UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 59

Sortiert nach

Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9703-9723

2017

Volltextzugriff (PDF)

Improved efficacy/safety profile of factor XIa inhibitor BMS‐724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys

Research and practice in thrombosis and haemostasis, 2021-05, Vol.5 (4), p.e12524-n/a, Article e12524

2021

Volltextzugriff (PDF)

In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa

Journal of thrombosis and thrombolysis, 2015-11, Vol.40 (4), p.416-423

2015

Volltextzugriff (PDF)

Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1729-1744

2005

Volltextzugriff (PDF)

Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors

Bioorganic & medicinal chemistry letters, 2023-05, Vol.88, p.129304, Article 129304

2023

Volltextzugriff (PDF)

Factor XIa Inhibitors as New Anticoagulants

Journal of medicinal chemistry, 2018-09, Vol.61 (17), p.7425-7447

2018

Volltextzugriff (PDF)

Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (21), p.127474-127474, Article 127474

2020

Volltextzugriff (PDF)

Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.955-969

2014

Volltextzugriff (PDF)

Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (21), p.127495-127495, Article 127495

2020

Volltextzugriff (PDF)

Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker

Journal of medicinal chemistry, 2017-02, Vol.60 (3), p.1060-1075

2017

Volltextzugriff (PDF)

Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors

Bioorganic & medicinal chemistry letters, 2018-04, Vol.28 (6), p.987-992

2018

Volltextzugriff (PDF)

Macrocyclic factor XIa inhibitors

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (17), p.4056-4060

2017

Volltextzugriff (PDF)

Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.9915-9932

2014

Volltextzugriff (PDF)

Design, structure–activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors

Bioorganic & medicinal chemistry, 2007-12, Vol.17 (23), p.6481-6488

2007

Volltextzugriff (PDF)

Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (16), p.3833-3839

2017

Volltextzugriff (PDF)

Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group

Bioorganic & medicinal chemistry, 2016-05, Vol.24 (10), p.2257-2272

2016

Volltextzugriff (PDF)

Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1635-1642

2015

Volltextzugriff (PDF)

Novel phenylalanine derived diamides as Factor XIa inhibitors

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.472-478

2016

Volltextzugriff (PDF)

Pyridine and pyridinone-based factor XIa inhibitors

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.925-930

2015

Volltextzugriff (PDF)

Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 2

Journal of medicinal chemistry, 1999-07, Vol.42 (15), p.2760-2773

1999

Volltextzugriff (PDF)

Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 1

Journal of medicinal chemistry, 1999-07, Vol.42 (15), p.2752-2759

1999

Volltextzugriff (PDF)

Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)‑one as the P2′ Moiety

ACS medicinal chemistry letters, 2015-05, Vol.6 (5), p.590-595

2015

Volltextzugriff (PDF)

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Journal of medicinal chemistry, 2001-02, Vol.44 (4), p.566-578

2001

Volltextzugriff (PDF)

Constrictive binding of large guests by a hemicarcerand containing four portals

Journal of the American Chemical Society, 1991-03, Vol.113 (7), p.2754-2755

1991

Volltextzugriff (PDF)

1 – 25 von 59

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(52)
Mit Volltextzugriff
(54)

Publikationsform

Artikel
(58)
Buchkapitel
(1)

Sprache

Englisch
(59)
Japanisch
(8)

Erscheinungsjahr

n.n

Thema

Science & Technology
(40)
Life Sciences & Biomedicine
(38)
Pharmacology & Pharmacy
(34)
Chemistry, Medicinal
(29)
Humans
(24)
Chemistry
(23)
Physical Sciences
(22)
Animals
(21)
Chemistry, Organic
(20)
Biological And Medical Sciences
(18)
Medical Sciences
(18)
Factor Xa Inhibitors
(16)
Pharmacology. Drug Treatments
(16)
Structure-Activity Relationship
(16)
Rabbits
(15)
Blood. Blood Coagulation. Reticuloendothelial System
(14)
Models, Molecular
(13)
Thrombosis
(13)
Crystallography, X-Ray
(11)
Dogs
(11)

15 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)

Improved efficacy/safety profile of factor XIa inhibitor BMS‐724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys

In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa

Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors

Factor XIa Inhibitors as New Anticoagulants

Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors

Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors

Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies

Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker

Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors

Macrocyclic factor XIa inhibitors

Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity

Design, structure–activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors

Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency

Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group

Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties

Novel phenylalanine derived diamides as Factor XIa inhibitors

Pyridine and pyridinone-based factor XIa inhibitors

Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 2

Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 1

Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)‑one as the P2′ Moiety

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-( R)-hydroxy- N-pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4- c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa

Constrictive binding of large guests by a hemicarcerand containing four portals

Suchergebnisse filtern