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The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates

PloS one, 2015-09, Vol.10 (9), p.e0135388

2015

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2403 Comparison of effect of sorafenib (SOR) and CBL0137 (CBL), a novel drug targeting facilitates chromatin transcription (FACT) complex in woodchuck model of hepatitis B-related hepatocellular carcinoma (HCC)

European journal of cancer (1990), 2015-09, Vol.51, p.S471-S471

2015

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A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications

Communications biology, 2021-04, Vol.4 (1), p.466-466, Article 466

2021

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New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase

The Journal of biological chemistry, 1994-07, Vol.269 (29), p.18814-18820

1994

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FACT inhibitor CBL0137, administered in an optimized schedule, potentiates radiation therapy for glioblastoma by suppressing DNA damage repair

Journal of neuro-oncology, 2024-09

2024

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Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma

Neuro-oncology (Charlottesville, Va.), 2017-02, Vol.19 (2), p.186-196

2017

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Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models

Cancer research (Chicago, Ill.), 2016-04, Vol.76 (8), p.2432-2442

2016

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Synthesis of Carbazole Derivative PLX01107 and its Pharmacokinetics for Various Administration Routes in CD-1 Mice

Pharmaceutical chemistry journal, 2017-05, Vol.51 (2), p.100-106

2017

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Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT

Science translational medicine, 2011-08, Vol.3 (95), p.95ra74

2011

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422 CBL0137, a novel NFkB suppressor and p53 activator, is highly effective in pre-clinical models of neuroblastoma

European journal of cancer (1990), 2014-11, Vol.50, p.135-135

2014

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Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer

Cell cycle (Georgetown, Tex.), 2009-12, Vol.8 (24), p.4155-4167

2009

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Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas

Cancer research (Chicago, Ill.), 2016-11, Vol.76 (22), p.6620-6630

2016

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Multiply damaged sites in DNA: interactions with Escherichia coli endonucleases III and VIII

Nucleic acids research, 1998-02, Vol.26 (4), p.932-941

1998

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Prevention of Colorectal Carcinogenesis by DNA-Binding Small-Molecule Curaxin CBL0137 Involves Suppression of Wnt Signaling

Cancer prevention research (Philadelphia, Pa.), 2020-01, Vol.13 (1), p.53-64

2020

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Enzymatic Processing of Uracil Glycol, a Major Oxidative Product of DNA Cytosine

The Journal of biological chemistry, 1998-04, Vol.273 (16), p.10026-10035

1998

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Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in vitro

Nucleic acids research, 1994-01, Vol.22 (1), p.72-78

1994

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Antitumor effect of the curaxin CBL0137 on the models of colon cancer

Uspehi molekulârnoj onkologii, 2016-09, Vol.3 (3), p.67-72

2016

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Genotoxicity of two new carbazole derivatives with antifungal activity

Mutation research. Genetic toxicology and environmental mutagenesis, 2017-04, Vol.816-817, p.24-31

2017

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Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice

Cancer prevention research (Philadelphia, Pa.), 2012-08, Vol.5 (8), p.1025-1035

2012

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alpha.-Deoxyadenosine, a Major Anoxic Radiolysis Product of Adenine in DNA, Is a Substrate for Escherichia coli Endonuclease IV

Biochemistry (Easton), 1994-06, Vol.33 (25), p.7842-7847

1994

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Process for the preparation of pathogen-inactivated RBC concentrates by using PEN110 chemistry: preclinical studies

Transfusion (Philadelphia, Pa.), 2002-02, Vol.42 (2), p.139-145

2002

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Inactivation of Gram-negative and Gram-positive bacteria in red cell concentrates using INACTINE PEN110 chemistry

Vox sanguinis, 2004-10, Vol.87 (3), p.143-149

2004

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The thermodynamic characteristics of hydrogen peroxide in H2SO4-H2O solutions

Russian Journal of Physical Chemistry, 2006-12, Vol.80 (12), p.1895-1901

2006

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5-Hydroxypyrimidine deoxynucleoside triphosphates are more efficiently incorporated into DNA by exonuclease-free Klenow fragment than 8-oxopurine deoxynucleoside triphosphates

Nucleic acids research, 1994-09, Vol.22 (19), p.3930-3935

1994

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Broad-spectrum virus reduction in red cell concentrates using INACTINE™ PEN110 chemistry

Vox sanguinis, 2002-11, Vol.83 (4), p.313-323

2002

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The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates

2403 Comparison of effect of sorafenib (SOR) and CBL0137 (CBL), a novel drug targeting facilitates chromatin transcription (FACT) complex in woodchuck model of hepatitis B-related hepatocellular carcinoma (HCC)

A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications

New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase

FACT inhibitor CBL0137, administered in an optimized schedule, potentiates radiation therapy for glioblastoma by suppressing DNA damage repair

Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma

Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models

Synthesis of Carbazole Derivative PLX01107 and its Pharmacokinetics for Various Administration Routes in CD-1 Mice

Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT

422 CBL0137, a novel NFkB suppressor and p53 activator, is highly effective in pre-clinical models of neuroblastoma

Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer

Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas

Multiply damaged sites in DNA: interactions with Escherichia coli endonucleases III and VIII

Prevention of Colorectal Carcinogenesis by DNA-Binding Small-Molecule Curaxin CBL0137 Involves Suppression of Wnt Signaling

Enzymatic Processing of Uracil Glycol, a Major Oxidative Product of DNA Cytosine

Major oxidative products of cytosine, 5-hydroxycytosine and 5-hydroxyuracil, exhibit sequence context-dependent mispairing in vitro

Antitumor effect of the curaxin CBL0137 on the models of colon cancer

Genotoxicity of two new carbazole derivatives with antifungal activity

Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice

alpha.-Deoxyadenosine, a Major Anoxic Radiolysis Product of Adenine in DNA, Is a Substrate for Escherichia coli Endonuclease IV

Process for the preparation of pathogen-inactivated RBC concentrates by using PEN110 chemistry: preclinical studies

Inactivation of Gram-negative and Gram-positive bacteria in red cell concentrates using INACTINE PEN110 chemistry

The thermodynamic characteristics of hydrogen peroxide in H2SO4-H2O solutions

5-Hydroxypyrimidine deoxynucleoside triphosphates are more efficiently incorporated into DNA by exonuclease-free Klenow fragment than 8-oxopurine deoxynucleoside triphosphates

Broad-spectrum virus reduction in red cell concentrates using INACTINE™ PEN110 chemistry

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