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Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist

The Journal of pharmacology and experimental therapeutics, 2008-12, Vol.327 (3), p.736-745

2008

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Promotion of sleep by targeting the orexin system in rats, dogs and humans

Nature medicine, 2007-02, Vol.13 (2), p.150-155

2007

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The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats

The Journal of pharmacology and experimental therapeutics, 2006-03, Vol.316 (3), p.1115-1121

2006

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Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System

The Journal of pharmacology and experimental therapeutics, 2004-10, Vol.311 (1), p.204-212

2004

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Identification of Cathepsin L as a Potential Sex-Specific Biomarker for Renal Damage

Hypertension (Dallas, Tex. 1979), 2011-04, Vol.57 (4), p.795-801

2011

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Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction

Journal of the American College of Cardiology, 2002-01, Vol.39 (1), p.142-147

2002

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Chronic Endothelin Receptor Blockade Prevents Both Early Hyperfiltration and Late Overt Diabetic Nephropathy in the Rat

Journal of cardiovascular pharmacology, 2003-07, Vol.42 (1), p.48-54

2003

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Endothelin and angiotensin mediate most glomerular responses to nitric oxide inhibition

Kidney international, 1999-06, Vol.55 (6), p.2390-2396

1999

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Comparison of L-type and mixed L- and T-type calcium channel blockers on kidney injury caused by deoxycorticosterone-salt hypertension in rats

American journal of kidney diseases, 2001-12, Vol.38 (6), p.1292-1297

2001

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Dexamethasone worsens nitric oxide inhibition-induced hypertension and renal dysfunction

American journal of hypertension, 2000-10, Vol.13 (10), p.1097-1102

2000

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Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure

Cardiovascular research, 2002-03, Vol.53 (4), p.963-970

2002

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Inhibition of inducible nitric oxide synthase during high dietary salt intake

American journal of hypertension, 2002-03, Vol.15 (3), p.230-235

2002

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Bosentan, Sildenafil, and Their Combination in the Monocrotaline Model of Pulmonary Hypertension in Rats

Experimental biology and medicine (Maywood, N.J.), 2006-06, Vol.231 (6), p.967-973

2006

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Endothelin Mediates the Altered Renal Hemodynamics Associated with Experimental Congestive Heart Failure

Journal of cardiovascular pharmacology, 2001-08, Vol.38 (2), p.317-324

2001

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Protective Effects of Endothelin Receptor Antagonists in Dogs with Aortic Cross-Clamping

Journal of cardiovascular pharmacology, 1999-08, Vol.34 (2), p.199-205

1999

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Optimizing vascular gene transfer of plasminogen activator inhibitor 1

Human gene therapy, 1999-06, Vol.10 (9), p.1469-1478

1999

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Mibefradil prevents L-NAME-exacerbated nephrosclerosis in spontaneously hypertensive rats

Journal of hypertension, 1999-10, Vol.17 (10), p.1489-1495

1999

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Renal Effects of Acute Amino Acid Infusion in Hypertension Induced by Chronic Nitric Oxide Blockade

Hypertension (Dallas, Tex. 1979), 1995-01, Vol.25 (1), p.61-66

1995

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Effects of Nonpeptide Endothelin Receptor Antagonists in Rats with Reduced Renal Mass

Journal of cardiovascular pharmacology, 1999-04, Vol.33 (4), p.611-618

1999

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Renal Vascular and Biochemical Responses to Systemic Renin Inhibition in Dogs at Low Renal Perfusion Pressure

Journal of cardiovascular pharmacology, 1999-11, Vol.34 (5), p.674-682

1999

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Urodilatin Binds to and Activates Renal Receptors for Atrial Natriuretic Peptide

Hypertension (Dallas, Tex. 1979), 1993-04, Vol.21 (4), p.432-438

1993

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Actions of endogenous endothelin on glomerular hemodynamics in the rat

American journal of physiology. Regulatory, integrative and comparative physiology, 1995-08, Vol.38 (2), p.R469-R473

1995

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Importance of nitric oxide in the control of renal hemodynamics

Kidney international, 1996-06, Vol.49 (6), p.1727-1731

1996

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Acute changes in urinary excretion of nitrite + nitrate do not necessarily predict renal vascular NO production

Kidney international, 1995-10, Vol.48 (4), p.1272-1277

1995

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Evolution of Chronic Nitric Oxide Inhibition Hypertension: Relationship to Renal Function

Hypertension (Dallas, Tex. 1979), 1998-01, Vol.31 (1), p.21-26

1998

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Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist

Promotion of sleep by targeting the orexin system in rats, dogs and humans

The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats

Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System

Identification of Cathepsin L as a Potential Sex-Specific Biomarker for Renal Damage

Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction

Chronic Endothelin Receptor Blockade Prevents Both Early Hyperfiltration and Late Overt Diabetic Nephropathy in the Rat

Endothelin and angiotensin mediate most glomerular responses to nitric oxide inhibition

Comparison of L-type and mixed L- and T-type calcium channel blockers on kidney injury caused by deoxycorticosterone-salt hypertension in rats

Dexamethasone worsens nitric oxide inhibition-induced hypertension and renal dysfunction

Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure

Inhibition of inducible nitric oxide synthase during high dietary salt intake

Bosentan, Sildenafil, and Their Combination in the Monocrotaline Model of Pulmonary Hypertension in Rats

Endothelin Mediates the Altered Renal Hemodynamics Associated with Experimental Congestive Heart Failure

Protective Effects of Endothelin Receptor Antagonists in Dogs with Aortic Cross-Clamping

Optimizing vascular gene transfer of plasminogen activator inhibitor 1

Mibefradil prevents L-NAME-exacerbated nephrosclerosis in spontaneously hypertensive rats

Renal Effects of Acute Amino Acid Infusion in Hypertension Induced by Chronic Nitric Oxide Blockade

Effects of Nonpeptide Endothelin Receptor Antagonists in Rats with Reduced Renal Mass

Renal Vascular and Biochemical Responses to Systemic Renin Inhibition in Dogs at Low Renal Perfusion Pressure

Urodilatin Binds to and Activates Renal Receptors for Atrial Natriuretic Peptide

Actions of endogenous endothelin on glomerular hemodynamics in the rat

Importance of nitric oxide in the control of renal hemodynamics

Acute changes in urinary excretion of nitrite + nitrate do not necessarily predict renal vascular NO production

Evolution of Chronic Nitric Oxide Inhibition Hypertension: Relationship to Renal Function

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