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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Nature communications, 2017-05, Vol.8 (1), p.15522-15522, Article 15522

2017

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Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Nature communications, 2017-07, Vol.8 (1), p.103-14, Article 103

2017

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Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

Journal of Virology, 2009-10, Vol.83 (19), p.10058-10074

2009

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Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Nature communications, 2019-06, Vol.10 (1), p.2527-2527, Article 2527

2019

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NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes

ACS chemical biology, 2014-10, Vol.9 (10), p.2247-2254

2014

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Mechanism of Resistance of Hepatitis C Virus Replicons to Structurally Distinct Cyclophilin Inhibitors

Antimicrobial Agents and Chemotherapy, 2010-05, Vol.54 (5), p.1981-1987

2010

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The Alternative Sigma Factor SigH Regulates Major Components of Oxidative and Heat Stress Responses in Mycobacterium tuberculosis

Journal of Bacteriology, 2001-10, Vol.183 (20), p.6119-6125

2001

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Mycobacterium tuberculosis SigM Positively Regulates Esx Secreted Protein and Nonribosomal Peptide Synthetase Genes and Down Regulates Virulence-Associated Surface Lipid Synthesis

Journal of Bacteriology, 2006-12, Vol.188 (24), p.8460-8468

2006

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Role of the AcrAB-TolC Efflux Pump in Determining Susceptibility of Haemophilus influenzae to the Novel Peptide Deformylase Inhibitor LBM415

Antimicrobial Agents and Chemotherapy, 2005-08, Vol.49 (8), p.3129-3135

2005

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Identification of 2‑Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay

Biochemistry (Easton), 2023-07, Vol.62 (14), p.2147-2160

2023

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A Mycobacterial Extracytoplasmic Sigma Factor Involved in Survival following Heat Shock and Oxidative Stress

Journal of Bacteriology, 1999-07, Vol.181 (14), p.4266-4274

1999

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Two-Dimensional Direct-Reading Fluorescence Spectrograph for DNA Sequencing by Capillary Array Electrophoresis

Analytical chemistry (Washington), 2001-03, Vol.73 (6), p.1234-1239

2001

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Reduced Susceptibility of Haemophilus influenzae to the Peptide Deformylase Inhibitor LBM415 Can Result from Target Protein Overexpression Due to Amplified Chromosomal def Gene Copy Number

Antimicrobial Agents and Chemotherapy, 2007-03, Vol.51 (3), p.1004-1010

2007

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Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer

Molecular cancer therapeutics, 2022-06, Vol.21 (6), p.890-902

2022

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Abstract PS12-23: Development of H3B-6545, a first-in-class oral selective ER covalent antagonist (SERCA), for the treatment of ERaWT and ERaMUT breast cancer

Cancer research (Chicago, Ill.), 2021-02, Vol.81 (4_Supplement), p.PS12-23-PS12-23

2021

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IS1626, a new IS900-related Mycobacterium avium insertion sequence

Microbiology (Society for General Microbiology), 1999-11, Vol.145 ( Pt 11), p.3163

1999

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Abstract 3013: Identification of PHF5A as a common cellular target of splicing-modulating chemical probes

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.3013-3013

2016

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Abstract 126: A chemogenomic approach reveals the action of splicing modulators at the branch point adenosine binding pocket defined by the PHF5A/SF3b complex

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.126-126

2017

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Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.DDT01-04-DDT01-04

2017

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Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα WT and ERα MUT Breast Cancer

Cancer discovery, 2018-09, Vol.8 (9), p.1176-1193

2018

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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Journal of visualized experiments, 2015-12 (106), p.e52879-e52879

2015

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Abstract 2932: SF3B1 mutations induce aberrant mRNA splicing in cancer and confer sensitivity to spliceosome inhibition

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.2932-2932

2014

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Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Journal of visualized experiments, 2015-12 (106)

2015

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Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes

Mechanism of Resistance of Hepatitis C Virus Replicons to Structurally Distinct Cyclophilin Inhibitors

The Alternative Sigma Factor SigH Regulates Major Components of Oxidative and Heat Stress Responses in Mycobacterium tuberculosis

Mycobacterium tuberculosis SigM Positively Regulates Esx Secreted Protein and Nonribosomal Peptide Synthetase Genes and Down Regulates Virulence-Associated Surface Lipid Synthesis

Role of the AcrAB-TolC Efflux Pump in Determining Susceptibility of Haemophilus influenzae to the Novel Peptide Deformylase Inhibitor LBM415

Identification of 2‑Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay

A Mycobacterial Extracytoplasmic Sigma Factor Involved in Survival following Heat Shock and Oxidative Stress

Two-Dimensional Direct-Reading Fluorescence Spectrograph for DNA Sequencing by Capillary Array Electrophoresis

Reduced Susceptibility of Haemophilus influenzae to the Peptide Deformylase Inhibitor LBM415 Can Result from Target Protein Overexpression Due to Amplified Chromosomal def Gene Copy Number

Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer

Abstract PS12-23: Development of H3B-6545, a first-in-class oral selective ER covalent antagonist (SERCA), for the treatment of ERaWT and ERaMUT breast cancer

IS1626, a new IS900-related Mycobacterium avium insertion sequence

Abstract 3013: Identification of PHF5A as a common cellular target of splicing-modulating chemical probes

Abstract 126: A chemogenomic approach reveals the action of splicing modulators at the branch point adenosine binding pocket defined by the PHF5A/SF3b complex

Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer

Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα WT and ERα MUT Breast Cancer

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Abstract 2932: SF3B1 mutations induce aberrant mRNA splicing in cancer and confer sensitivity to spliceosome inhibition

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Cancer-Associated Mutations in SF3B1 Exhibit Neomorphic Splicing Activity and Block Erythroid Differentiation

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