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Bardoxolone methyl analog attenuates proteinuria‐induced tubular damage by modulating mitochondrial function

The FASEB journal, 2019-11, Vol.33 (11), p.12253-12263

2019

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Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis

Radiation research, 2014-05, Vol.181 (5), p.512

2014

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Omaveloxolone and TX63682 are hepatoprotective in the STAM mouse model of nonalcoholic steatohepatitis

Journal of biochemical and molecular toxicology, 2020-09, Vol.34 (9), p.e22526-n/a

2020

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Human aqueous humor concentrations of besifloxacin, moxifloxacin, and gatifloxacin after topical ocular application

Journal of cataract and refractive surgery, 2011-06, Vol.37 (6), p.1082-1089

2011

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A rapid and sensitive LC/MS/MS assay for the quantitation of brimonidine in ocular fluids and tissues

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009-01, Vol.877 (3), p.107-114

2009

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Quantitative determination of besifloxacin, a novel fluoroquinolone antimicrobial agent, in human tears by liquid chromatography–tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-05, Vol.867 (1), p.105-110

2008

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Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Drug design, development and therapy, 2019-01, Vol.13, p.1259-1270

2019

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Concentrations of besifloxacin, gatifloxacin, and moxifloxacin in human conjunctiva after topical ocular administration

Clinical ophthalmology (Auckland, N.Z.), 2010-01, Vol.4 (default), p.331-341

2010

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Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin

Archives of Dermatological Research, 2014-07, Vol.306 (5), p.447-454

2014

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Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey

Drug metabolism and disposition, 2004-02, Vol.32 (2), p.172-177

2004

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Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

OncoTargets and therapy, 2017-01, Vol.10, p.4239-4250

2017

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A single dose of monoclonal anti-phencyclidine IgG offers long-term reductions in phencyclidine behavioral effects in rats

The Journal of pharmacology and experimental therapeutics, 2002-07, Vol.302 (1), p.119-126

2002

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Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits

Journal of ocular pharmacology and therapeutics, 2010-10, Vol.26 (5), p.449-458

2010

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Ocular pharmacokinetics of mapracorat, a novel, selective glucocorticoid receptor agonist, in rabbits and monkeys

Drug metabolism and disposition, 2011-07, Vol.39 (7), p.1181-1187

2011

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Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

BMC dermatology, 2015-07, Vol.15 (1), p.10, Article 10

2015

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Development of an in vivo preclinical screen model to estimate absorption and bioavailability of xenobiotics

Drug metabolism and disposition, 2001-01, Vol.29 (1), p.82

2001

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Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans

Journal of ocular pharmacology and therapeutics, 2009-08, Vol.25 (4), p.335-344

2009

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Cassette Dosing Pharmacokinetic Studies for Evaluation of Ophthalmic Drugs for Posterior Ocular Diseases

Journal of pharmaceutical sciences, 2008-08, Vol.97 (8), p.3411-3421

2008

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The use of the African green monkey as a preclinical model for ocular pharmacokinetic studies

Journal of ocular pharmacology and therapeutics, 2012-06, Vol.28 (3), p.290-298

2012

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Anti-phencyclidine monoclonal antibodies provide long-term reductions in brain phencyclidine concentrations during chronic phencyclidine administration in rats

The Journal of pharmacology and experimental therapeutics, 2000-03, Vol.292 (3), p.831

2000

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RTA 1701 is an oral RORγt inhibitor that suppresses the IL-17A response in non-human primates

The Journal of immunology (1950), 2018-05, Vol.200 (1_Supplement), p.175-175.22

2018

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Nonclinical safety and pharmacokinetics of intravitreally administered human-derived plasmin in rabbits and minipigs

Journal of ocular pharmacology and therapeutics, 2008-06, Vol.24 (3), p.320-332

2008

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The effect of rate of drug administration on the extent and time course of phencyclidine distribution in rat brain, testis, and serum

Drug metabolism and disposition, 2000-07, Vol.28 (7), p.742

2000

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Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Drug design, development and therapy, 2019-04, p.1259

2019

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Pharmacokinetic mechanisms for obtaining high renal coelimination of phencyclidine and a monoclonal antiphencyclidine antigen-binding fragment of immunoglobulin G in the rat

The Journal of pharmacology and experimental therapeutics, 1998-11, Vol.287 (2), p.616

1998

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Bardoxolone methyl analog attenuates proteinuria‐induced tubular damage by modulating mitochondrial function

Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis

Omaveloxolone and TX63682 are hepatoprotective in the STAM mouse model of nonalcoholic steatohepatitis

Human aqueous humor concentrations of besifloxacin, moxifloxacin, and gatifloxacin after topical ocular application

A rapid and sensitive LC/MS/MS assay for the quantitation of brimonidine in ocular fluids and tissues

Quantitative determination of besifloxacin, a novel fluoroquinolone antimicrobial agent, in human tears by liquid chromatography–tandem mass spectrometry

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Concentrations of besifloxacin, gatifloxacin, and moxifloxacin in human conjunctiva after topical ocular administration

Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin

Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey

Safety, pharmacokinetics, and pharmacodynamics of oral omaveloxolone (RTA 408), a synthetic triterpenoid, in a first-in-human trial of patients with advanced solid tumors

A single dose of monoclonal anti-phencyclidine IgG offers long-term reductions in phencyclidine behavioral effects in rats

Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits

Ocular pharmacokinetics of mapracorat, a novel, selective glucocorticoid receptor agonist, in rabbits and monkeys

Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers

Development of an in vivo preclinical screen model to estimate absorption and bioavailability of xenobiotics

Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans

Cassette Dosing Pharmacokinetic Studies for Evaluation of Ophthalmic Drugs for Posterior Ocular Diseases

The use of the African green monkey as a preclinical model for ocular pharmacokinetic studies

Anti-phencyclidine monoclonal antibodies provide long-term reductions in brain phencyclidine concentrations during chronic phencyclidine administration in rats

RTA 1701 is an oral RORγt inhibitor that suppresses the IL-17A response in non-human primates

Nonclinical safety and pharmacokinetics of intravitreally administered human-derived plasmin in rabbits and minipigs

The effect of rate of drug administration on the extent and time course of phencyclidine distribution in rat brain, testis, and serum

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

Pharmacokinetic mechanisms for obtaining high renal coelimination of phencyclidine and a monoclonal antiphencyclidine antigen-binding fragment of immunoglobulin G in the rat

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