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Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

Frontiers in pharmacology, 2022-09, Vol.13, p.977742

2022

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Editorial: Intersection of biophysical and structural approaches in vaccine design

Frontiers in molecular biosciences, 2023-02, Vol.10, p.1142656-1142656

2023

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Dynamics of Cleft Closure of the GluA2 Ligand-binding Domain in the Presence of Full and Partial Agonists Revealed by Hydrogen-Deuterium Exchange

The Journal of biological chemistry, 2013-09, Vol.288 (38), p.27658-27666

2013

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Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design

eLife, 2017-12, Vol.6

2017

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Homomeric interactions of the MPZ Ig domain and their relation to Charcot-Marie-Tooth disease

Brain (London, England : 1878), 2023-12, Vol.146 (12), p.5110-5123

2023

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7‑Phenoxy-Substituted 3,4-Dihydro‑2H‑1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

Journal of medicinal chemistry, 2018-01, Vol.61 (1), p.251-264

2018

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Noncompetitive antagonists induce cooperative AMPA receptor channel gating

The Journal of general physiology, 2019-02, Vol.151 (2), p.156-173

2019

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Probing the Allosteric Modulator Binding Site of GluR2 with Thiazide Derivatives

Biochemistry (Easton), 2009-09, Vol.48 (36), p.8594-8602

2009

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Novel Mycobacteria Antigen 85 Complex Binding Motif on Fibronectin

The Journal of biological chemistry, 2012-01, Vol.287 (3), p.1892-1902

2012

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Modulation of AMPA Receptor Gating by the Anticonvulsant Drug, Perampanel

ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.237-242

2019

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Elastin, a Novel Extracellular Matrix Protein Adhering to Mycobacterial Antigen 85 Complex

The Journal of biological chemistry, 2013-02, Vol.288 (6), p.3886-3896

2013

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Comparative screening of recombinant antigen thermostability for improved leptospirosis vaccine design

Biotechnology and bioengineering, 2019-02, Vol.116 (2), p.260-271

2019

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NMR Solution Structure of the Terminal Immunoglobulin-like Domain from the Leptospira Host-Interacting Outer Membrane Protein, LigB

Biochemistry (Easton), 2014-08, Vol.53 (32), p.5249-5260

2014

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Comparative genomic and phenomic analysis of Clostridium difficile and Clostridium sordellii, two related pathogens with differing host tissue preference

BMC genomics, 2015-06, Vol.16 (1), p.448-448, Article 448

2015

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Molecular Mechanism of Flop Selectivity and Subsite Recognition for an AMPA Receptor Allosteric Modulator: Structures of GluA2 and GluA3 in Complexes with PEPA

Biochemistry (Easton), 2010-04, Vol.49 (13), p.2843-2850

2010

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Effects of l-arabinose efflux on λ Red recombination-mediated gene knockout in multiple-antimicrobial-resistant Salmonella enterica serovar Choleraesuis

Archives of microbiology, 2018-03, Vol.200 (2), p.219-225

2018

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Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins

eNeuro, 2023-03, Vol.10 (3), p.ENEURO.0503-22.2023

2023

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The Perturbation of Tryptophan Fluorescence by Phenylalanine to Alanine Mutations Identifies the Hydrophobic Core in a Subset of Bacterial Ig-like Domains

Biochemistry (Easton), 2013-07, Vol.52 (27), p.4589-4591

2013

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Role of Stoichiometry in the Dimer-Stabilizing Effect of AMPA Receptor Allosteric Modulators

ACS chemical biology, 2014-01, Vol.9 (1), p.128-133

2014

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Homomeric interactions between IG domains of the MPZ (P0) myelin adhesion protein provide structural context for multiple disease mechanisms

Biophysical journal, 2024-02, Vol.123 (3), p.348a-348a

2024

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Electrostatic Interaction of a K+ Channel RCK Domain with Charged Membrane Surfaces

Biochemistry (Easton), 2005-01, Vol.44 (1), p.62-71

2005

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Sensing Allosteric Modulator Binding to AMPA Receptors at the Glutamate-Binding Site

Biophysical journal, 2016-02, Vol.110 (3), p.201a-201a

2016

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Disrupting the transmembrane domain interface between PMP22 and MPZ causes peripheral neuropathy

iScience, 2024-09, p.110989, Article 110989

2024

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AMPA Receptor Structure, Function, and Dynamics

Biophysical journal, 2015-01, Vol.108 (2), p.335a-336a

2015

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7-Phenoxy-Substituted 3,4-Dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

Journal of medicinal chemistry, 2018-01, Vol.61 (1), p.251-264

2018

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Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

Editorial: Intersection of biophysical and structural approaches in vaccine design

Dynamics of Cleft Closure of the GluA2 Ligand-binding Domain in the Presence of Full and Partial Agonists Revealed by Hydrogen-Deuterium Exchange

Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design

Homomeric interactions of the MPZ Ig domain and their relation to Charcot-Marie-Tooth disease

7‑Phenoxy-Substituted 3,4-Dihydro‑2H‑1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

Noncompetitive antagonists induce cooperative AMPA receptor channel gating

Probing the Allosteric Modulator Binding Site of GluR2 with Thiazide Derivatives

Novel Mycobacteria Antigen 85 Complex Binding Motif on Fibronectin

Modulation of AMPA Receptor Gating by the Anticonvulsant Drug, Perampanel

Elastin, a Novel Extracellular Matrix Protein Adhering to Mycobacterial Antigen 85 Complex

Comparative screening of recombinant antigen thermostability for improved leptospirosis vaccine design

NMR Solution Structure of the Terminal Immunoglobulin-like Domain from the Leptospira Host-Interacting Outer Membrane Protein, LigB

Comparative genomic and phenomic analysis of Clostridium difficile and Clostridium sordellii, two related pathogens with differing host tissue preference

Molecular Mechanism of Flop Selectivity and Subsite Recognition for an AMPA Receptor Allosteric Modulator: Structures of GluA2 and GluA3 in Complexes with PEPA

Effects of l-arabinose efflux on λ Red recombination-mediated gene knockout in multiple-antimicrobial-resistant Salmonella enterica serovar Choleraesuis

Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins

The Perturbation of Tryptophan Fluorescence by Phenylalanine to Alanine Mutations Identifies the Hydrophobic Core in a Subset of Bacterial Ig-like Domains

Role of Stoichiometry in the Dimer-Stabilizing Effect of AMPA Receptor Allosteric Modulators

Homomeric interactions between IG domains of the MPZ (P0) myelin adhesion protein provide structural context for multiple disease mechanisms

Electrostatic Interaction of a K+ Channel RCK Domain with Charged Membrane Surfaces

Sensing Allosteric Modulator Binding to AMPA Receptors at the Glutamate-Binding Site

Disrupting the transmembrane domain interface between PMP22 and MPZ causes peripheral neuropathy

AMPA Receptor Structure, Function, and Dynamics

7-Phenoxy-Substituted 3,4-Dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

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