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Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid

Cancer chemotherapy and pharmacology, 1997, Vol.39 (6), p.541-546

1997

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Effect of Nitroreduction on the Alkylating Reactivity and Cytotoxicity of the 2,4-Dinitrobenzamide-5-aziridine CB 1954 and the Corresponding Nitrogen Mustard SN 23862: Distinct Mechanisms of Bioreductive Activation

Chemical research in toxicology, 2003-04, Vol.16 (4), p.469-478

2003

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Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicellular layers of tumor cells

The Journal of pharmacology and experimental therapeutics, 2001-06, Vol.297 (3), p.1088

2001

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Bis(dialkyl)dithiocarbamato cobalt(III) complexes of bidentate nitrogen mustards: synthesis, reduction chemistry and biological evaluation as hypoxia-selective cytotoxins

Anti-cancer drug design, 1998-03, Vol.13 (2), p.81

1998

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Changes in inositol-1, 4, 5-trisphosphate binding to hepatic plasma membranes caused by temperature, N-ethylmaleimide and menadione

Biochemical pharmacology, 1990-11, Vol.40 (9), p.1947-1952

1990

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Synthesis and Structure−Activity Relationships for 2,4-Dinitrobenzamide-5-mustards as Prodrugs for the Escherichia coli nfsB Nitroreductase in Gene Therapy

Journal of medicinal chemistry, 2007-03, Vol.50 (6), p.1197-1212

2007

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Multicellular resistance to tirapazamine is due to restricted extravascular transport: A pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures

Cancer research (Chicago, Ill.), 2003-09, Vol.63 (18), p.5970-5977

2003

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Structure−Activity Relationships of 1,2,4-Benzotriazine 1,4-Dioxides as Hypoxia-Selective Analogues of Tirapazamine

Journal of medicinal chemistry, 2003-01, Vol.46 (1), p.169-182

2003

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Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

Cancer chemotherapy and pharmacology, 2003, Vol.51 (1), p.43-52

2003

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Extravascular Transport of Drugs in Tumor Tissue: Effect of Lipophilicity on Diffusion of Tirapazamine Analogues in Multicellular Layer Cultures

Journal of medicinal chemistry, 2005-02, Vol.48 (4), p.1079-1087

2005

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DNA-Targeted 1,2,4-Benzotriazine 1,4-Dioxides: Potent Analogues of the Hypoxia-Selective Cytotoxin Tirapazamine

Journal of medicinal chemistry, 2004-01, Vol.47 (2), p.475-488

2004

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Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317

Cancer research (Chicago, Ill.), 2004-01, Vol.64 (2), p.736-742

2004

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Oxygen Dependence of the Metabolic Activation and Cytotoxicity of Tirapazamine: Implications for Extravascular Transport and Activity in Tumors

Radiation research, 2004-06, Vol.161 (6), p.656-666

2004

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Inactivation of Mitochondrial Metabolism by Hyperoxia-Induced Oxidative Stress

Annals of the New York Academy of Sciences, 1992-11, Vol.663 (1), p.453-455

1992

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Interplay between Vitamin E, Glutathione and Dihydrolipoic Acid in Protection against Lipid Peroxidation

Fett (Weinheim), 1991, Vol.93 (6), p.216-221

1991

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Menadione inhibits the alpha 1-adrenergic receptor-mediated increase in cytosolic free calcium concentration in hepatocytes by inhibiting inositol 1,4,5-trisphosphate-dependent release of calcium from intracellular stores

Biochemical pharmacology, 1991-10, Vol.42 (10), p.1977-1986

1991

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Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting

Biochemical pharmacology, 2003-06, Vol.65 (11), p.1807-1815

2003

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The effects of radical stress and N-ethylmaleimide on rat hepatic alpha 1-adrenergic receptors

Toxicology letters, 1989-01, Vol.45 (1), p.73-82

1989

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Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5

Cancer chemotherapy and pharmacology, 2000, Vol.46 (5), p.365

2000

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Hypoxia-activated prodrugs as antitumour agents: strategies for maximizing tumour cell killing

Clinical and experimental pharmacology & physiology, 1995-11, Vol.22 (11), p.881-885

1995

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Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5-[N, N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide (SN 23862) and the corresponding aziridine (CB 1954) in KHT tumour-bearing mice

Cancer chemotherapy and pharmacology, 2000-11, Vol.46 (5), p.365-374

2000

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Menadione inhibits the α1-adrenergic receptor-mediated incrase in cytosolic free calcium concentration in hepatocytes by inhibiting inositol 1,4,5-trisphosphate-dependent release of calcium from intracellular stores

Biochemical pharmacology, 1991, Vol.42 (10), p.1977-1986

1991

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Targeting Tumor Hypoxia with Prodrugs: Challenges and Opportunities

AACR education book, 2008-04, Vol.2008 (1), p.293-310

2008

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The effects of radical stress and N-ethylmaleimide on rat hepatic α1-adrenergic receptors

Toxicology letters, 1989, Vol.45 (1), p.73-82

1989

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Cytosolic 5′-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis

Annals of the rheumatic diseases, 2017-05, Vol.76 (5), p.862-868

2017

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Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid

Effect of Nitroreduction on the Alkylating Reactivity and Cytotoxicity of the 2,4-Dinitrobenzamide-5-aziridine CB 1954 and the Corresponding Nitrogen Mustard SN 23862: Distinct Mechanisms of Bioreductive Activation

Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicellular layers of tumor cells

Bis(dialkyl)dithiocarbamato cobalt(III) complexes of bidentate nitrogen mustards: synthesis, reduction chemistry and biological evaluation as hypoxia-selective cytotoxins

Changes in inositol-1, 4, 5-trisphosphate binding to hepatic plasma membranes caused by temperature, N-ethylmaleimide and menadione

Synthesis and Structure−Activity Relationships for 2,4-Dinitrobenzamide-5-mustards as Prodrugs for the Escherichia coli nfsB Nitroreductase in Gene Therapy

Multicellular resistance to tirapazamine is due to restricted extravascular transport: A pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures

Structure−Activity Relationships of 1,2,4-Benzotriazine 1,4-Dioxides as Hypoxia-Selective Analogues of Tirapazamine

Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

Extravascular Transport of Drugs in Tumor Tissue: Effect of Lipophilicity on Diffusion of Tirapazamine Analogues in Multicellular Layer Cultures

DNA-Targeted 1,2,4-Benzotriazine 1,4-Dioxides: Potent Analogues of the Hypoxia-Selective Cytotoxin Tirapazamine

Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317

Oxygen Dependence of the Metabolic Activation and Cytotoxicity of Tirapazamine: Implications for Extravascular Transport and Activity in Tumors

Inactivation of Mitochondrial Metabolism by Hyperoxia-Induced Oxidative Stress

Interplay between Vitamin E, Glutathione and Dihydrolipoic Acid in Protection against Lipid Peroxidation

Menadione inhibits the alpha 1-adrenergic receptor-mediated increase in cytosolic free calcium concentration in hepatocytes by inhibiting inositol 1,4,5-trisphosphate-dependent release of calcium from intracellular stores

Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting

The effects of radical stress and N-ethylmaleimide on rat hepatic alpha 1-adrenergic receptors

Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5

Hypoxia-activated prodrugs as antitumour agents: strategies for maximizing tumour cell killing

Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5-[N, N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide (SN 23862) and the corresponding aziridine (CB 1954) in KHT tumour-bearing mice

Menadione inhibits the α1-adrenergic receptor-mediated incrase in cytosolic free calcium concentration in hepatocytes by inhibiting inositol 1,4,5-trisphosphate-dependent release of calcium from intracellular stores

Targeting Tumor Hypoxia with Prodrugs: Challenges and Opportunities

The effects of radical stress and N-ethylmaleimide on rat hepatic α1-adrenergic receptors

Cytosolic 5′-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis

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