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Structural basis for the inhibition of Polo-like kinase 1

Nature structural & molecular biology, 2013-09, Vol.20 (9), p.1047

2013

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PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (27), p.13394-13403

2019

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Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation

Nature communications, 2023-10, Vol.14 (1), p.6132-6132, Article 6132

2023

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Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer’s Disease

Journal of medicinal chemistry, 2017-08, Vol.60 (15), p.6664-6677

2017

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Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination

Cellular oncology (Dordrecht), 2022-12, Vol.45 (6), p.1347-1361

2022

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Optical imaging of non-fluorescent nanodiamonds in live cells using transient absorption microscopy

Nanoscale, 2013-06, Vol.5 (11), p.4701-4705

2013

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L2DTL/CDT2 and PCNA Interact with p53 and Regulate p53 Polyubiquitination and Protein Stability through MDM2 and CUL4A/DDB1 Complexes

Cell cycle (Georgetown, Tex.), 2006-08, Vol.5 (15), p.1719-1729

2006

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Formal Synthesis of Cortistatins

Journal of organic chemistry, 2011-04, Vol.76 (8), p.2479-2487

2011

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Benzo[e]isoindole-1,3-diones as Potential Inhibitors of Glycogen Synthase Kinase-3 (GSK-3). Synthesis, Kinase Inhibitory Activity, Zebrafish Phenotype, and Modeling of Binding Mode

Journal of medicinal chemistry, 2010-02, Vol.53 (3), p.994-1003

2010

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Feedback activation of CD73-Adenosine axis attenuates the antitumor immunity of STING pathway

Biochemical and biophysical research communications, 2024-05, Vol.708, p.149814-149814, Article 149814

2024

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Development of a novel anti-inflammatory recombinant uricase with extended half-life for gout therapy

Biochemical and biophysical research communications, 2023-07, Vol.666, p.115-121

2023

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Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays

PloS one, 2009-02, Vol.4 (2), p.e4361-e4361

2009

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STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity

Cancer letters, 2019-05, Vol.450, p.110-122

2019

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Cyclopeptide Inhibitors Target the N‐Terminal Tail of STING and Alleviate Autoinflammation

Chemistry & biodiversity, 2024-07, p.e202401253

2024

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A novel CyclinE/CyclinA-CDK Inhibitor targets p27Kip1 degradation, cell cycle progression and cell survival: Implications in cancer therapy

Cancer letters, 2013-06, Vol.333 (1), p.103-112

2013

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Identification of α‐Mangostin as an Agonist of Human STING

ChemMedChem, 2018-10, Vol.13 (19), p.2057-2064

2018

Volltextzugriff (PDF)

Identification of DNA aptamers that specifically targets EBV+ nasopharyngeal carcinoma via binding with EphA2/CD98hc complex

Biochemical and biophysical research communications, 2022-06, Vol.608, p.135-141

2022

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An Efficient One-Pot Asymmetric Synthesis of Biaryl Compounds via Diels−Alder/Retro-Diels−Alder Cascade Reactions

Organic letters, 2007-03, Vol.9 (5), p.805-808

2007

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S-acylthioalkyl ester (SATE)-based prodrugs of deoxyribose cyclic dinucleotides (dCDNs) as the STING agonist for antitumor immunotherapy

European journal of medicinal chemistry, 2022-12, Vol.243, p.114796-114796, Article 114796

2022

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N-cystaminylbiguanide MC001 prevents neuron cell death and alleviates motor deficits in the MPTP-model of Parkinson’s disease

Neuroscience letters, 2022-07, Vol.784, p.136751-136751, Article 136751

2022

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Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8

Scientific reports, 2018-11, Vol.8 (1), p.16723-10, Article 16723

2018

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Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties

Cancer research (Chicago, Ill.), 2011-12, Vol.71 (23), p.7238-7249

2011

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Biguanide MC001, a Dual Inhibitor of OXPHOS and Glycolysis, Shows Enhanced Antitumor Activity Without Increasing Lactate Production

ChemMedChem, 2022-03, Vol.17 (6), p.e202100674-n/a

2022

Volltextzugriff (PDF)

Mitochondria-Targeted Approach: Remarkably Enhanced Cellular Bioactivities of TPP2a as Selective Inhibitor and Probe toward TrxR

ACS chemical biology, 2016-02, Vol.11 (2), p.425-434

2016

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Stabilizing amyloid-β peptide by the N-terminus capture is capable of preventing and eliminating amyloid-β oligomers

Chemical communications (Cambridge, England), 2017-07, Vol.53 (54), p.7673-7676

2017

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Structural basis for the inhibition of Polo-like kinase 1

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation

Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer’s Disease

Blockade of USP14 potentiates type I interferon signaling and radiation-induced antitumor immunity via preventing IRF3 deubiquitination

Optical imaging of non-fluorescent nanodiamonds in live cells using transient absorption microscopy

L2DTL/CDT2 and PCNA Interact with p53 and Regulate p53 Polyubiquitination and Protein Stability through MDM2 and CUL4A/DDB1 Complexes

Formal Synthesis of Cortistatins

Benzo[e]isoindole-1,3-diones as Potential Inhibitors of Glycogen Synthase Kinase-3 (GSK-3). Synthesis, Kinase Inhibitory Activity, Zebrafish Phenotype, and Modeling of Binding Mode

Feedback activation of CD73-Adenosine axis attenuates the antitumor immunity of STING pathway

Development of a novel anti-inflammatory recombinant uricase with extended half-life for gout therapy

Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays

STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity

Cyclopeptide Inhibitors Target the N‐Terminal Tail of STING and Alleviate Autoinflammation

A novel CyclinE/CyclinA-CDK Inhibitor targets p27Kip1 degradation, cell cycle progression and cell survival: Implications in cancer therapy

Identification of α‐Mangostin as an Agonist of Human STING

Identification of DNA aptamers that specifically targets EBV+ nasopharyngeal carcinoma via binding with EphA2/CD98hc complex

An Efficient One-Pot Asymmetric Synthesis of Biaryl Compounds via Diels−Alder/Retro-Diels−Alder Cascade Reactions

S-acylthioalkyl ester (SATE)-based prodrugs of deoxyribose cyclic dinucleotides (dCDNs) as the STING agonist for antitumor immunotherapy

N-cystaminylbiguanide MC001 prevents neuron cell death and alleviates motor deficits in the MPTP-model of Parkinson’s disease

Structural basis for dimerization of the death effector domain of the F122A mutant of Caspase-8

Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties

Biguanide MC001, a Dual Inhibitor of OXPHOS and Glycolysis, Shows Enhanced Antitumor Activity Without Increasing Lactate Production

Mitochondria-Targeted Approach: Remarkably Enhanced Cellular Bioactivities of TPP2a as Selective Inhibitor and Probe toward TrxR

Stabilizing amyloid-β peptide by the N-terminus capture is capable of preventing and eliminating amyloid-β oligomers

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