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Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing

Clinical pharmacology and therapeutics, 2013-12, Vol.94 (6), p.640-645

2013

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Quantitative Contribution of rs75017182 to Dihydropyrimidine Dehydrogenase mRNA Splicing and Enzyme Activity

Clinical pharmacology and therapeutics, 2017-10, Vol.102 (4), p.662-670

2017

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Novel Deleterious Dihydropyrimidine Dehydrogenase Variants May Contribute to 5‐Fluorouracil Sensitivity in an East African Population

Clinical pharmacology and therapeutics, 2017-03, Vol.101 (3), p.382-390

2017

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A DPYD Variant (Y186C) in Individuals of African Ancestry Is Associated With Reduced DPD Enzyme Activity

Clinical pharmacology and therapeutics, 2013-07, Vol.94 (1), p.158-166

2013

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Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy

Annals of oncology, 2008-05, Vol.19 (5), p.915-919

2008

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Colorectal Tumors Responding to 5-Fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthase, and Thymidine Phosphorylase

Clinical cancer research, 2000-04, Vol.6 (4), p.1322-1327

2000

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Life-Threatening Toxicity in a Dihydropyrimidine Dehydrogenase-deficient Patient after Treatment with Topical 5-Fluorouracil

Clinical cancer research, 1999-08, Vol.5 (8), p.2006-2011

1999

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Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver : population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy

Cancer research (Chicago, Ill.), 1993-11, Vol.53 (22), p.5433-5438

1993

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Dihydropyrimidine dehydrogenase: its role in 5-fluorouracil clinical toxicity and tumor resistance

Clinical cancer research, 1999-10, Vol.5 (10), p.2672

1999

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Response to "A Case of 5-FU-Related Severe Toxicity Associated With the P.Y186C DPYD Variant"

Clinical pharmacology and therapeutics, 2014-02, Vol.95 (2), p.137-137

2014

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Sorivudine and 5‐fluorouracil; a clinically significant drug‐drug interaction due to inhibition of dihydropyrimidine dehydrogenase

British journal of clinical pharmacology, 1998-07, Vol.46 (1), p.1-4

Diasio, Robert B.

1998

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Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: implication for 5-fluorouracil-based chemotherapy

Clinical cancer research, 1998-02, Vol.4 (2), p.325-329

1998

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Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase

The Journal of biological chemistry, 1994-07, Vol.269 (30), p.19375-19379

1994

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Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy

Leukemia, 2014-01, Vol.28 (1), p.147-154

2014

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Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: implication in 5-fluorouracil-based chemotherapy

Clinical cancer research, 1997-03, Vol.3 (3), p.395-399

1997

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Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency

Clinical cancer research, 1996-03, Vol.2 (3), p.477-481

1996

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Clinical pharmacology of 5-fluorouracil

Clinical pharmacokinetics, 1989-04, Vol.16 (4), p.215-237

1989

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Purification and characterization of dihydropyrimidine dehydrogenase from human liver

The Journal of biological chemistry, 1992-08, Vol.267 (24), p.17102-17109

1992

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Familial deficiency of dihydropyrimidine dehydrogenase: biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity

The Journal of clinical investigation, 1988, Vol.81 (1), p.47-51

1988

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Single-nucleotide polymorphism rs1052501 associated with monoclonal gammopathy of undetermined significance and multiple myeloma

Leukemia, 2013-02, Vol.27 (2), p.515-516

2013

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Improving fluorouracil chemotherapy with novel orally administered fluoropyrimidines

Drugs (Basel), 1999, Vol.58 (Supplement 3), p.119-126

DIASIO, R. B

1999

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Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion

Cancer research (Chicago, Ill.), 1990, Vol.50 (1), p.197-201

1990

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Phase I and Pharmacologic Study of Oral Fluorouracil on a Chronic Daily Schedule in Combination With the Dihydropyrimidine Dehydrogenase Inactivator Eniluracil

Journal of clinical oncology, 2000-02, Vol.18 (4), p.915-926

2000

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Quantitation of Dihydropyrimidine Dehydrogenase Expression by Real-Time Reverse Transcription Polymerase Chain Reaction

Analytical biochemistry, 2000-02, Vol.278 (2), p.175-184

2000

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Dihydropyrimidine dehydrogenase activity and fluorouracil chemotherapy

Journal of clinical oncology, 1994-11, Vol.12 (11), p.2239-2242

1994

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Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing

Quantitative Contribution of rs75017182 to Dihydropyrimidine Dehydrogenase mRNA Splicing and Enzyme Activity

Novel Deleterious Dihydropyrimidine Dehydrogenase Variants May Contribute to 5‐Fluorouracil Sensitivity in an East African Population

A DPYD Variant (Y186C) in Individuals of African Ancestry Is Associated With Reduced DPD Enzyme Activity

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy

Colorectal Tumors Responding to 5-Fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthase, and Thymidine Phosphorylase

Life-Threatening Toxicity in a Dihydropyrimidine Dehydrogenase-deficient Patient after Treatment with Topical 5-Fluorouracil

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver : population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy

Dihydropyrimidine dehydrogenase: its role in 5-fluorouracil clinical toxicity and tumor resistance

Response to "A Case of 5-FU-Related Severe Toxicity Associated With the P.Y186C DPYD Variant"

Sorivudine and 5‐fluorouracil; a clinically significant drug‐drug interaction due to inhibition of dihydropyrimidine dehydrogenase

Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: implication for 5-fluorouracil-based chemotherapy

Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase

Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy

Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: implication in 5-fluorouracil-based chemotherapy

Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency

Clinical pharmacology of 5-fluorouracil

Purification and characterization of dihydropyrimidine dehydrogenase from human liver

Familial deficiency of dihydropyrimidine dehydrogenase: biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity

Single-nucleotide polymorphism rs1052501 associated with monoclonal gammopathy of undetermined significance and multiple myeloma

Improving fluorouracil chemotherapy with novel orally administered fluoropyrimidines

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion

Phase I and Pharmacologic Study of Oral Fluorouracil on a Chronic Daily Schedule in Combination With the Dihydropyrimidine Dehydrogenase Inactivator Eniluracil

Quantitation of Dihydropyrimidine Dehydrogenase Expression by Real-Time Reverse Transcription Polymerase Chain Reaction

Dihydropyrimidine dehydrogenase activity and fluorouracil chemotherapy

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