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Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton

Trends in cell biology, 2018-10, Vol.28 (10), p.776-792

2018

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Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics

PloS one, 2016-08, Vol.11 (8), p.e0160890-e0160890

2016

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Fragility curves for different classes of existing RC buildings under ground differential settlements

Engineering structures, 2022-04, Vol.257, p.114077, Article 114077

2022

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Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

Science (American Association for the Advancement of Science), 2013-02, Vol.339 (6119), p.587-590

2013

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Comprehensive Analysis of Binding Sites in Tubulin

Angewandte Chemie International Edition, 2021-06, Vol.60 (24), p.13331-13342

International ed. in English, 2021

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Structure-based discovery and rational design of microtubule-targeting agents

Current opinion in structural biology, 2024-08, Vol.87, p.102845, Article 102845

2024

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new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (38), p.13817-13821

2014

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Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons

Nature communications, 2017-09, Vol.8 (1), p.542-11, Article 542

2017

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The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

Journal of molecular biology, 2014-04, Vol.426 (8), p.1848-1860

2014

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Computational Approaches to the Rational Design of Tubulin-Targeting Agents

Biomolecules (Basel, Switzerland), 2023-02, Vol.13 (2), p.285

2023

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Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (9)

2021

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Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

Molecular cell, 2017-10, Vol.68 (1), p.210-223.e6

2017

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Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A

Angewandte Chemie (International ed.), 2014-02, Vol.53 (6), p.1621-1625

2014

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Structural basis of tubulin tyrosination by tubulin tyrosine ligase

The Journal of cell biology, 2013-02, Vol.200 (3), p.259-270

2013

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Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes

Current biology, 2016-07, Vol.26 (13), p.1713-1721

2016

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ADAfinder Tool Applied to EGMS Data for the Structural Health Monitoring of Urban Settlements

Remote sensing (Basel, Switzerland), 2023-01, Vol.15 (2), p.324

2023

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Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

Nature communications, 2017-03, Vol.8 (1), p.14683-14683, Article 14683

2017

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Bridging the maytansine and vinca sites: Cryptophycins target β-tubulin’s T5-loop

The Journal of biological chemistry, 2024-06, Vol.300 (6), p.107363, Article 107363

2024

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Effects of Defects on Masonry Confinement with Inorganic Matrix Composites

Materials, 2023-06, Vol.16 (13), p.4737

2023

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Structural model for differential cap maturation at growing microtubule ends

eLife, 2020-03, Vol.9

2020

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Effect of buoyancy loads on the tsunami fragility of existing reinforced concrete frames including consideration of blow-out slabs

Scientific reports, 2023-06, Vol.13 (1), p.9015-9015, Article 9015

2023

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Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents

European journal of medicinal chemistry, 2022-11, Vol.241, p.114614-114614, Article 114614

2022

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Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas

European journal of medicinal chemistry, 2022-12, Vol.243, p.114744-114744, Article 114744

2022

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Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action

Angewandte Chemie International Edition, 2022-06, Vol.61 (25), p.e202204052-n/a

International ed. in English, 2022

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Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.1031-1044

2018

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Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton

Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics

Fragility curves for different classes of existing RC buildings under ground differential settlements

Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

Comprehensive Analysis of Binding Sites in Tubulin

Structure-based discovery and rational design of microtubule-targeting agents

new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons

The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

Computational Approaches to the Rational Design of Tubulin-Targeting Agents

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent

Structural Basis of Microtubule Stabilization by Laulimalide and Peloruside A

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes

ADAfinder Tool Applied to EGMS Data for the Structural Health Monitoring of Urban Settlements

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

Bridging the maytansine and vinca sites: Cryptophycins target β-tubulin’s T5-loop

Effects of Defects on Masonry Confinement with Inorganic Matrix Composites

Structural model for differential cap maturation at growing microtubule ends

Effect of buoyancy loads on the tsunami fragility of existing reinforced concrete frames including consideration of blow-out slabs

Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents

Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas

Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action

Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure

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