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Patient-centered drug discovery as the means to improved R&D productivity

Drug discovery today, 2015-09, Vol.20 (9), p.1044-1048

2015

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Pharmacokinetics and Pharmacodynamics of TMC207 and Its N-Desmethyl Metabolite in a Murine Model of Tuberculosis

Antimicrobial Agents and Chemotherapy, 2012-03, Vol.56 (3), p.1444-1451

2012

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Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects

Drug metabolism and disposition, 2009-04, Vol.37 (4), p.809-820

2009

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TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors

Antimicrobial Agents and Chemotherapy, 2011-12, Vol.55 (12), p.5723-5731

2011

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Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs

European journal of pharmaceutical sciences, 2002-11, Vol.17 (3), p.131-138

2002

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Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate

Journal of pharmaceutical sciences, 2004-06, Vol.93 (6), p.1431-1439

2004

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Clinical Pharmacokinetics and Pharmacodynamics of Etravirine

Clinical pharmacokinetics, 2009-01, Vol.48 (9), p.561-574

2009

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Assessment of regional differences in intestinal fluid movement in the rat using a modified in situ single pass perfusion model

Pharmaceutical research, 1998-08, Vol.15 (8), p.1314-1316

1998

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Is there a justification for a separate juvenile toxicity study in pre-weaned rats?

Reproductive toxicology (Elmsford, N.Y.), 2011-09, Vol.32 (2), p.165-165

2011

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Real life juvenile toxicity case studies: The good, the bad and the ugly

Reproductive toxicology (Elmsford, N.Y.), 2008-09, Vol.26 (1), p.54-55

2008

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The Evaluation of New Antituberculosis Drugs in Children

2011

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In vivo assessment of intestinal, hepatic, and pulmonary first pass metabolism of propofol in the rat

Pharmaceutical research, 1996-06, Vol.13 (6), p.891-895

1996

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GLUCURONIDATION OF DIFLUNISAL, (−)-MORPHINE, 4-NITROPHENOL, AND PROPOFOL IN LIVER MICROSOMES OF TWO PATIENTS WITH CRIGLER-NAJJAR SYNDROME TYPE I

Biopharmaceutics & drug disposition, 1996-05, Vol.17 (4), p.311-317

1996

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Patient-centered drug discovery as the means to improved R&D productivity

Pharmacokinetics and Pharmacodynamics of TMC207 and Its N-Desmethyl Metabolite in a Murine Model of Tuberculosis

Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects

TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors

Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs

Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate

Clinical Pharmacokinetics and Pharmacodynamics of Etravirine

Assessment of regional differences in intestinal fluid movement in the rat using a modified in situ single pass perfusion model

Is there a justification for a separate juvenile toxicity study in pre-weaned rats?

Real life juvenile toxicity case studies: The good, the bad and the ugly

The Evaluation of New Antituberculosis Drugs in Children

In vivo assessment of intestinal, hepatic, and pulmonary first pass metabolism of propofol in the rat

GLUCURONIDATION OF DIFLUNISAL, (−)-MORPHINE, 4-NITROPHENOL, AND PROPOFOL IN LIVER MICROSOMES OF TWO PATIENTS WITH CRIGLER-NAJJAR SYNDROME TYPE I

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