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Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Nature communications, 2018-12, Vol.9 (1), p.5138-13, Article 5138

2018

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Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

Molecular cell, 2017-04, Vol.66 (1), p.154-162.e10

2017

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Targeting STAT3 by a small molecule suppresses pancreatic cancer progression

Oncogene, 2021-02, Vol.40 (8), p.1440-1457

2021

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Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

Cell metabolism, 2011-01, Vol.13 (1), p.44-56

2011

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Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate

Cell research, 2022-03, Vol.32 (3), p.288-301

2022

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Associations between the levels of circulating inflammatory adipokines and the risk of type 2 diabetes in Chinese male individuals: A case–control study

Journal of clinical laboratory analysis, 2023-03, Vol.37 (6), p.e24875-n/a

2023

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Diastereoselective synthesis of 3,3-disubstituted 3-nitro-4-chromanone derivatives as potential antitumor agents

Organic & biomolecular chemistry, 2019-01, Vol.17 (5), p.162-166

2019

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Synthesis of heterocyclic ring-fused tricyclic diterpene analogs as novel inhibitors of RANKL-induced osteoclastogenesis and bone resorption

European journal of medicinal chemistry, 2017-05, Vol.131, p.48-67

2017

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Synthesis and biological evaluation of 3-nitro-4-chromanone derivatives as potential antiproliferative agents for castration-resistant prostate cancer

RSC advances, 2019-10, Vol.9 (58), p.33794-33799

2019

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Synthesis and Preliminary Evaluation of [11C]GNE‐1023 as a Potent PET Probe for Imaging Leucine‐Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease

ChemMedChem, 2019-09, Vol.14 (17), p.1580-1585

2019

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Maslinic acid induces mitochondrial apoptosis and suppresses HIF-1α expression in A549 lung cancer cells under normoxic and hypoxic conditions

Molecules (Basel, Switzerland), 2014-11, Vol.19 (12), p.19892-19906

2014

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Synthesis of Lithocholic Acid from Plant-sourced Bisnoralcohol

Organic preparations and procedures international, 2022-07, Vol.54 (4), p.355-362

2022

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Discovery of methylpyrimidine ring-fused diterpenoid analogs as a novel testosterone synthesis promoter

RSC advances, 2019-01, Vol.9 (17), p.9709-9717

2019

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Synthesis of Novel Heterocyclic Ring-Fused 18β-Glycyrrhetinic Acid Derivatives with Antitumor and Antimetastatic Activity

Chemical biology & drug design, 2014-08, Vol.84 (2), p.223-233

2014

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Biodegradable Redox-Sensitive Star Polymer Nanomicelles for Enhancing Doxorubicin Delivery

Nanomaterials (Basel, Switzerland), 2019-04, Vol.9 (4), p.547

2019

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A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened

Cell chemical biology, 2024-07, Vol.31 (7), p.1264-1276.e7

2024

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Synthesis and Biological Evaluation of Heterocyclic Ring-Fused Betulinic Acid Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption

Journal of medicinal chemistry, 2012-04, Vol.55 (7), p.3122-3134

2012

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Synthesis of Heterocyclic Ring-Fused Bisnoralcohol Derivatives as Novel Small-Molecule Antiosteoporosis Agents

Journal of medicinal chemistry, 2024-05, Vol.67 (10), p.8271-8295

2024

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Synthesis and Biological Evaluation of Heterocyclic Ring-Fused 20(S)‑Protopanaxadiol Derivatives as Potent Antiosteoporosis Agents

Journal of medicinal chemistry, 2023-09, Vol.66 (17), p.11965-11984

2023

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Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol

European journal of medicinal chemistry, 2022-06, Vol.236, p.114323-114323, Article 114323

2022

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Synthesis and nonlinear optical absorption properties of two new conjugated ferrocene-bridge-pyridinium compounds

Tetrahedron, 2007-09, Vol.63 (37), p.9188-9194

2007

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Synthesis of ursodeoxycholic acid from plant-source (20S)-21-hydroxy-20-methylpregn-4-en-3-one

Steroids, 2020-05, Vol.157, p.108600-108600, Article 108600

2020

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The synthesis and antibacterial activity of pyrazole-fused tricyclic diterpene derivatives

European journal of medicinal chemistry, 2015-01, Vol.90, p.10-20

2015

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Selective Formation of Six-Membered Oxa- and Carbocycles by the In(III)-Activated Ring Closure of Acetylenic Substrates

Organic letters, 2011-11, Vol.13 (21), p.5893-5895

2011

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Activity-Based Protein Profiling for Type I Methionine Aminopeptidase by Using Photo-Affinity Trimodular Probes

Chembiochem : a European journal of chemical biology, 2007-08, Vol.8 (12), p.1351-1358

2007

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Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

Targeting STAT3 by a small molecule suppresses pancreatic cancer progression

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate

Associations between the levels of circulating inflammatory adipokines and the risk of type 2 diabetes in Chinese male individuals: A case–control study

Diastereoselective synthesis of 3,3-disubstituted 3-nitro-4-chromanone derivatives as potential antitumor agents

Synthesis of heterocyclic ring-fused tricyclic diterpene analogs as novel inhibitors of RANKL-induced osteoclastogenesis and bone resorption

Synthesis and biological evaluation of 3-nitro-4-chromanone derivatives as potential antiproliferative agents for castration-resistant prostate cancer

Synthesis and Preliminary Evaluation of [11C]GNE‐1023 as a Potent PET Probe for Imaging Leucine‐Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease

Maslinic acid induces mitochondrial apoptosis and suppresses HIF-1α expression in A549 lung cancer cells under normoxic and hypoxic conditions

Synthesis of Lithocholic Acid from Plant-sourced Bisnoralcohol

Discovery of methylpyrimidine ring-fused diterpenoid analogs as a novel testosterone synthesis promoter

Synthesis of Novel Heterocyclic Ring-Fused 18β-Glycyrrhetinic Acid Derivatives with Antitumor and Antimetastatic Activity

Biodegradable Redox-Sensitive Star Polymer Nanomicelles for Enhancing Doxorubicin Delivery

A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened

Synthesis and Biological Evaluation of Heterocyclic Ring-Fused Betulinic Acid Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption

Synthesis of Heterocyclic Ring-Fused Bisnoralcohol Derivatives as Novel Small-Molecule Antiosteoporosis Agents

Synthesis and Biological Evaluation of Heterocyclic Ring-Fused 20(S)‑Protopanaxadiol Derivatives as Potent Antiosteoporosis Agents

Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol

Synthesis and nonlinear optical absorption properties of two new conjugated ferrocene-bridge-pyridinium compounds

Synthesis of ursodeoxycholic acid from plant-source (20S)-21-hydroxy-20-methylpregn-4-en-3-one

The synthesis and antibacterial activity of pyrazole-fused tricyclic diterpene derivatives

Selective Formation of Six-Membered Oxa- and Carbocycles by the In(III)-Activated Ring Closure of Acetylenic Substrates

Activity-Based Protein Profiling for Type I Methionine Aminopeptidase by Using Photo-Affinity Trimodular Probes

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