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Chemical and semisynthetic approaches to study and target deubiquitinases

Chemical Society reviews, 2016-07, Vol.45 (15), p.4171-4198

2016

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Benzisothiazolone Derivatives Exhibit Cytotoxicity in Hodgkin's Lymphoma Cells through NF-κB Inhibition and are Synergistic with Doxorubicin and Etoposide

Anti-cancer agents in medicinal chemistry, 2020-01, Vol.20 (6), p.715

2020

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Analysis of Inhibition Potential of Nimbin and its Analogs against NF-κB Subunits p50 and p65: A Molecular Docking and Molecular Dynamics Study

Anti-cancer agents in medicinal chemistry, 2024-01, Vol.24 (4), p.280

2024

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Functionalized Sulfur-Containing Heterocyclic Analogs Induce Sub-G1 Arrest and Apoptotic Cell Death of Laryngeal Carcinoma In Vitro

Molecules (Basel, Switzerland), 2023-02, Vol.28 (4), p.1856

2023

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Environmentally Benign Transamidation Protocol for Weakly Nucleophilic Aromatic Amines with N‐Acyl‐2‐piperidinones: Catalyst‐, Additive‐, Base‐ and Solvent‐Free Condition

Asian journal of organic chemistry, 2022-09, Vol.11 (9), p.n/a

2022

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Highly Chemoselective Esterification Reactions and Boc/THP/TBDMS Discriminating Deprotections under Samarium(III) Catalysis

Organic letters, 2011-04, Vol.13 (8), p.1932-1935

2011

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Peptide turns through just ‘one atom’! A sulfamide group nucleates folding and stabilizes new supramolecular topologies in short peptides

CrystEngComm, 2014-01, Vol.16 (45), p.10371-10375

2014

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Role of Post‐translational Modifications in Alzheimer's Disease

Chembiochem : a European journal of chemical biology, 2020-04, Vol.21 (8), p.1052-1079

2020

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6‐Gingerol and Semisynthetic 6‐Gingerdione Counteract Oxidative Stress Induced by ROS in Zebrafish

Chemistry & biodiversity, 2021-12, Vol.18 (12), p.e2100650-n/a

2021

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Target identification of anticancer natural products using a chemical proteomics approach

RSC advances, 2021-08, Vol.11 (45), p.2795-27964

2021

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Cover Feature: Role of Post‐translational Modifications in Alzheimer's Disease (ChemBioChem 8/2020)

Chembiochem : a European journal of chemical biology, 2020-04, Vol.21 (8), p.1051-1051

2020

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An efficient Turn-ON fluorescent probe for fluoride ions – Meticulous investigations and development of arduino microcomputer integrated smartphone device

Journal of molecular liquids, 2022-01, Vol.345, p.117042, Article 117042

2022

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Hydroxyl containing benzo[b]thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle

Life sciences (1973), 2022-06, Vol.298, p.120507-120507, Article 120507

2022

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Deacetylepoxyazadiradione ameliorates diabesity in in-vivo zebrafish larval model by influencing the level of regulatory adipokines and oxidative stress

European journal of pharmacology, 2023-12, Vol.961, p.176214-176214, Article 176214

2023

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A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N‑Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation

Journal of the American Chemical Society, 2021-07, Vol.143 (26), p.9798-9812

2021

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Nano-sized aggregation induced emissive probe for highly sensitive hypochlorous acid detection

Dyes and pigments, 2023-02, Vol.210, p.111016, Article 111016

2023

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6-Gingerol-derived semisynthetic analogs mitigate oxidative stress, and reverse acrylamide induced neurotoxicity in zebrafish

New journal of chemistry, 2023-06, Vol.47 (22), p.1488-1492

2023

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Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae

Brain research, 2022-08, Vol.1788, p.147941-147941, Article 147941

2022

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Site‐Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Angewandte Chemie (International ed.), 2020-03, Vol.59 (10), p.4059-4067

International ed. in English, 2020

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Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2

Chemical science (Cambridge), 2016-01, Vol.7 (12), p.7079-7086

2016

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6‐Gingerdione Reduces Apoptotic Conditions in HepG2 Cells and Inhibits Inflammatory Cytokine Gene Expression in Alcoholic Liver Injured Zebrafish Larvae

Chemistry & biodiversity, 2023-01, Vol.20 (1), p.e202200959-n/a

2023

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Nimbin analog N2 alleviates high testosterone induced oxidative stress in CHO cells and alters the expression of Tox3 and Dennd1a signal transduction pathway involved in the PCOS zebrafish

Phytotherapy research, 2023-04, Vol.37 (4), p.1449-1461

2023

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Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating the levels of inflammatory cytokines in zebrafish larval model

Molecular and cellular biochemistry, 2022-10, Vol.477 (10), p.2387-2401

2022

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Withaferin A targets the membrane of Pseudomonas aeruginosa and mitigates the inflammation in zebrafish larvae; an in vitro and in vivo approach

Microbial pathogenesis, 2022-11, Vol.172, p.105778-105778, Article 105778

2022

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Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β-cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase (PEPCK) and insulin levels

Toxicology and applied pharmacology, 2022-11, Vol.454, p.116229-116229, Article 116229

2022

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Chemical and semisynthetic approaches to study and target deubiquitinases

Benzisothiazolone Derivatives Exhibit Cytotoxicity in Hodgkin's Lymphoma Cells through NF-κB Inhibition and are Synergistic with Doxorubicin and Etoposide

Analysis of Inhibition Potential of Nimbin and its Analogs against NF-κB Subunits p50 and p65: A Molecular Docking and Molecular Dynamics Study

Functionalized Sulfur-Containing Heterocyclic Analogs Induce Sub-G1 Arrest and Apoptotic Cell Death of Laryngeal Carcinoma In Vitro

Environmentally Benign Transamidation Protocol for Weakly Nucleophilic Aromatic Amines with N‐Acyl‐2‐piperidinones: Catalyst‐, Additive‐, Base‐ and Solvent‐Free Condition

Highly Chemoselective Esterification Reactions and Boc/THP/TBDMS Discriminating Deprotections under Samarium(III) Catalysis

Peptide turns through just ‘one atom’! A sulfamide group nucleates folding and stabilizes new supramolecular topologies in short peptides

Role of Post‐translational Modifications in Alzheimer's Disease

6‐Gingerol and Semisynthetic 6‐Gingerdione Counteract Oxidative Stress Induced by ROS in Zebrafish

Target identification of anticancer natural products using a chemical proteomics approach

Cover Feature: Role of Post‐translational Modifications in Alzheimer's Disease (ChemBioChem 8/2020)

An efficient Turn-ON fluorescent probe for fluoride ions – Meticulous investigations and development of arduino microcomputer integrated smartphone device

Hydroxyl containing benzo[b]thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle

Deacetylepoxyazadiradione ameliorates diabesity in in-vivo zebrafish larval model by influencing the level of regulatory adipokines and oxidative stress

A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N‑Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation

Nano-sized aggregation induced emissive probe for highly sensitive hypochlorous acid detection

6-Gingerol-derived semisynthetic analogs mitigate oxidative stress, and reverse acrylamide induced neurotoxicity in zebrafish

Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae

Site‐Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2

6‐Gingerdione Reduces Apoptotic Conditions in HepG2 Cells and Inhibits Inflammatory Cytokine Gene Expression in Alcoholic Liver Injured Zebrafish Larvae

Nimbin analog N2 alleviates high testosterone induced oxidative stress in CHO cells and alters the expression of Tox3 and Dennd1a signal transduction pathway involved in the PCOS zebrafish

Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating the levels of inflammatory cytokines in zebrafish larval model

Withaferin A targets the membrane of Pseudomonas aeruginosa and mitigates the inflammation in zebrafish larvae; an in vitro and in vivo approach

Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β-cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase (PEPCK) and insulin levels

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