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Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development

European journal of nuclear medicine and molecular imaging, 2020-02, Vol.47 (2), p.451-489

2020

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Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Nature communications, 2020-01, Vol.11 (1), p.246-246, Article 246

2020

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The Development, Past Achievements, and Future Directions of Brain PET

Journal of Cerebral Blood Flow & Metabolism, 2012-07, Vol.32 (7), p.1426-1454

2012

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Positron emission tomography molecular imaging for drug development

British journal of clinical pharmacology, 2012-02, Vol.73 (2), p.175-186

2012

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An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

Journal of cerebral blood flow and metabolism, 2012-01, Vol.32 (1), p.1-5

2012

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Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography

Cerebral cortex (New York, N.Y. 1991), 2014-05, Vol.24 (5), p.1165-1177

2014

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Reduced mu opioid receptor availability in schizophrenia revealed with [ 11 C]-carfentanil positron emission tomographic Imaging

Nature communications, 2019-10, Vol.10 (1), p.4493-9, Article 4493

2019

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Neuroinflammation and its relationship to changes in brain volume and white matter lesions in multiple sclerosis

Brain (London, England : 1878), 2017-11, Vol.140 (11), p.2927-2938

2017

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Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load

Molecular psychiatry, 2021-10, Vol.26 (10), p.5848-5855

2021

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Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited

Journal of cerebral blood flow and metabolism, 2010-01, Vol.30 (1), p.46-50

2010

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PET Radioligands for imaging of the PDE10A in human: current status

Neuroscience letters, 2019-01, Vol.691, p.11-17

2019

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TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis

Biochemical journal, 2017-11, Vol.474 (23), p.3985-3999

2017

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The histamine system and cognitive function: An in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia

Journal of psychopharmacology (Oxford), 2023-10, Vol.37 (10), p.1011-1022

2023

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The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

Translational psychiatry, 2021-07, Vol.11 (1), p.393-393, Article 393

2021

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Translational PET imaging research

Neurobiology of disease, 2014-01, Vol.61, p.32-38

2014

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Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis

Biological psychiatry (1969), 2016-07, Vol.80 (1), p.62-72

2016

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Serotonin release measured in the human brain: a PET study with [ 11 C]CIMBI-36 and d-amphetamine challenge

Neuropsychopharmacology (New York, N.Y.), 2020-04, Vol.45 (5), p.804-810

2020

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Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals

Molecular psychiatry, 2022-04, Vol.27 (4), p.2019-2029

2022

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Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus

Journal of Nuclear Medicine, 2018-07, Vol.59 (7), p.1125-1132

2018

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Specific and non-specific binding of a tracer for the translocator-specific protein in schizophrenia: an [11C]-PBR28 blocking study

European journal of nuclear medicine and molecular imaging, 2021-10, Vol.48 (11), p.3530-3539

2021

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Imaging in Central Nervous System Drug Discovery

Seminars in nuclear medicine, 2017-01, Vol.47 (1), p.89-98

2017

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Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals

Molecular psychiatry, 2020-08, Vol.25 (8), p.1749-1758

2020

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Fibromyalgia patients show an abnormal dopamine response to pain

The European journal of neuroscience, 2007-06, Vol.25 (12), p.3576-3582

2007

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Endogenous dopamine release in the human brain as a pharmacodynamic biomarker: evaluation of the new GPR139 agonist TAK-041 with [ 11 C]PHNO PET

Neuropsychopharmacology (New York, N.Y.), 2022-06, Vol.47 (7), p.1405-1412

2022

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The application of positron emission tomography (PET) imaging in CNS drug development

Brain imaging and behavior, 2019-04, Vol.13 (2), p.354-365

2019

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Advances in CNS PET: the state-of-the-art for new imaging targets for pathophysiology and drug development

Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

The Development, Past Achievements, and Future Directions of Brain PET

Positron emission tomography molecular imaging for drug development

An 18-kDa Translocator Protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography

Reduced mu opioid receptor availability in schizophrenia revealed with [ 11 C]-carfentanil positron emission tomographic Imaging

Neuroinflammation and its relationship to changes in brain volume and white matter lesions in multiple sclerosis

Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load

Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited

PET Radioligands for imaging of the PDE10A in human: current status

TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis

The histamine system and cognitive function: An in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia

The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

Translational PET imaging research

Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis

Serotonin release measured in the human brain: a PET study with [ 11 C]CIMBI-36 and d-amphetamine challenge

Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals

Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus

Specific and non-specific binding of a tracer for the translocator-specific protein in schizophrenia: an [11C]-PBR28 blocking study

Imaging in Central Nervous System Drug Discovery

Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals

Fibromyalgia patients show an abnormal dopamine response to pain

Endogenous dopamine release in the human brain as a pharmacodynamic biomarker: evaluation of the new GPR139 agonist TAK-041 with [ 11 C]PHNO PET

The application of positron emission tomography (PET) imaging in CNS drug development

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