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Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke

Current pharmaceutical design, 2012-09, Vol.18 (27), p.4215-4222

2012

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Stroke Treatment Academic Industry Roundtable X: Brain Cytoprotection Therapies in the Reperfusion Era

Stroke (1970), 2019-04, Vol.50 (4), p.1026-1031

2019

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Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation

Frontiers in neurology, 2021-03, Vol.12, p.593582-593582

2021

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3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase

Stroke (1970), 2020-07, Vol.51 (7), p.2236-2239

2020

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Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers

Current pharmaceutical design, 2013, Vol.19 (42), p.7479-7485

2013

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Top Priorities for Cerebroprotective Studies-A Paradigm Shift: Report From STAIR XI

Stroke (1970), 2021-09, Vol.52 (9), p.3063-3071

2021

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Final Results of the RHAPSODY Trial: A Multi‐Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A‐APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke

Annals of neurology, 2019-01, Vol.85 (1), p.125-136

2019

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Multifunctionalized Glycolurils

Organic letters, 1999-07, Vol.1 (1), p.39-42

1999

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The activated core approach to combinatorial chemistry: A selection of new core molecules

Tetrahedron, 1998-04, Vol.54 (16), p.4107-4124

1998

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Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection

Stroke (1970), 2016-12, Vol.47 (12), p.2979-2985

2016

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Randomized, controlled, dose escalation trial of a protease-activated receptor-1 agonist in acute ischemic stroke: Final Results of the RHAPSODY trial: A multi-center, Phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A-APC, a Recombinant Variant of Human Activated Protein C, in combination with tissue plasminogen activator, mechanical thrombectomy or both in moderate to severe acute ischemic stroke

Annals of neurology, 2019-01, Vol.85 (1), p.125-136

2019

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Synthesis and Screening of Small Molecule Libraries Active in Binding to DNA

Proceedings of the National Academy of Sciences - PNAS, 1997-10, Vol.94 (22), p.11833-11838

1997

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Stroke Treatment Academic Industry Roundtable Recommendations for Individual Data Pooling Analyses in Stroke

Stroke (1970), 2016-08, Vol.47 (8), p.2154-2159

2016

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2,5-Diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3)

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (12), p.3578-3581

2008

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A rapid method to identify exo-protease inhibitors

Bioorganic & medicinal chemistry letters, 1999-08, Vol.9 (16), p.2291-2296

1999

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The activated core approach to combinatorial chemistry

Pryor, Kent Edward

1999

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Deciphering chemical order/disorder and material properties at the single-atom level

Nature (London), 2017-02, Vol.542 (7639), p.75-79

2017

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Modeling Cassini UVIS Interplanetary Hydrogen Lyα Observations from 1999 to 2017

The Astrophysical journal, 2024-01, Vol.960 (2), p.117

2024

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Supporting Evidence for a Galactic Lyα Background from Cassini UVIS Data

The Astronomical journal, 2022-08, Vol.164 (2), p.46

2022

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SOHO SWAN Lyα Models Supporting LRO LAMP: 2008–2023

The planetary science journal, 2024-09, Vol.5 (9), p.210

2024

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American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Patient-Reported Outcomes in an Enhanced Recovery Pathway

Anesthesia and analgesia, 2018-06, Vol.126 (6), p.1874-1882

2018

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Microdeletions in the Y Chromosome of Infertile Men

The New England journal of medicine, 1997-02, Vol.336 (8), p.534-540

1997

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Defining regions of the Y-chromosome responsible for male infertility and identification of a fourth AZF region (AZFd) by Y-chromosome microdeletion detection

Molecular reproduction and development, 1999-05, Vol.53 (1), p.27-41

1999

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Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke

Stroke Treatment Academic Industry Roundtable X: Brain Cytoprotection Therapies in the Reperfusion Era

Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation

3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase

Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers

Top Priorities for Cerebroprotective Studies-A Paradigm Shift: Report From STAIR XI

Multifunctionalized Glycolurils

The activated core approach to combinatorial chemistry: A selection of new core molecules

Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection

Synthesis and Screening of Small Molecule Libraries Active in Binding to DNA

Stroke Treatment Academic Industry Roundtable Recommendations for Individual Data Pooling Analyses in Stroke

2,5-Diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3)

A rapid method to identify exo-protease inhibitors

The activated core approach to combinatorial chemistry

Deciphering chemical order/disorder and material properties at the single-atom level

Modeling Cassini UVIS Interplanetary Hydrogen Lyα Observations from 1999 to 2017

American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Nutrition Screening and Therapy Within a Surgical Enhanced Recovery Pathway

Supporting Evidence for a Galactic Lyα Background from Cassini UVIS Data

SOHO SWAN Lyα Models Supporting LRO LAMP: 2008–2023

American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Patient-Reported Outcomes in an Enhanced Recovery Pathway

American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Postoperative Gastrointestinal Dysfunction Within an Enhanced Recovery Pathway for Elective Colorectal Surgery

Microdeletions in the Y Chromosome of Infertile Men

Defining regions of the Y-chromosome responsible for male infertility and identification of a fourth AZF region (AZFd) by Y-chromosome microdeletion detection

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