature of an angiotensin receptor antagonist, SC-54629

In vitro pharmacology of a nonpeptidic angiotensin II receptor antagonist, SC-51316

Synthesis and structure-activity relationships of nonpeptide, potent triazolone-based angiotensin II receptor antagonists

In Vivo Pharmacology of SC-51316, a Nonpeptidic Angiotensin II Receptor Antagonist

1,2-Diarylcyclopentenes as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

A novel one-pot conversion of methyl sulfones to sulfonamides

A directed metalation of N-tert-butyl-N-methyl-2-methoxybenzamide. Short syntheses of 2-methoxy-6-methylbenzoic acid and lunularic acid

Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 1)

Central and peripheral actions of a nonpeptidic angiotensin II receptor antagonist

Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 2)

Reaction of 2,5-bis(trifluoromethyl)-1,3,4-oxadiazole with hydrazine. The synthesis of 4-amino-3,5-bis(trifluoromethyl)-4H-1,2,4-triazole

Reaction of 2,5-bis(trifluoromethyl)-1,3,4-oxadiazole with primary amines. Synthesis of 4-substituted-3,5-bis(trifluoromethyl)-4H-1,2,4-triazoles

1H-1,2,4-triazole angiotensin II receptor antagonists: N-phenylpyridinylmethyl and N-pyridinylphenylmethyl analogs of SC-50560

A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 1,2-benzothiazepines

Cyclooxygenase-2 Inhibitors

A Highly Enantioselective Benzothiepine Synthesis

The N-Boc group as an activator for the α-lithiation of carbamates: synthesis of 11-substituted dibenzoxazepines

Triazole phosphonates. Electrophilic substitution of 1-substituted-1H-1,2,4-triazoles via lithiated triazole intermediates

Metalation and electrophilic substitution of amine derivatives adjacent to nitrogen: .alpha.-metallo amine synthetic equivalents

Diaryl indenes and benzofurans: Novel classes of potent and selective cyclooxygenase-2 inhibitors

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