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Chemoenzymatic methods for site-specific protein modification

Current opinion in chemical biology, 2010-12, Vol.14 (6), p.790-796

Rabuka, David

2010

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Pictet-Spengler ligation for protein chemical modification

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (1), p.46-51

2013

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Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (9), p.3000-3005

2009

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Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag

Angewandte Chemie (International ed.), 2012-04, Vol.51 (17), p.4161-4165

International ed. in English, 2012

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Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells

Oncoimmunology, 2019-01, Vol.8 (4), p.e1565859-e1565859

2019

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Synthesis and Microcontact Printing of Dual End-Functionalized Mucin-like Glycopolymers for Microarray Applications

Angewandte Chemie (International ed.), 2009-01, Vol.48 (27), p.4973-4976

2009

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A Chemical Reporter Strategy to Probe Glycoprotein Fucosylation

Journal of the American Chemical Society, 2006-09, Vol.128 (37), p.12078-12079

2006

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Site-Specific Labeling of Proteins Using the Formylglycine-Generating Enzyme (FGE)

Methods in molecular biology (Clifton, N.J.), 2019-01, Vol.2012, p.63

2019

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Control of the Molecular Orientation of Membrane-Anchored Biomimetic Glycopolymers

Journal of the American Chemical Society, 2009-07, Vol.131 (29), p.10263-10268

2009

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Abstract 2662: Site specific ADC generation using SMARTag technology with programmable payload placement

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.2662-2662

Rabuka, David

2014

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Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer

Antibodies (Basel), 2019-11, Vol.8 (4), p.54

2019

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Recent Advances in Chemoenzymatic Bioconjugation Methods

Organic Chemistry Insights, 2015-07, Vol.2015 (2015), p.7-14

2015

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Recent Developments in ADC Technology: Preclinical Studies Signal Future Clinical Trends

BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy, 2017-12, Vol.31 (6), p.521-531

2017

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An emerging playbook for antibody–drug conjugates: lessons from the laboratory and clinic suggest a strategy for improving efficacy and safety

Current opinion in chemical biology, 2015-10, Vol.28, p.174-180

2015

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Developing site-specifically modified ADCs using a chemoenzymatic approach

Journal of biotechnology & biomaterials, 2018, Vol.8

Rabuka, David

2018

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Systematic LC/MS/MS Investigations for the IND-Enabling Extended Characterization of Antibody–Drug Conjugate Modifications

Antibodies (Basel), 2018-12, Vol.7 (4), p.40

2018

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Discovery and engineering of AiEvo2, a novel Cas12a nuclease for human gene editing applications

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.105685-105685, Article 105685

2024

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Site-specific chemical protein conjugation using genetically encoded aldehyde tags

Nature protocols, 2012-06, Vol.7 (6), p.1052-1067

2012

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Cas9 degradation in human cells using phage anti-CRISPR proteins

PLoS biology, 2023-12, Vol.21 (12), p.e3002431-e3002431

2023

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Leveraging Formylglycine-Generating Enzyme for Production of Site-Specifically Modified Bioconjugates

Methods in molecular biology (Clifton, N.J.), 2018, Vol.1728, p.3

2018

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Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes

Bioconjugate chemistry, 2014-07, Vol.25 (7), p.1331-1341

2014

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Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody–Drug Conjugates

Bioconjugate chemistry, 2021-04, Vol.32 (4), p.746-754

2021

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Site-Specific Bioconjugation Using SMARTag ® Technology: A Practical and Effective Chemoenzymatic Approach to Generate Antibody-Drug Conjugates

Methods in molecular biology (Clifton, N.J.), 2019, Vol.2033, p.131

2019

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CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity

Nature chemical biology, 2019-10, Vol.15 (10), p.949-958

2019

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Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates

Bioconjugate chemistry, 2013-06, Vol.24 (6), p.846-851

2013

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Chemoenzymatic methods for site-specific protein modification

Pictet-Spengler ligation for protein chemical modification

Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag

Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag

Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells

Synthesis and Microcontact Printing of Dual End-Functionalized Mucin-like Glycopolymers for Microarray Applications

A Chemical Reporter Strategy to Probe Glycoprotein Fucosylation

Site-Specific Labeling of Proteins Using the Formylglycine-Generating Enzyme (FGE)

Control of the Molecular Orientation of Membrane-Anchored Biomimetic Glycopolymers

Abstract 2662: Site specific ADC generation using SMARTag technology with programmable payload placement

Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer

Recent Advances in Chemoenzymatic Bioconjugation Methods

Recent Developments in ADC Technology: Preclinical Studies Signal Future Clinical Trends

An emerging playbook for antibody–drug conjugates: lessons from the laboratory and clinic suggest a strategy for improving efficacy and safety

Developing site-specifically modified ADCs using a chemoenzymatic approach

Systematic LC/MS/MS Investigations for the IND-Enabling Extended Characterization of Antibody–Drug Conjugate Modifications

Discovery and engineering of AiEvo2, a novel Cas12a nuclease for human gene editing applications

Site-specific chemical protein conjugation using genetically encoded aldehyde tags

Cas9 degradation in human cells using phage anti-CRISPR proteins

Leveraging Formylglycine-Generating Enzyme for Production of Site-Specifically Modified Bioconjugates

Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes

Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody–Drug Conjugates

Site-Specific Bioconjugation Using SMARTag ® Technology: A Practical and Effective Chemoenzymatic Approach to Generate Antibody-Drug Conjugates

CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity

Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates

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