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Muscarinic acetylcholine receptors as CNS drug targets

Pharmacology & therapeutics (Oxford), 2008-02, Vol.117 (2), p.232-243

2008

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The distribution of 5-HT6 receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT6 receptor antagonist [125I]SB-258585

Brain research, 2002-04, Vol.934 (1), p.49-57

2002

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Aripiprazole and its human metabolite are partial agonists at the human dopamine D2 receptor, but the rodent metabolite displays antagonist properties

European journal of pharmacology, 2006-09, Vol.546 (1-3), p.88-94

2006

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Aripiprazole acts as a selective dopamine D 2 receptor partial agonist

Expert opinion on investigational drugs, 2007-06, Vol.16 (6), p.771-775

2007

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Aripiprazole acts as a selective dopamine D2 receptor partial agonist

Expert opinion on investigational drugs, 2007-06, Vol.16 (6), p.771-775

2007

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Design and Synthesis of trans-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1H-3-benzazepine (SB-414796): A Potent and Selective Dopamine D3 Receptor Antagonist

Journal of medicinal chemistry, 2003-11, Vol.46 (23), p.4952-4964

2003

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Implementation of a large-scale ENU mutagenesis program: towards increasing the mouse mutant resource

Mammalian genome, 2000-07, Vol.11 (7), p.500-506

2000

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Evaluation of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder: acquisition and performance of the DRL-60s test

Behavioural brain research, 2000-04, Vol.109 (1), p.27-35

2000

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Epileptogenesis and Enhanced Prepulse Inhibition in GABAB1-Deficient Mice

Molecular and cellular neuroscience, 2001-06, Vol.17 (6), p.1059-1070

2001

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Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040

Psychopharmacologia, 2009, Vol.201 (4), p.483-494

2009

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Reversal of isolation-rearing-induced PPI deficits by an alpha 7 nicotinic receptor agonist

Psychopharmacology, 2005-10, Vol.182 (2), p.214-219

2005

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Chandelier cartridges in the prefrontal cortex are reduced in isolation reared rats

Synapse (New York, N.Y.), 2008-08, Vol.62 (8), p.628-631

2008

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(±) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics

Journal of psychopharmacology (Oxford), 2007-05, Vol.21 (3), p.302-311

2007

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Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat

Behavioural pharmacology, 2008-12, Vol.19 (8), p.765

2008

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Aripiprazole and its human metabolite are partial agonists at the human dopamine D 2 receptor, but the rodent metabolite displays antagonist properties

European journal of pharmacology, 2006-09, Vol.546 (1), p.88-94

2006

Volltextzugriff (PDF)

Reversal of isolation-rearing-induced PPI deficits by an α7 nicotinic receptor agonist

Psychopharmacologia, 2005-10, Vol.182 (2), p.214-219

2005

Volltextzugriff (PDF)

Studies towards the identification of a new generation of atypical antipsychotic agents

Bioorganic & medicinal chemistry letters, 2007-01, Vol.17 (2), p.400-405

2007

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(±) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics: Ketamine

Journal of psychopharmacology (Oxford), 2007, Vol.21 (3), p.302-311

2007

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The identification of a selective dopamine D 2 partial agonist, D 3 antagonist displaying high levels of brain exposure

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.2013-2016

2010

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Effects of the atypical antipsychotics olanzapine and risperidone on plasma prolactin levels in male rats : a comparison with clinical data

Psychopharmacologia, 2006, Vol.184 (1), p.107-114

2006

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In vitro and in vivo characterization of PheTQS, a novel α7 nAChR positive allosteric modulator

Biochemical pharmacology, 2009-10, Vol.78 (7), p.913-913

2009

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The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.2013-2016

2010

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Design and Synthesis of trans-N-[4-[2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2- yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A Potent and Selective Dopamine D3 Receptor Antagonist with High Oral Bioavailability and CNS Penetration in the Rat

Journal of medicinal chemistry, 2000-05, Vol.43 (9), p.1878-1885

2000

Volltextzugriff (PDF)

The identification of a selective dopamine D sub(2) partial agonist, D sub(3) antagonist displaying high levels of brain exposure

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (6), p.2013-2016

2010

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Muscarinic acetylcholine receptors as CNS drug targets

The distribution of 5-HT6 receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT6 receptor antagonist [125I]SB-258585

Aripiprazole and its human metabolite are partial agonists at the human dopamine D2 receptor, but the rodent metabolite displays antagonist properties

Aripiprazole acts as a selective dopamine D 2 receptor partial agonist

Aripiprazole acts as a selective dopamine D2 receptor partial agonist

Design and Synthesis of trans-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1H-3-benzazepine (SB-414796): A Potent and Selective Dopamine D3 Receptor Antagonist

Implementation of a large-scale ENU mutagenesis program: towards increasing the mouse mutant resource

Evaluation of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder: acquisition and performance of the DRL-60s test

Epileptogenesis and Enhanced Prepulse Inhibition in GABAB1-Deficient Mice

Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040

Reversal of isolation-rearing-induced PPI deficits by an alpha 7 nicotinic receptor agonist

Chandelier cartridges in the prefrontal cortex are reduced in isolation reared rats

(±) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics

Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat

Aripiprazole and its human metabolite are partial agonists at the human dopamine D 2 receptor, but the rodent metabolite displays antagonist properties

Reversal of isolation-rearing-induced PPI deficits by an α7 nicotinic receptor agonist

Design and Synthesis of trans - N -[4-[2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2- yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A Potent and Selective Dopamine D 3 Receptor Antagonist with High Oral Bioavailability and CNS Penetration in the Rat

Studies towards the identification of a new generation of atypical antipsychotic agents

(±) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics: Ketamine

The identification of a selective dopamine D 2 partial agonist, D 3 antagonist displaying high levels of brain exposure

Effects of the atypical antipsychotics olanzapine and risperidone on plasma prolactin levels in male rats : a comparison with clinical data

In vitro and in vivo characterization of PheTQS, a novel α7 nAChR positive allosteric modulator

The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure

Design and Synthesis of trans-N-[4-[2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2- yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A Potent and Selective Dopamine D3 Receptor Antagonist with High Oral Bioavailability and CNS Penetration in the Rat

The identification of a selective dopamine D sub(2) partial agonist, D sub(3) antagonist displaying high levels of brain exposure

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