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A Novel Prodrug Approach for Central Nervous System-Selective Estrogen Therapy

Molecules (Basel, Switzerland), 2019-11, Vol.24 (22), p.4197

2019

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The impact of 17β-estradiol on the estrogen-deficient female brain: from mechanisms to therapy with hot flushes as target symptoms

Frontiers in endocrinology (Lausanne), 2024-01, Vol.14, p.1310432-1310432

2024

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Proteomics-Based Identification of Retinal Protein Networks Impacted by Elevated Intraocular Pressure in the Hypertonic Saline Injection Model of Experimental Glaucoma

International journal of molecular sciences, 2023-08, Vol.24 (16), p.12592

2023

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[β-Glu2]TRH Is a Functional Antagonist of Thyrotropin-Releasing Hormone (TRH) in the Rodent Brain

International journal of molecular sciences, 2021-06, Vol.22 (12), p.6230

2021

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Application of Screening Experimental Designs to Assess Chromatographic Isotope Effect upon Isotope-Coded Derivatization for Quantitative Liquid Chromatography–Mass Spectrometry

Analytical chemistry (Washington), 2014-07, Vol.86 (14), p.7033-7040

2014

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Comparative Proteomics Analysis Reveals Unique Early Signaling Response of Saccharomyces cerevisiae to Oxidants with Different Mechanism of Action

International journal of molecular sciences, 2020-12, Vol.22 (1), p.167

2020

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The Antagonist pGlu-βGlu-Pro-NH2 Binds to an Allosteric Site of the Thyrotropin-Releasing Hormone Receptor

Molecules (Basel, Switzerland), 2021-09, Vol.26 (17), p.5397

2021

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Proteomics Complementation of the Rat Uterotrophic Assay for Estrogenic Endocrine Disruptors: A Roadmap of Advancing High Resolution Mass Spectrometry-Based Shotgun Survey to Targeted Biomarker Quantifications

International journal of molecular sciences, 2021-02, Vol.22 (4), p.1686

2021

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Cholinergic Neurons in the Basal Forebrain Promote Wakefulness by Actions on Neighboring Non-Cholinergic Neurons: An Opto-Dialysis Study

The Journal of neuroscience, 2016-02, Vol.36 (6), p.2057-2067

2016

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An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

Hormones and behavior, 2018-02, Vol.98, p.16-21

2018

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Effect of estradiol replacement on hippocampal concentrations of estrogens in aged rhesus macaques maintained on an obesogenic diet

Biochemistry and biophysics reports, 2023-09, Vol.35, p.101548-101548, Article 101548

2023

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Selective Chemoprecipitation and Subsequent Release of Tagged Species for the Analysis of Nitropeptides by Liquid Chromatography–Tandem Mass Spectrometry

Molecular & cellular proteomics, 2011-08, Vol.10 (8), p.M110.002923-M110.002923, Article M110.002923

2011

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The Prodrug DHED Delivers 17β-Estradiol into the Retina for Protection of Retinal Ganglion Cells and Preservation of Visual Function in an Animal Model of Glaucoma

Cells (Basel, Switzerland), 2024-06, Vol.13 (13), p.1126

2024

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17β-Estradiol Delivered in Eye Drops: Evidence of Impact on Protein Networks and Associated Biological Processes in the Rat Retina through Quantitative Proteomics

Pharmaceutics, 2020-01, Vol.12 (2), p.101

2020

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Proteomics-Based Retinal Target Engagement Analysis and Retina-Targeted Delivery of 17β-Estradiol by the DHED Prodrug for Ocular Neurotherapy in Males

Pharmaceutics, 2021-09, Vol.13 (9), p.1392

2021

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Brain-Selective Estrogen Therapy Prevents Androgen Deprivation-Associated Hot Flushes in a Rat Model

Pharmaceuticals (Basel, Switzerland), 2020-06, Vol.13 (6), p.119

2020

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Factors That Contribute to the Misidentification of Tyrosine Nitration by Shotgun Proteomics

Molecular & cellular proteomics, 2008-12, Vol.7 (12), p.2442-2451

2008

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Targeted Delivery of Small Interfering RNA Using Reconstituted High-Density Lipoprotein Nanoparticles

Neoplasia (New York, N.Y.), 2011-04, Vol.13 (4), p.309-IN8

2011

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Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling

Biochemistry (Easton), 2010-07, Vol.49 (29), p.6263-6275

2010

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Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds

Pharmacology & therapeutics (Oxford), 2007-04, Vol.114 (1), p.1-12

2007

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Mitochondrial Localization of Estrogen Receptor β

Proceedings of the National Academy of Sciences - PNAS, 2004-03, Vol.101 (12), p.4130-4135

2004

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Direct Analysis in Real Time (DART) of an Organothiophosphate at Ultrahigh Resolution by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry

International journal of molecular sciences, 2016-01, Vol.17 (1), p.116-116

2016

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Retina-Targeted Delivery of 17β-Estradiol by the Topically Applied DHED Prodrug

Pharmaceutics, 2020-05, Vol.12 (5), p.456

2020

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Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents

Molecules, 2009-02, Vol.14 (2), p.633-654

2009

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Quinol-Based Cyclic Antioxidant Mechanism in Estrogen Neuroprotection

Proceedings of the National Academy of Sciences - PNAS, 2003-09, Vol.100 (20), p.11741-11746

2003

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A Novel Prodrug Approach for Central Nervous System-Selective Estrogen Therapy

The impact of 17β-estradiol on the estrogen-deficient female brain: from mechanisms to therapy with hot flushes as target symptoms

Proteomics-Based Identification of Retinal Protein Networks Impacted by Elevated Intraocular Pressure in the Hypertonic Saline Injection Model of Experimental Glaucoma

[β-Glu2]TRH Is a Functional Antagonist of Thyrotropin-Releasing Hormone (TRH) in the Rodent Brain

Application of Screening Experimental Designs to Assess Chromatographic Isotope Effect upon Isotope-Coded Derivatization for Quantitative Liquid Chromatography–Mass Spectrometry

Comparative Proteomics Analysis Reveals Unique Early Signaling Response of Saccharomyces cerevisiae to Oxidants with Different Mechanism of Action

The Antagonist pGlu-βGlu-Pro-NH2 Binds to an Allosteric Site of the Thyrotropin-Releasing Hormone Receptor

Proteomics Complementation of the Rat Uterotrophic Assay for Estrogenic Endocrine Disruptors: A Roadmap of Advancing High Resolution Mass Spectrometry-Based Shotgun Survey to Targeted Biomarker Quantifications

Cholinergic Neurons in the Basal Forebrain Promote Wakefulness by Actions on Neighboring Non-Cholinergic Neurons: An Opto-Dialysis Study

An exploratory investigation of brain-selective estrogen treatment in males using a mouse model of Alzheimer's disease

Effect of estradiol replacement on hippocampal concentrations of estrogens in aged rhesus macaques maintained on an obesogenic diet

Selective Chemoprecipitation and Subsequent Release of Tagged Species for the Analysis of Nitropeptides by Liquid Chromatography–Tandem Mass Spectrometry

The Prodrug DHED Delivers 17β-Estradiol into the Retina for Protection of Retinal Ganglion Cells and Preservation of Visual Function in an Animal Model of Glaucoma

17β-Estradiol Delivered in Eye Drops: Evidence of Impact on Protein Networks and Associated Biological Processes in the Rat Retina through Quantitative Proteomics

Proteomics-Based Retinal Target Engagement Analysis and Retina-Targeted Delivery of 17β-Estradiol by the DHED Prodrug for Ocular Neurotherapy in Males

Brain-Selective Estrogen Therapy Prevents Androgen Deprivation-Associated Hot Flushes in a Rat Model

Factors That Contribute to the Misidentification of Tyrosine Nitration by Shotgun Proteomics

Targeted Delivery of Small Interfering RNA Using Reconstituted High-Density Lipoprotein Nanoparticles

Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling

Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds

Mitochondrial Localization of Estrogen Receptor β

Direct Analysis in Real Time (DART) of an Organothiophosphate at Ultrahigh Resolution by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry

Retina-Targeted Delivery of 17β-Estradiol by the Topically Applied DHED Prodrug

Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents

Quinol-Based Cyclic Antioxidant Mechanism in Estrogen Neuroprotection

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