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Structure-activity relationship of verapamil analogs and reversal of multidrug resistance

Biochemical pharmacology, 1995-10, Vol.50 (8), p.1245-1255

1995

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Selective endothelin a antagonism is superior to calcium antagonism and ace inhibition in reducing neointima in collared rabbit carotid arteries

American journal of hypertension, 1997-04, Vol.10 (S2), p.23A-23A

1997

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The Selective Endothelin-A-Receptor Antagonist LU 135.252 Inhibits the Direct Arrhythmogenic Action of Endothelin-1

Journal of cardiovascular pharmacology, 2000, Vol.36 Suppl 1 (5 Suppl 1), p.S314-S316

2000

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Effects of endothelin receptor antagonists on the progression of diabetic nephropathy

Nephron (2015), 2001-02, Vol.87 (2), p.161-169

2001

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Effects of (-)-desmethoxyverapamil on heart and vascular smooth muscle

The Journal of pharmacology and experimental therapeutics, 1987-09, Vol.242 (3), p.1090

1987

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The ET(A) receptor blocker LU 135252 prevents chronic transplant nephropathy in the "Fisher to Lewis" model

Journal of the American Society of Nephrology, 1999-02, Vol.10 (2), p.387-391

1999

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Relationship of antiarrhythmic to inotropic activity and antiarrhythmic qualities of the optical isomers of verapamil

Naunyn-Schmiedeberg's archives of pharmacology, 1976-09, Vol.294 (3), p.285-291

Raschack, M

1976

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Discovery and Optimization of a Novel Class of Orally Active Nonpeptidic Endothelin-A Receptor Antagonists

Journal of medicinal chemistry, 1996-05, Vol.39 (11), p.2123-2128

1996

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The ETA receptor blocker LU 135252 prevents chronic transplant nephropathy in the Fisher to Lewis model

Journal of the American Society of Nephrology, 1999-02, Vol.10 (2), p.387-391

1999

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Long-term effects of the endothelin(A) receptor antagonist LU 135252 and the angiotensin-converting enzyme inhibitor trandolapril on diabetic angiopathy and nephropathy in a chronic type I diabetes mellitus rat model

The Journal of pharmacology and experimental therapeutics, 2000-05, Vol.293 (2), p.351

2000

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Nephroprotection of an ET(A)-receptor blocker (LU 135252) in salt-loaded uninephrectomized stroke-prone spontaneously hypertensive rats

Hypertension (Dallas, Tex. 1979), 1998-04, Vol.31 (4), p.995-1001

1998

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Nephroprotection of an ETA-Receptor Blocker (LU 135252) in Salt-Loaded Uninephrectomized Stroke-Prone Spontaneously Hypertensive Rats

Hypertension (Dallas, Tex. 1979), 1998-04, Vol.31 (4), p.995-1001

1998

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Discovery and synthesis of (S)-3-[2-(3,4-dimethoxyphenyl)ethoxy]-2- (4,6-dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic acid (LU 302872), a novel orally active mixed ET(A)/ET(B) receptor antagonist

Journal of medicinal chemistry, 1999-08, Vol.42 (16), p.3026-3032

1999

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Inhibition by anipamil of epicardial ST elevation and K + liberation after coronary artery occlusion in pigs

Journal of molecular and cellular cardiology, 1986, Vol.18, p.51-51

1986

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Cardioprotective and antihypertensive effects of the new calcium antagonist anipamil in rats and hamsters

Journal of molecular and cellular cardiology, 1986, Vol.18, p.43-43

1986

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Endothelin A Receptor Antagonist LU 135252 Inhibits Hypercholesterolemia-Induced, but Not Deendothelialization-Induced, Atherosclerosis in Rabbit Arteries

Investigative radiology, 2002-06, Vol.37 (6), p.349-355

2002

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The effects of desmethoxyverapamil (D888) on cardiac and vascular smooth muscle preparations

Journal of molecular and cellular cardiology, 1984, Vol.16, p.17-17

1984

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The Endothelin-A Antagonist LU 135 252 Supresses Ischemic Ventricular Extrasystoles and Fibrillation in Pigs and Prevents Hypoxic Cellular Decoupling

Journal of cardiovascular pharmacology, 1998, Vol.31 Suppl 1, p.S145-S148

1998

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Differences in the cardiac actions of the calcium antagonists verapamil and nifedipine

Arzneimittel-Forschung, 1976, Vol.26 (7), p.1330

Raschack, M

1976

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Renal Endothelin System in Diabetes: Comparison of Angiotensin-Converting Enzyme Inhibition and Endothelin-A Antagonism

Journal of cardiovascular pharmacology, 1998, Vol.31 Suppl 1, p.S492-S495

1998

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Adult Human Mesangial Cells (HMCs) Express Endothelin-B-Receptors which Mediate Endothelin-1-Induced Cell Growth

Journal of cardiovascular pharmacology, 2000, Vol.36 Suppl 1 (5 Suppl 1), p.S232-S237

2000

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LU 302 872 and Its Racemate (LU 224 332) Show Balanced Endothelin-A/B Receptor Affinity, High Oral Activity, and Inhibit Human Prostate Tissue Contractions

Journal of cardiovascular pharmacology, 1998, Vol.31 Suppl 1, p.S241-S244

1998

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Lack of an antifibrotic effect of the mixed endothelin A/B receptorantagonist LU 420627 on rat secondary biliary fibrosis in rats

Journal of hepatology, 2000, Vol.32, p.41-41

2000

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Specific endothelin a receptor antagonism retards fibrogenesis in ratbiliary fibrosis

Journal of hepatology, 2000, Vol.32, p.66-66

2000

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Oral anipamil prevents myocardial Ca-overload and necroses in cardiomyopathic hamsters

Journal of molecular and cellular cardiology, 1984, Vol.16, p.62-62

1984

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Structure-activity relationship of verapamil analogs and reversal of multidrug resistance

Selective endothelin a antagonism is superior to calcium antagonism and ace inhibition in reducing neointima in collared rabbit carotid arteries

The Selective Endothelin-A-Receptor Antagonist LU 135.252 Inhibits the Direct Arrhythmogenic Action of Endothelin-1

Effects of endothelin receptor antagonists on the progression of diabetic nephropathy

Effects of (-)-desmethoxyverapamil on heart and vascular smooth muscle

The ET(A) receptor blocker LU 135252 prevents chronic transplant nephropathy in the "Fisher to Lewis" model

Relationship of antiarrhythmic to inotropic activity and antiarrhythmic qualities of the optical isomers of verapamil

Discovery and Optimization of a Novel Class of Orally Active Nonpeptidic Endothelin-A Receptor Antagonists

The ETA receptor blocker LU 135252 prevents chronic transplant nephropathy in the Fisher to Lewis model

Long-term effects of the endothelin(A) receptor antagonist LU 135252 and the angiotensin-converting enzyme inhibitor trandolapril on diabetic angiopathy and nephropathy in a chronic type I diabetes mellitus rat model

Nephroprotection of an ET(A)-receptor blocker (LU 135252) in salt-loaded uninephrectomized stroke-prone spontaneously hypertensive rats

Nephroprotection of an ETA-Receptor Blocker (LU 135252) in Salt-Loaded Uninephrectomized Stroke-Prone Spontaneously Hypertensive Rats

Discovery and synthesis of (S)-3-[2-(3,4-dimethoxyphenyl)ethoxy]-2- (4,6-dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic acid (LU 302872), a novel orally active mixed ET(A)/ET(B) receptor antagonist

Inhibition by anipamil of epicardial ST elevation and K + liberation after coronary artery occlusion in pigs

Cardioprotective and antihypertensive effects of the new calcium antagonist anipamil in rats and hamsters

Endothelin A Receptor Antagonist LU 135252 Inhibits Hypercholesterolemia-Induced, but Not Deendothelialization-Induced, Atherosclerosis in Rabbit Arteries

The effects of desmethoxyverapamil (D888) on cardiac and vascular smooth muscle preparations

The Endothelin-A Antagonist LU 135 252 Supresses Ischemic Ventricular Extrasystoles and Fibrillation in Pigs and Prevents Hypoxic Cellular Decoupling

Differences in the cardiac actions of the calcium antagonists verapamil and nifedipine

Renal Endothelin System in Diabetes: Comparison of Angiotensin-Converting Enzyme Inhibition and Endothelin-A Antagonism

Adult Human Mesangial Cells (HMCs) Express Endothelin-B-Receptors which Mediate Endothelin-1-Induced Cell Growth

LU 302 872 and Its Racemate (LU 224 332) Show Balanced Endothelin-A/B Receptor Affinity, High Oral Activity, and Inhibit Human Prostate Tissue Contractions

Lack of an antifibrotic effect of the mixed endothelin A/B receptorantagonist LU 420627 on rat secondary biliary fibrosis in rats

Specific endothelin a receptor antagonism retards fibrogenesis in ratbiliary fibrosis

Oral anipamil prevents myocardial Ca-overload and necroses in cardiomyopathic hamsters

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